Overview of russian enterosorbents

Zhilyakova, E. T.; Бондарев, А. В.

doi:10.21518/1561-5936-2014-10-40-47

Cited by 5 publications

(3 citation statements)

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“…Mineral adsorbents efficiently bind mycotoxins, which are characterized by poor solubility in water. The adsorption capacity of certain types of clays is due to their layered structure and high sorption area [16][17][18][19][20].…”

Section: Methodsmentioning

confidence: 99%

Clarification of the irritating and toxic effects of bentonite-like clays

Vezentsev¹,

Bukhanov²,

Lopanov³

et al. 2019

Proceedings of the 1st International Symposium Innovations in Life Sciences (ISILS 2019)

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This articlestudies the action and biocompatibility of the developed montmorillonite-containing preparation "Sorbent" on experimental animals with its longterm use. The local irritating effect of the "Sorbent" preparation was evaluated by its effect on the gastric mucosa of animals with experimental ulcerative pathology. The size of the most common particles in the suspension is 5-8 microns. The experiments were carried out on white rats of the Wistar line and non-linear Hartley guinea pigs.To identify the irritating effect, the drug was administered to animals in therapeutic doses of 200 mg/kg and three times the conditionally therapeutic dose -600 mg/kg of body weight. Destructive changes in the stomachs of experimental animals were studied macroscopically. The ulcerogenic effect was evaluated by calculating the Pauls index.

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Section: Methodsmentioning

confidence: 99%

Clarification of the irritating and toxic effects of bentonite-like clays

Vezentsev¹,

Bukhanov²,

Lopanov³

et al. 2019

Proceedings of the 1st International Symposium Innovations in Life Sciences (ISILS 2019)

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“…В технологии получения сорбционных лекарственных систем для использования per os возможно использование только зарегистрированных фарма-цевтических субстанций с адсорбционным фармакологическим действием. На основе проведенного анализа выявлены следующие группы фармацевтических субстанций, разрешенных к применению в медицинской практике (табл.1) [55][56].…”

Section: рисунок 3 -механизм действия сорбционной лекарственной систеunclassified

Use of Sorption Processes in the Technology of Drug Delivery Systems

Бондарев

Жилякова

2019

Farm. farmakol. (Pâtigorsk)

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The aimof this research is the review of scientific and technical literature regarding possibility of using sorption processes in the technology of drug delivery systems.Materials and methods. The materials are the following electronic resources: eLIBRARY, CyberLeninka, PubMed. The methods of review are analysis and synthesis. The study covers the scientific literature from 1996 up to the present time.Results.Sorbents are used as carriers for various medicinal peroral substances, they are also dispensers of various compounds in the form of polymeric eye films and stents in the human body. The delivery of medicinal substances occurs with the help of sorption processes of mass transfer. Currently, the following medical substances are used as carriers for medicinal substances: activated carbon, mineral sorbents (medical clays, synthetic sorbents), polymers and their biosimilars. 6 groups of pharmaceutical substances are registered for the production of enterosorbents in Russia and they can be used as sorbent carriers in the sorption drug system. They are: activated carbon, colloidal silicon dioxide, polyvinylpyrrolidone, dioctahedral smectite, polymethylsiloxane polyhydrate. As a result of the study, the model of the sorption drug system has been developed. It consists of sorbent carrier, active pharmaceutical ingredient and excipients that provide the desorption. Desorption of the active pharmaceutical ingredient may contribute to its modified release. The technology for obtaining sorption medicinal systems requires further study and development of modeling methods, searching for experimental pharmacological models and technological methods, which make it possible to obtain sorption dosage form with modified release.Conclusion.The review of the sorption processes used in the technology of drug delivery systems has been carried out. The model of the sorption drug system has been developed.

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“…Moreover, the biological effect of aluminosilicates can be significantly enhanced by creating therapeutic and prophylactic means on their basis for the treatment of various pathological conditions and metabolic disorders of animals and poultry. The structure of the crystal lattice of aluminosilicates allows loading, transportation and effective release of the pharmacological compounds contained in them, as a result of which it is possible to obtain environmentally friendly medicines with improved antitoxic, hepatoprotective, ion-exchange and antioxidant properties, while preserving the biocompatibility and bioavailability of the components included in them [ 12,13].…”

Section: Introductionmentioning

confidence: 99%

Possibilities of using natural aluminosilicates in the development of medicines at hepatosis in poultry

et al. 2020

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The article discusses the possibility of using natural aluminosilicates as active components of complex medicines at hepatosis in poultry. The use of bentonite from the Kantemirovsky deposit of the Voronezh region in the feed ration of broiler chickens at a dose of 2% helps to improve the general condition of the poultry, the intensity of their growth and productive indicators. In biochemical homeostasis, activation of metabolic processes such as protein, lipid, carbohydrate and mineral is noted. The inclusion of bentonite in the feeding schedule prevents the development of metabolic changes in hepatocytes and their cytolysis, which is confirmed by a decrease in the level of transaminases - AST by 22.9%, ALT by 69.8%, as well as by the accumulation of endogenous toxic substances in the body. The experiment showed that natural bentonites not only provide correction of metabolic homeostasis, but also contribute to the weakening of endotoxemia in the poultry body, showing hepatoprotective and antitoxic effects.

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Overview of russian enterosorbents

Cited by 5 publications

References 0 publications

Clarification of the irritating and toxic effects of bentonite-like clays

Clarification of the irritating and toxic effects of bentonite-like clays

Use of Sorption Processes in the Technology of Drug Delivery Systems

Possibilities of using natural aluminosilicates in the development of medicines at hepatosis in poultry

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