Overview of Salvia miltiorrhiza as a Potential Therapeutic Agent for Various Diseases: An Update on Efficacy and Mechanisms of Action

Jung, In-Yong; Kim, Hyerin; Moon, Sang Won; Lee, Hyuk; Kim, Bonglee

doi:10.3390/antiox9090857

Cited by 63 publications

(25 citation statements)

References 118 publications

(151 reference statements)

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“…About 1000 species belong to this genus and they are herbaceous, suffruticosus or shrubby perennial plants displaying a remarkable diversity in growth forms, in floral morphology and pollination biology, and in secondary metabolites production [ 20 ]. The chemical composition of Salvia species is particularly rich in sesquiterpenoids, diterpenoids, triterpenoids, steroids, polyphenols and others [ 21 , 22 ], and bioactive molecules were reported to exert proapototic and anticancer activities, to act in prevention and treatment of cardiovascular diseases, to be therapeutic in liver diseases, to be active in the central nervous system as a potential cognitive protective, and to prevent or disaggregate beta amyloid and fibrils as inhibitors of acetylcholinesterase [ 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 ].…”

Section: Introductionmentioning

confidence: 99%

Laurus nobilis, Salvia sclarea and Salvia officinalis Essential Oils and Hydrolates: Evaluation of Liquid and Vapor Phase Chemical Composition and Biological Activities

Ovidi

Masci

Zambelli

et al. 2021

Plants

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Laurus nobilis, Salvia officinalis and Salvia sclarea essential oils (EOs) and hydrolates (HYs) were investigated to define their chemical compositions and biological properties. Gas-chromatography/Mass-spectrometry (GC/MS) and Headspace-GC/MS (HS-GC/MS) techniques were used to characterize the liquid and vapor phase chemical composition of EOs and HYs. 1,8-Cineole (42.2%, 33.5%) and α-pinene (16.7%, 39.0%) were the main compounds of L. nobilis EO; 1,8-cineole (30.3%, 48.4%) and camphor (17.1%, 8.7%) were for S. officinalis EO; linalyl acetate (62.6%, 30.1%) and linalool (11.1%, 28.9%) were for S. sclarea EO for the liquid and vapor phase, respectively. Chemical profile of HYs was characterized by 1,8-cineole (65.1%, 61.4%) as a main constituent of L. nobilis and S. officinalis HYs, while linalool (89.5%) was the main constituent of S. sclarea HY. The antioxidant activity of EOs and HYs was carried out by DPPH and ABTS assays and antimicrobial properties were also investigated by microdilution and the disc diffusion method for liquid and vapor phase against five different bacterial strains such as Escherichia coli ATCC 25922, Pseudomonas fluorescens ATCC 13525 and Acinetobacter bohemicus DSM 102855 among Gram-negative and Bacillus cereus ATCC 10876 and Kocuria marina DSM 16420 among Gram-positive. L. nobilis and S. officinalis EOs demonstrated considerable antibacterial activity, while S. sclarea EO proved to be less effective. Agar diffusion method and vapor phase test showed the EOs activity with the biggest halo inhibition diameters against A. bohemicus and B. cereus. A remarkably high antioxidant activity was determined for L. nobilis showing low EC50 values and also for S. sclarea; good EO results were obtained in both of the used assays. S. officinalis EC50 values were slightly higher to which corresponds to a lower antioxidant activity. Concerning the HYs, the EC50 values for L. nobilis, S. officinalis and S. sclarea were remarkably high corresponding to an extremely low antioxidant activity, as also obtained by expressing the values in Trolox equivalent antioxidant capacity (TEAC).

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Section: Introductionmentioning

confidence: 99%

Laurus nobilis, Salvia sclarea and Salvia officinalis Essential Oils and Hydrolates: Evaluation of Liquid and Vapor Phase Chemical Composition and Biological Activities

Ovidi

Masci

Zambelli

et al. 2021

Plants

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“…In China, S. miltiorrhiza is a medicinal plant used to treat cardiovascular and cerebrovascular diseases ( Jung et al, 2020 ), in which the root actinobacteria have previously been reported ( Li et al, 2010 ; Yan et al, 2016 ), but until now, only the Streptomyces have been isolated. Besides, no study has assessed the function of the root-associated actinobacteria of this species.…”

Section: Introductionmentioning

confidence: 99%

Diversity and function of culturable actinobacteria in the root-associated of Salvia miltiorrhiza Bunge

et al. 2021

PeerJ

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The root-associated actinobacteria play important roles in plant growth, nutrient use, and disease resistance due to their functional diversity. Salvia miltiorrhiza is a critical medicinal plant in China. The root actinobacterial community structure has been studied; however, the functions of root-associated actinobacteria of S. miltiorrhiza have not been elucidated. This study aimed to decipher the diversity and function of the culturable root-associated actinobacteria in plant growth using culture-dependent technology and culturable microbe metagenomes. We isolated 369 strains from the root-associated actinobacteria, belonging to four genera, among which Streptomyces was dominant. Besides, the functional prediction revealed some pathways related to plant growth, nitrogen and phosphorus metabolism, and antagonistic pathogens. We systematically described the diversity and functions of the culturable root-associated actinobacteria community. Our results demonstrated that the culturable root-associated actinobacteria of S. miltiorrhiza have rich functionalities, explaining the possible contribution of culturable root-associated actinobacteria to S. miltiorrhiza’s growth and development. This study provides new insights into understanding the function of the culturable root-associated actinobacteria and can be used as a knowledge base for plant growth promoters and biological control agent development in agriculture.

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“…They represent a variety of bioactive compounds that are capable of preventing and controlling diseases related to stress diseases. Thus, the review realized by Jung et al provides an overview of the therapeutic benefits and targets of Salvia miltiorrhiza extracts, including inflammation, fibrosis, oxidative stress, and apoptosis [1]. However, it must be taken into account that the content of polyphenols in plants varies remarkably between species, geographical area, part of the plant tested, etc.…”

mentioning

confidence: 99%

Anti-Inflammatory and Antioxidant Properties of Plant Extracts

Rodríguez-Yoldi

2021

Antioxidants

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Overview of Salvia miltiorrhiza as a Potential Therapeutic Agent for Various Diseases: An Update on Efficacy and Mechanisms of Action

Cited by 63 publications

References 118 publications

Laurus nobilis, Salvia sclarea and Salvia officinalis Essential Oils and Hydrolates: Evaluation of Liquid and Vapor Phase Chemical Composition and Biological Activities

Laurus nobilis, Salvia sclarea and Salvia officinalis Essential Oils and Hydrolates: Evaluation of Liquid and Vapor Phase Chemical Composition and Biological Activities

Diversity and function of culturable actinobacteria in the root-associated of Salvia miltiorrhiza Bunge

Anti-Inflammatory and Antioxidant Properties of Plant Extracts

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