Overview of polyphenols and their properties

Belščak‐Cvitanović, Ana; Durgo, Ksenija; Huđek, Ana; Bačun-Družina, Višnja; Komes, Draženka

doi:10.1016/b978-0-12-813572-3.00001-4

Cited by 106 publications

(144 citation statements)

References 135 publications

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“…Compound 9 Hydroxycinnamic acids and derivatives were previously identified in different mango varieties [20,21]. In the current study, most of the detected hydroxycinnamic acids are found in the form of quinic acid, tartaric acid, and glycosides derivatives, which is because hydroxycinnamic acids mostly present in nature in conjugated with carbohydrates or cyclic alcohol-acid, such as quinic acid [22].…”

Section: Hydroxybenzoic Acid Derivativesmentioning

confidence: 60%

LC-ESI-QTOF/MS Profiling of Australian Mango Peel By-Product Polyphenols and Their Potential Antioxidant Activities

et al. 2019

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Mango (Mangifera indica L.) is one of the most important fruits in the world. Mango peel is an important by-product that is rich in polyphenols and it could have high economic value if it is effectively utilized. Phenolic characterization is an essential step in the commercial utilization of mango peel by-products as food ingredients. Herein, qualitative and quantitative analyses of two Australian mango peel “Keitt” and “Kensington Pride” (K&P) by-products were conducted while using liquid chromatography coupled to electrospray ionisation and quadrupole time of flight mass spectrometry (LC-ESI-QTOF/MS) and high-performance liquid chromatography coupled to photodiode array detector (HPLC-PDA). A total of 98 polyphenols compounds were tentatively identified in both Keitt peel and K&P peel extracts, with greater concentrations of these compounds being detected in Keitt peel. The total phenolic content (TPC), total flavonoid content (TFC), and a total tannin content (TTC) were determined. The antioxidant activity of mango peel by-products was determined while using 2,2-diphenyl-1-picrylhydrazyl (DPPH) antioxidant assay, ferric reducing antioxidant power (FRAP) assay, and 2,2-azino-bis-3-ethylbenzothiazoline-6-sulfonic acid (ABTS) radical scavenging assay. Keitt peel contained higher concentrations of total phenolic compounds, flavonoids, and tannins and had higher antioxidant capacity in DPPH, FRAP, and ABTS assays as compared to K&P peel. In HPLC-PDA quantification, the predominant phenolic compounds in Keitt peel and K&P peel were catechin (62.32 ± 0.01 mg/gd.w.) and syringic acid (17.78 ± 0.01 mg/gd.w).

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Section: Hydroxybenzoic Acid Derivativesmentioning

confidence: 60%

LC-ESI-QTOF/MS Profiling of Australian Mango Peel By-Product Polyphenols and Their Potential Antioxidant Activities

et al. 2019

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“…They represent a preponderant class of phytochemicals, widely distributed among the plant kingdom where more than 8000 phenolic structures are known . Polyphenols are classified by their source of origin, biological function, and chemical structure . According to the chemical structure and the presence of functional groups, polyphenols are generally classified as phenolic acids, flavonoids, and phenolic amides .…”

Section: Polyphenolsmentioning

confidence: 99%

Cholinesterase targeting by polyphenols: A therapeutic approach for the treatment of Alzheimer’s disease

2018

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Alzheimer's disease (AD) is a progressive irreversible neurodegenerative disorder characterized by excessive deposition of β-amyloid (Aβ) oligomers, and neurofibrillary tangles (NFTs), comprising of hyperphosphorylated tau proteins. The cholinergic system has been suggested as the earliest and most affected molecular mechanism that describes AD pathophysiology. Moreover, cholinesterase inhibitors (ChEIs) are the potential class of drugs that can amplify cholinergic activity to improve cognition and global performance and reduce psychiatric and behavioral disturbances. Approximately, 60%-80% of all cases of dementia in the world are patients with AD. In view of the continuous rise of this disease especially in the aged population, there is a dire need to come up with a novel compound and/or mixture that could work against this devastating disease. In this regard, the best is to rely on natural compounds rather than synthetic ones, because natural compounds are easily available, cost-effective, and comparatively less toxic. To serve this purpose, lately, scientific community has started exploring the possibility of using different polyphenols either solitary or in combination that can serve as therapeutics against AD. In the current article, we have summarized the role of various polyphenols, namely quercetin, resveratrol, curcumin, gallocatechins, cinnamic acid, caffeine, and caffeic acid as an inhibitor of cholinesterase for the treatment of AD. We have also tried to uncover the mechanistic insight on the action of these polyphenols against AD pathogenicity.

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“…Synthetic antioxidants can also be used but unfortunately, their use is very restricted [17] [18] [19] [20]. For several years natural antioxidants from fruit and vegetable plants have been widely examined to understand their role in the reduction of ROS in cells [11] [21] [22] [23]. Usually, only fruits and vegetables were consumed for their bioactive components but investigations showed that other organs of the plant (leaves, bark, peelings, roots...) can contain bioactive chemical species, in particular polyphenolic compounds [24] [25] [26].…”

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confidence: 99%

Evaluation of Phenolic Content and Antioxidant Activity of Aqueous Extracts of Three <i>Carica papaya</i> Varieties Cultivated in Senegal

Gaye¹,

Cisse²,

Ndiaye³

et al. 2019

FNS

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The aqueous extracts of different parts (old leaves (OL), young leaves (YL), peels (PE) and delipidated seed residues (DS)) of three varieties of papaya are studied. Extraction conditions are optimized: an extraction time of 20 minutes, a temperature of 70˚C and a plant material/water mixture of 1% give the best yield of polyphenol. The amount of polyphenols, flavonoids, saponins and proanthocyanins of each aqueous extract was investigated. Antioxidant activities are measured using two different methods (DPPH and ABTS). The delipidated seeds (DS) of V1 have the highest total phenolic content (TPC = 72.56 ± 3.16 mg GAE/g) while they have the lowest total flavonoid content (TFC = 0.22 ± 0.01). With regard to saponins, the PE of V3 is much richer in saponins (194.03 ± 15.78 mg AeE/g) than all the other extracts studied. The OL of V2 and PE of V1 contain the most proanthocyanidins with very similar values of 2.51 ± 0.03 mg CE/g and 2.53 ± 0.34 mg CE/g respectively. The study of the antioxidant activities of the extracts showed a correlation between the amount of polyphenols and IC50. DPPH OL and YL V2, which are rich in polyphenols, have the lowest IC50 of 0.072 mg/ml and 0.080 mg/ml respectively, whereas for ABTS we have PE of V1 that is very rich in polyphenols which has the smallest IC50 value of 0.218 mg/ml.

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Overview of polyphenols and their properties

Cited by 106 publications

References 135 publications

LC-ESI-QTOF/MS Profiling of Australian Mango Peel By-Product Polyphenols and Their Potential Antioxidant Activities

LC-ESI-QTOF/MS Profiling of Australian Mango Peel By-Product Polyphenols and Their Potential Antioxidant Activities

Cholinesterase targeting by polyphenols: A therapeutic approach for the treatment of Alzheimer’s disease

Evaluation of Phenolic Content and Antioxidant Activity of Aqueous Extracts of Three <i>Carica papaya</i> Varieties Cultivated in Senegal

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Overview of polyphenols and their properties

Cited by 106 publications

References 135 publications

LC-ESI-QTOF/MS Profiling of Australian Mango Peel By-Product Polyphenols and Their Potential Antioxidant Activities

LC-ESI-QTOF/MS Profiling of Australian Mango Peel By-Product Polyphenols and Their Potential Antioxidant Activities

Cholinesterase targeting by polyphenols: A therapeutic approach for the treatment of Alzheimer’s disease

Evaluation of Phenolic Content and Antioxidant Activity of Aqueous Extracts of Three &lt;i&gt;Carica papaya&lt;/i&gt; Varieties Cultivated in Senegal

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Evaluation of Phenolic Content and Antioxidant Activity of Aqueous Extracts of Three <i>Carica papaya</i> Varieties Cultivated in Senegal