Key words: B-type natriuretic peptide, cardiac pacing, left atrial volume index.Słowa kluczowe: peptyd natriuretyczny typu B, stymulacja serca, indeks objętości lewego przedsionka. AbstractIntroduction: The present study was undertaken to evaluate the practical value of BNP measurements and echocardiographic left ventricular volume index in patients with permanent pacemakers because there are no such reports in the literature. Aim of the research: The aim of the study was to reveal multiple correlations between BNP levels and selected echocardiographic parameters of the left atrium in patients with permanent pacemakers. In the literature there are reports on the significance of BNP values and left atrial size in patients with permanent pacemakers. The results of the present study appear to be of value in the outpatient assessment of these patients. Material and methods:We analysed a group of 117 patients with permanent pacemakers (AAI/R 21 patients, DDD/R 59 patients, VVI/R 37 patients) and 48 healthy volunteers serving as the control group. BNP measurements were performed on venous blood samples using Triage meters. The Simpson method and the ellipse method were used to assess the left atrium on echocardiography. Results: There was a significant correlation between BNP and maximum left atrial volume, minimum left atrial volume, and left atrial volume index in patients with AAI/R, DDD/R, and VVI/R pacemakers at 3 and 6 months after the implantation. Conclusions: In patients after implantation of permanent pacemakers there are correlations between BNP values and echocardiographic left atrial parameters, especially in patients with DDD/R pacemakers. Left atrial function improves in patients with DDD/R pacemakers. Pacemaker check-up should be extended to include BNP measurements and echocardiographic assessment of the left atrium.
Przegląd Dermatologiczny 2016/5 StreSzczeniePrzewlekły wyprysk kontaktowy rąk to powszechne schorzenie, któ-re wywiera negatywny wpływ na funkcjonowanie i psychikę chorego. Stosowanie dostępnych, tradycyjnych metod leczniczych, takich jak miejscowe glikokortykosteroidy, inhibitory kalcyneuryny, fototerapia, leki immunosupresyjne, jest często niesatysfakcjonujące ze względu na brak zadowalającego rezultatu lub skutki uboczne. Alitretynoina (kwas 9-cis-retinowy) to aktywna substancja z grupy retinoidów zarejestrowana do ogólnoustrojowej terapii przewlekłego wyprysku kontaktowego rąk opornego na leczenie miejscowe. Jest agonistą zarówno receptorów RAR (receptory kwasu retinowego), jak i RXR (receptory X retinoidów) oraz pełni funkcję przeciwzapalną i immunomodulującą, ingerując w reakcję zapalną na różnych jej odcinkach. Dobra tolerancja leku oraz potwierdzona w badaniach klinicznych skuteczność terapeutyczna wskazują, że alitretynoina może być korzystną alternatywą leczniczą dla pacjentów z przewlekłym wypryskiem rąk opornym na inne formy terapii. AbStrActHand eczema is a common skin disorder with significant functional and economic impacts. Conventional therapy options, such as topical corticosteroids, calcineurin inhibitors, phototherapy and systemic immunosuppressants, often give unsatisfactory results, due to lack of efficacy or predominant adverse effects. Alitretinoin (9-cis-retinoic acid) is an active substance from the group of retinoids and is licensed as a systemic drug for chronic and severe hand eczema refractory to topical treatment. It binds with high affinity to both retinoic acid receptor (RAR) and retinoid X receptor (RXR) receptors and presents anti-inflammatory and immunomodulatory activity. Due to its good tolerance and high efficacy, demonstrated in several large clinical studies, alitretinoin may be an option for patients with severe chronic hand eczema refractory to other treatment. kontaktowe zapalenie skóry, wyprysk rąk oporny na leczenie, kwas 9-cis-retinowy, alitretynoina.
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