The article discusses the possibility of using natural aluminosilicates as active components of complex medicines at hepatosis in poultry. The use of bentonite from the Kantemirovsky deposit of the Voronezh region in the feed ration of broiler chickens at a dose of 2% helps to improve the general condition of the poultry, the intensity of their growth and productive indicators. In biochemical homeostasis, activation of metabolic processes such as protein, lipid, carbohydrate and mineral is noted. The inclusion of bentonite in the feeding schedule prevents the development of metabolic changes in hepatocytes and their cytolysis, which is confirmed by a decrease in the level of transaminases - AST by 22.9%, ALT by 69.8%, as well as by the accumulation of endogenous toxic substances in the body. The experiment showed that natural bentonites not only provide correction of metabolic homeostasis, but also contribute to the weakening of endotoxemia in the poultry body, showing hepatoprotective and antitoxic effects.
In the course of the experiment on the comparative assessment of selenium-containing preparations selephlan and plexomin Se-2000 in the treatment of white muscle disease in young sheep, it was determined that selephlan has a more pronounced effect on the clinical and physiological state and intestinal biocenosis of lambs, their morphological and biochemical blood parameters, as well as the level of antioxidant protection of the body of animals. Under the influence of the preparation, the erythro- and hematopoiesis is activated in lambs, as well as the normalization of biochemical blood homeostasis. The level of enzymatic activity (AST, ALT, ALP, LDH) significantly decreases in 1.36 (p≤0.05); 1.71 (p≤0.001); 1.21 (p≤0.05) and 1.3 (p≤0.01) times, while the concentration of carotene increases in 3.1 times, vitamin E increases in 1.73 times and vitamin A increases by 26.8%. Selephlan helps to reduce the concentration of DC by 21.8%, KD – by 28.7%, MDA – in 1.61 (p <0.05) times.
The influence of selenolin on the metabolic functions of the liver of laboratory rats was studied on the model of the reproduction of acute liver failure caused by acetaminophen. It was determined that the use of selenolin inhibits and weakens the hepatotoxic effects, contributing to the correction of impaired homeostasis in rats. Under the action of the preparation, there was a decrease in enzymatic activity – AST – in 2.35 times, ALT – in 2.4 times, γ-GGT – by 21.7%, as well as an improvement in protein synthesizing function, manifested by an increase in the concentration of total protein by 26.9%. Selenolin significantly (p <0.05) reduces the level of lipid peroxidation products – DC – in 1.5 times, CD – by 56.3%, MDA – by 19.9%. Due to the organic selenium included in the preparation, selenolin helps to maintain a high activity of the enzyme antioxidant system, which leads to a decrease in the stationary level of free radical and lipid peroxidation products, allowing the body to quickly cope with pathological changes in the liver cells and in the blood homeostasis system.
The article is devoted to the study of the assessment of selenium status in the pathogenesis of liver diseases and the effectiveness of the use of a selenium-containing drug. In the course of studies in animals with clinical signs and high rates of hepatopathies markers – transaminases, in 100% of cases a low level of selenium was revealed – 0.026 ±0.01 μg / ml, because of the increased consumption of this microelement on the background of increased free radical oxidation processes in the liver tissue. It was found that intramuscular administration of the drug selenolin at a dose of 20 mg / 100 kg four times with an interval of 15 days significantly improved the clinical status of the experimental animals; the effectiveness of therapy was 93.3%. Parenteral administration of selenolin favorably corrected the processes of lipid peroxidation and contributed to a significant (p <0.01) decrease in the level of liver indicator enzymes in comparison with the control by 34.5% (aspartate aminotransferase) and by 45.8% (alanine aminotransferase), and also contributed to an increase in the level of selenium to the level of the physiological norm (0.068 ± 0.03 μg / ml).
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