Overview of Methods of Making Polyester Nano- and Microparticulate Systems for Drug Delivery

Ahamad, Nadim; Rao, D. Nageswara; Katti, Dhirendra S.

doi:10.1201/b20045-5

Cited by 2 publications

(1 citation statement)

References 116 publications

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“…Biodegradable polymers such as alginate, chitosan, gelatin, polycaprolactone (PCL), polylactic acid (PLA) or poly(lactide-co-glycolide) (PLGA) are the most widely used polymers for the fabrication of nanoparticles. Polymeric nanoparticles can be used to entrap either or both hydrophilic and hydrophobic drug molecules (Ahamad, Rao, & Katti, 2016;Danhier et al, 2012;Nagarwal, Kant, Singh, Maiti, & Pandit, 2009). The composition and surface properties of polymers play an important role in governing drug release kinetics and particle-tissue interaction (Mahaling & Katti, 2016b).…”

Section: Polymeric Nanoparticlesmentioning

confidence: 99%

Fundamentals, challenges, and nanomedicine‐based solutions for ocular diseases

Srinivasarao

Lohiya

Katti

2018

WIREs Nanomed Nanobiotechnol

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The eye consists of sensitive, compactly adjoined tissue structures which act as strong physical (static) and physiological (dynamic) barriers that prevent entry of foreign bodies into the eye. Together, these barriers reduce the bioavailability of topically and intraocularly administered medicaments thus demanding frequent drug administration for the treatment of chronic eye diseases. Hence, development of drug delivery systems (DDS) that can be retained in ocular tissues for longer durations can help to reduce the frequency of drug administration, whereas, delivery systems that traverse through ocular barriers may offer higher bioavailability of administered drugs to otherwise inaccessible ocular tissues. These objectives can be partially/fully achieved using nanoparticulate/colloidal DDS. Colloidal DDS, due to their nanodimensions, undergo internalization by cells which enables transport of drugs through ocular barriers. Furthermore, nanoparticles can prolong duration of drug release and can increase residence time of entrapped cargo molecules in ocular tissues. Together, these aspects facilitate a higher bioavailability, prolonged therapeutic effect and reduced frequency of drug administration for the effective treatment of chronic ocular diseases. Hence, nanocarriers have been widely explored for ophthalmic drug delivery applications. In this review, we discuss the anatomy of ocular tissues along with their barrier properties. We then discuss ocular diseases along with the various routes of drug administration and pathways of drug transport in the eye. The next section discusses the influence of physicochemical properties of therapeutic molecules on their ocular distribution and conventional and advanced (nanoparticulate/colloidal DDS) drug formulations that are used for the treatment of ocular diseases.

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Section: Polymeric Nanoparticlesmentioning

confidence: 99%

Fundamentals, challenges, and nanomedicine‐based solutions for ocular diseases

Srinivasarao

Lohiya

Katti

2018

WIREs Nanomed Nanobiotechnol

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In SituDelivery of Corticosteroids for Treatment of Oral Diseases

Sutera²,

Giannola

2017

Ther. Deliv.

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In many mucocutaneous disorders, corticosteroids therapy is currently central. Systemic therapy is restricted to severe disorders whereas topical applications are considered as the first-line treatment. The oral cavity environment, the medication form and other factors related to the delivery method are key factors for the therapy efficiency and effectiveness. Current marketed medications are not able to avoid wrong drug exposure and scarce patients' compliance. Innovative in situ delivery systems are able to prolong the drug retention time on the mucosa and to avoid the drawbacks of conventional formulations. This review is intended to give a general overview of oral mucocutaneous pathologies and highlight the potential of new technologies in designing innovative delivery systems able to release corticosteroids in situ for the treatment of various oral cavity disorders.

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Overview of Methods of Making Polyester Nano- and Microparticulate Systems for Drug Delivery

Cited by 2 publications

References 116 publications

Fundamentals, challenges, and nanomedicine‐based solutions for ocular diseases

Fundamentals, challenges, and nanomedicine‐based solutions for ocular diseases

In SituDelivery of Corticosteroids for Treatment of Oral Diseases

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