<i>In Situ</i>Delivery of Corticosteroids for Treatment of Oral Diseases

De, Viviana; Sutera, Flavia Maria; Giannola, Libero Italo

doi:10.4155/tde-2017-0055

Cited by 7 publications

(2 citation statements)

References 96 publications

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“…Such kinds of DDS were usually attached to the tooth surface by resin adhesives. To improve the comfort and simplify the operation, BDDS were investigated [90,91]. Researchers have reported bio-adhesive tablets with sustained release of fluoride for hours since 1980s [92].…”

Section: Remineralizing Ddsmentioning

confidence: 99%

Emerging Applications of Drug Delivery Systems in Oral Infectious Diseases Prevention and Treatment

et al. 2020

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The oral cavity is a unique complex ecosystem colonized with huge numbers of microorganism species. Oral cavities are closely associated with oral health and sequentially with systemic health. Many factors might cause the shift of composition of oral microbiota, thus leading to the dysbiosis of oral micro-environment and oral infectious diseases. Local therapies and dental hygiene procedures are the main kinds of treatment. Currently, oral drug delivery systems (DDS) have drawn great attention, and are considered as important adjuvant therapy for oral infectious diseases. DDS are devices that could transport and release the therapeutic drugs or bioactive agents to a certain site and a certain rate in vivo. They could significantly increase the therapeutic effect and reduce the side effect compared with traditional medicine. In the review, emerging recent applications of DDS in the treatment for oral infectious diseases have been summarized, including dental caries, periodontitis, peri-implantitis and oral candidiasis. Furthermore, oral stimuli-responsive DDS, also known as "smart" DDS, have been reported recently, which could react to oral environment and provide more accurate drug delivery or release. In this article, oral smart DDS have also been reviewed. The limits have been discussed, and the research potential demonstrates good prospects.Molecules 2020, 25, 516 2 of 29 problems. For example, systemic antibiotics such as tetracycline, beta-lactam antibiotics, nitroimidazoles have been used, especially in cases of periodontal diseases and peri-implantitis [12]. However, systemic antibiotics could cause problems like drug resistance, dysbacteriosis, and systemic side effects [13,14]. The antibacterial effect is also limited as very little could arrive at the oral lesion area after systemic circulation [15][16][17]. Fluoride in drinking water has been used for the prevention of dental caries but might cause excessive intake, leading to fluorosis [18]. Therefore, local drug therapy is now more considered for oral infectious diseases [19,20]. However, the conventional forms of local therapy, like drug suspension or rinse of anti-infection agents, could be easily washed off and thus could not last long in the oral cavity. Complex local lesions like deep periodontal pockets and teeth fissure are also difficult to reach. In order to improve the effect of prophylaxis and treatment, more precise targeting therapy is quite essential [21,22]. Therefore, drug delivery systems have drawn great attention in recent decades in oral infectious diseases. Drug delivery systems (DDS) are devices that can transport and release the therapeutic agents or bioactive substances to certain sites at certain rates in vivo [23,24], usually composed of the carriers and associated therapeutics [25]. They have been widely explored in biomedical research. With local drug administration and controlled drug release, DDS could provide higher curative efficiency and fewer side effects [23,26,27]. With all these advantages, DDS has been reported w...

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Section: Remineralizing Ddsmentioning

confidence: 99%

Emerging Applications of Drug Delivery Systems in Oral Infectious Diseases Prevention and Treatment

et al. 2020

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“…Recent advances in the basic science of corticosteroids explain the clinical differences of these compounds related to safety and efficacy, by understanding, this can lead to the future discovery of additional novel corticosteroids. 63 In many mucocutaneous disorders, corticosteroid therapy is still the central focus; systemic therapy is limited to severe disorders while the topical therapy still considered as the first line treatment.…”

Section: Future Concernmentioning

confidence: 99%

Treatment with Corticosteroids may Link to Higher Risk of COVID-19 Disease?

Pirzada

Gul

Baig

2021

IJAPSR

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Corticosteroids are one of the important natural hormones released in the body that play a vital role in metabolism due to their intense anti-inflammatory, immunomodulatory and immune suppressive activity. These are most prescribed medications available in various dosage forms like topical formulations, inhalers and injectables. The current outbreak of corona virus disease COVID-19 became a global threat and primary concern worldwide. In respiratory patients, the use of non-steroidal anti-inflammatory drugs (NSAIDs) and corticosteroids exacerbate the disease symptoms of COVID-19 patients, as they are often regarded as immunosuppressive drugs. Inhaled corticosteroids (ICS) are considered as first line treatment of asthma and chronic obstructive pulmonary disease (COPD). COVID-19 disease led the upper respiratory tract illness. ICS are used in the treatment of early symptoms of COVID-19 disease in low doses. Asthmatic patients or patients with chronic obstructive lung disease, who are on regular use of ICS were found to have a low risk of early symptoms of severely ill COVID-19 disease. Although there appeared to be some evidence that corticosteroid therapy may be beneficial in treatment of corona virus disease, but it is also reported to be applicable only at the early acute phase. The literature records revealed that injectable formulations of corticosteroids are known to suppress the immunity in patients infected with SARS-CoV2. The present review is to study the different formulations of corticosteroids and their possible use in COVID-19 progression.

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Polymers in topical delivery of anti-psoriatic medications and other topical agents in overcoming the barriers of conventional treatment strategies

Yadav

Singh

2021

Prog Biomater

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In SituDelivery of Corticosteroids for Treatment of Oral Diseases

Cited by 7 publications

References 96 publications

Emerging Applications of Drug Delivery Systems in Oral Infectious Diseases Prevention and Treatment

Emerging Applications of Drug Delivery Systems in Oral Infectious Diseases Prevention and Treatment

Treatment with Corticosteroids may Link to Higher Risk of COVID-19 Disease?

Polymers in topical delivery of anti-psoriatic medications and other topical agents in overcoming the barriers of conventional treatment strategies

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