Overview of studies of treatments for hand eczema-the EDEN hand eczema survey

Coevorden, A. Marco van; Coenraads, P.J.; Svensson, Åke; Bavinck, Jan Nico Bouwes; Diepgen, Thomas L.; Naldi, Luigi; Elsner, Peter; Williams, Hywel C

doi:10.1111/j.1365-2133.2004.06040.x

Cited by 82 publications

(55 citation statements)

References 13 publications

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“…19 Current treatment strategies are largely based on clinical experience and may differ from country to country. 7,8,20 Few therapies have been evaluated in randomized, controlled trials, 21 and the trials that have been conducted typically have not distinguished types of eczema. Figure 3 shows an algorithm for the management of hand eczema.…”

Section: Hand Eczemamentioning

confidence: 99%

Hand Eczema

2012

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Section: Hand Eczemamentioning

confidence: 99%

Hand Eczema

2012

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“…sults of randomized trials, all of them were performed in the eighties (Table 1). According to current standards they hardly fulfill criteria for evidence-based medicine [3,20,30]. They included low numbers of patients and follow-up was only 5 weeks to 6 months (median 4 months).…”

Section: Discussionmentioning

confidence: 99%

“…Severity-scores for symptoms were different and simplified encompassing several symptoms. Due to the absence of accepted severity-scores in both eczema and psoriasis [5,20,30,31] a comparison of trials is difficult. Regarding RT single doses of 0.9 Gy -4 Gy and total doses of 2.7 Gy -24 Gy were used in these trials.…”

Section: Discussionmentioning

confidence: 99%

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Long-term Results of Radiotherapy in Patients with Chronic Palmo-plantar Eczema or Psoriasis

Sumila¹,

Notter²,

Itin

et al. 2008

Strahlenther Onkol

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Background and Purpose: Radiotherapy (RT) is well accepted for therapy-refractory palmo-plantar eczema or psoriasis, despite of lacking evidence regarding beneficial long term effects. Furthermore, the optimal irradiation dose is unknown. We evaluated the outcome of RT with two different RT single/total dose (SD/TD) treatment policies. Patients and Methods: 28 consecutive patients with therapy-refractory eczema (n = 22) or psoriasis (n = 6) of palms and/or soles were irradiated twice a week either with a D max SD of 1 Gy (6/98-5/03; median TD: 12 Gy) or 0.5 Gy (6/03-7/04; median TD: 5 Gy). Median age was 52 years (27-71), median follow-up 20 months (4-76). Totally 88 regions were treated, 49 with 1 Gy, 39 with 0.5 Gy SD. Eight different symptoms were scored from 0 (absent) -3 (severe), giving a possible sum score of 0-24. Patients' rating of RT result was also documented (worse/stable/better/complete remission). Results: The sum score was 15 (6-23) before RT, 2 (0-16) at the end of RT, and 1 (0-21) at last follow-up, respectively. The improvement was highly significant in both treatment regimens. Better or complete remission by the patients were reported in 44 and 39 (= 83 out of 88) localisations, that was often stable during the follow-up. 5 (6%) regions in 3 (11%) patients didn't benefit from RT. Conclusion: RT reveals excellent results in palmo-plantar eczema or psoriasis. We recommend a SD of 0.5 Gy twice a week up to a TD of 4-5 Gy.

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“…Gdy terapia miejscowa wydaje się niewystarczająca, kolejną opcją leczniczą jest włączenie systemowych preparatów glikokortykosteroidowych. W piśmiennictwie relacjonowane są także próby leczenia azatiopryną, cyklosporyną, mykofenolanem mofetylu czy acytretyną [13][14][15][16]. W każdym przypadku warto jednak indywidualnie rozważyć rachunek zysków i strat wynikających ze skutków ubocznych danej terapii ogólnej.…”

Section: Introductionunclassified

Alitretinoin in treatment of chronic hand eczema – mechanism of action

Matejko¹,

Krêcisz²

2016

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Przegląd Dermatologiczny 2016/5 StreSzczeniePrzewlekły wyprysk kontaktowy rąk to powszechne schorzenie, któ-re wywiera negatywny wpływ na funkcjonowanie i psychikę chorego. Stosowanie dostępnych, tradycyjnych metod leczniczych, takich jak miejscowe glikokortykosteroidy, inhibitory kalcyneuryny, fototerapia, leki immunosupresyjne, jest często niesatysfakcjonujące ze względu na brak zadowalającego rezultatu lub skutki uboczne. Alitretynoina (kwas 9-cis-retinowy) to aktywna substancja z grupy retinoidów zarejestrowana do ogólnoustrojowej terapii przewlekłego wyprysku kontaktowego rąk opornego na leczenie miejscowe. Jest agonistą zarówno receptorów RAR (receptory kwasu retinowego), jak i RXR (receptory X retinoidów) oraz pełni funkcję przeciwzapalną i immunomodulującą, ingerując w reakcję zapalną na różnych jej odcinkach. Dobra tolerancja leku oraz potwierdzona w badaniach klinicznych skuteczność terapeutyczna wskazują, że alitretynoina może być korzystną alternatywą leczniczą dla pacjentów z przewlekłym wypryskiem rąk opornym na inne formy terapii. AbStrActHand eczema is a common skin disorder with significant functional and economic impacts. Conventional therapy options, such as topical corticosteroids, calcineurin inhibitors, phototherapy and systemic immunosuppressants, often give unsatisfactory results, due to lack of efficacy or predominant adverse effects. Alitretinoin (9-cis-retinoic acid) is an active substance from the group of retinoids and is licensed as a systemic drug for chronic and severe hand eczema refractory to topical treatment. It binds with high affinity to both retinoic acid receptor (RAR) and retinoid X receptor (RXR) receptors and presents anti-inflammatory and immunomodulatory activity. Due to its good tolerance and high efficacy, demonstrated in several large clinical studies, alitretinoin may be an option for patients with severe chronic hand eczema refractory to other treatment. kontaktowe zapalenie skóry, wyprysk rąk oporny na leczenie, kwas 9-cis-retinowy, alitretynoina.

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Overview of studies of treatments for hand eczema-the EDEN hand eczema survey

Cited by 82 publications

References 13 publications

Hand Eczema

Hand Eczema

Long-term Results of Radiotherapy in Patients with Chronic Palmo-plantar Eczema or Psoriasis

Alitretinoin in treatment of chronic hand eczema – mechanism of action

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