Overview of physical dosimetry methods for triage application integrated in the new European network RENEB

Badie

Barnard

et al. 2016

Self Cite

Purpose: RENEB, 'Realising the European Network of Biodosimetry and Physical Retrospective Dosimetry,' is a network for research and emergency response mutual assistance in biodosimetry within the EU. Within this extremely active network, a number of new dosimetry methods have recently been proposed or developed. There is a requirement to test and/or validate these candidate techniques and inter-comparison exercises are a well-established method for such validation. Materials and methods: The authors present details of inter-comparisons of four such new methods: dicentric chromosome analysis including telomere and centromere staining; the gene expression assay carried out in whole blood; Raman spectroscopy on blood lymphocytes, and detection of radiationinduced thermoluminescent signals in glass screens taken from mobile phones. Results: In general the results show good agreement between the laboratories and methods within the expected levels of uncertainty, and thus demonstrate that there is a lot of potential for each of the candidate techniques. INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, 2017 VOL. 93, NO. 1, 99-109 http://dx.doi.org/10.1080/09553002.2016 Conclusions: Further work is required before the new methods can be included within the suite of reliable dosimetry methods for use by RENEB partners and others in routine and emergency response scenarios.

Section: The Aims Of This Inter-comparison Werecontrasting

confidence: 48%

Integration of new biological and physical retrospective dosimetry methods into EU emergency response plans – joint RENEB and EURADOS inter-laboratory comparisons

Badie

Barnard

et al. 2016

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“…A first inter-comparison on biological and physical dosimetry allowed identification of laboratories requiring training on specific assays Oestreicher et al 2016;Trompier et al 2016a). Furthermore, some laboratories required training on assay(s) that they do not master.…”

Section: Education and Trainingmentioning

confidence: 99%

“…Regarding the EPR assay, the second inter-laboratory comparison has consisted of re-evaluating samples of the first inter-comparison but with alternative approaches. A protocol improvement is still foreseen but more investigations are needed to fully establish the EPR technique on the glass touch screen of a mobile phone (Trompier et al 2016a).…”

Section: Education and Trainingmentioning

confidence: 99%

“…Regarding the retrospective physical dosimetry assay, the two inter-comparisons were planned within Multibiodose project and EURADOS (Trompier et al 2016a). A first interlaboratory comparison was organized on retrospective physical dosimetry for the two assays (EPR and OSL) jointly with the Multibiodose project and EURADOS (Bassinet et al 2014;Fattibene et al 2014).…”

Section: Education and Trainingmentioning

confidence: 99%

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The harmonization process to set up and maintain an operational biological and physical retrospective dosimetry network: QA QM applied to the RENEB network

Grégoire

Barrios

et al. 2016

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Purpose: The European Network of Biological and Physical Retrospective Dosimetry 'RENEB' has contributed to European radiation emergency preparedness. To give homogeneous dose estimation results, RENEB partners must harmonize their processes. Materials and methods: A first inter-comparison focused on biological and physical dosimetry was used to detect the outliers in terms of dose estimation. Subsequently, trainings were organized to improve both tools dose estimation. A second inter-comparison was performed to validate training efficiency. Simultaneously, based on ISO standards, a QA&QM manual on all dosimetry assays was produced which states a common basis and harmonized procedures for each assay. The evaluation of the agreement of RENEB partners to follow the QA&QM manual was performed through a questionnaire. The integration of new members into the network was carried out in the same way, whatever the assays. Results: The training courses on biological and physical dosimetry were judged to be successful because most of the RENEB members' dose estimates improved in the second inter-comparison. The QA&QM manual describes the consensus for the minimum requirements and the performance criteria for both dosimetry assays. The questionnaire revealed that the whole network capacity currently can manage between 15 and 3800 samples once. Conclusion:The methodology used to harmonize all dosimetry practice within the network RENEB was highly successful. The network is operational to manage a mass casualty radiation accident for immediate dose assessment. ARTICLE HISTORY

“…While the first of the exercises was restricted to the network partners, the second intercomparison was open also for potential new members and with regard to the dicentric assay and micronucleus assay also for networks outside Europe. Details and outcome of the intercomparisons are shown in independent articles, included in this special issue, for the dicentric assay , the FISH assay , the micronucleus assay (Depuydt et al 2016), PCC assay , the gamma H2AX assay (Barnard et al 2014;Moquet et al 2016), and for physical dosimetry methods (Trompier et al 2016b), as well as in Fattibene et al (2014) and Bassinet et al (2014).…”

Section: Intercomparisonsmentioning

confidence: 99%

RENEB – Running the European Network of biological dosimetry and physical retrospective dosimetry

Kulka

Abend

et al. 2016

Self Cite

Purpose: A European network was initiated in 2012 by 23 partners from 16 European countries with the aim to significantly increase individualized dose reconstruction in case of large-scale radiological emergency scenarios. Results: The network was built on three complementary pillars: (1) an operational basis with seven biological and physical dosimetric assays in ready-to-use mode, (2) a basis for education, training and quality assurance, and (3) a basis for further network development regarding new techniques and members. Techniques for individual dose estimation based on biological samples and/or inert personalized devices as mobile phones or smart phones were optimized to support rapid categorization of many potential victims according to the received dose to the blood or personal devices. Communication and cross-border collaboration were also standardized. To assure long-term sustainability of the network, cooperation with national and international emergency preparedness organizations was initiated and links to radiation protection and research platforms have been developed. A legal framework, based on a Memorandum of Understanding, was established and signed by 27 organizations by the end of 2015. Conclusions: RENEB is a European Network of biological and physical-retrospective dosimetry, with the capacity and capability to perform large-scale rapid individualized dose estimation. Specialized to handle large numbers of samples, RENEB is able to contribute to radiological emergency preparedness and wider large-scale research projects. ARTICLE HISTORY