Overview of Inherited Zinc Deficiency in Infants and Children

Kambe, Taiho; Fukue, Kazuhisa; Ishida, Riko; Miyazaki, Shiho

doi:10.3177/jnsv.61.s44

Cited by 59 publications

(46 citation statements)

References 22 publications

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“…Breast milk usually contains adequate amounts of zinc for infants up to the age of about six months. In TNZD, however, a mutation in the mother's SLC30A2 gene results in impaired function of the zinc transporter ZnT2 , thus leading to low zinc levels in the breast milk and subsequent zinc deficiency in the breastfed infant (Table ).…”

Section: Acrodermatitis Enteropathica (Ae) and Transient Neonatal Zinmentioning

confidence: 99%

Zinc and skin: an update

Glutsch

Hamm

Goebeler

2019

J Deutsche Derma Gesell

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Summary The essential trace element zinc (Zn) plays a key role in the development, differentiation and growth of various human tissues. Zinc homeostasis is primarily regulated by two zinc transporter families (solute‐linked carrier families, SLC). Disturbances in zinc metabolism may give rise to disorders that typically manifest themselves on the skin. An autosomal recessive zinc deficiency disorder, acrodermatitis enteropathica is caused by a mutation in the gene coding for the ZIP4 transporter. Due to intestinal malabsorption, affected infants develop clinical signs and symptoms shortly after weaning. Acquired zinc deficiency is a rare but underdiagnosed disorder associated with various etiologies and variable clinical manifestations. Depending on the patient's age, a multitude of causes have to be considered. Given the characteristic periorificial and acral lesions, the clinical diagnosis is usually made by dermatologists. Laboratory confirmation includes measurement of plasma zinc levels and – as a supplementary measure – zinc‐dependent enzymes such as alkaline phosphatase. Oral zinc replacement therapy frequently leads to clinical remission within a few days. Depending on the cause, disease management should include cooperation with pediatricians and gastroenterologists in order to guarantee optimal patient care.

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Section: Acrodermatitis Enteropathica (Ae) and Transient Neonatal Zinmentioning

confidence: 99%

Zinc and skin: an update

Glutsch

Hamm

Goebeler

2019

J Deutsche Derma Gesell

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“…48,49 Çocuklarda çinko yetersizliğinin nedenleri arasında diyetle yetersiz alınması, fitatların fazla olması, uzun süreli ishaller ile çinko emilimi ve kullanımını engelleyen çeşitli hastalıklar sayılmak-tadır. 50 Sıfır-bir yaş dönemi için 3 mg/gün çinko öne-rilmektedir. 13 Pakistan'da ve Avustralya'da yapılan çalışmalarda, bebeklerin çinko alımları, sırasıyla 2 mg/gün ve 5,8±2,4 mg/gün olarak bildirilmiştir.…”

Section: Discussionunclassified

Iron, Zinc and Calcium Consumption of 9-12 Months Infants

Yoldaş¹,

Özden²,

Çağatay³

et al. 2016

Turkiye Klinikleri J Health Sci

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8B ebeklik, büyümenin, dolayısıyla enerji ve besin ögesi ihtiyacının fazla olduğu bir dönemdir.1 Bu dönemde organ sistemlerinin hızlı büyüme ve gelişmesi optimal beslenmeyi gerektirmektedir. Bebekler için op-9-12 Aylık Bebeklerde Demir, Çinko ve Kalsiyum Tüketimi Ö ÖZ ZE ET T A Am ma aç ç: : Bu çalışma, 9-12 aylık bebeklerin günlük beslenmeleri ile aldıkları demir, çinko ve kalsiyum minerallerinin miktarlarını belirlemek, önerilerle karşılaştırmak ve gruplar arası farklılıkları incelemek amacıyla yapılmıştır. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : Çalışma 9-12 aylık 243 bebek üzerinde yürü-tülmüştür. Bebeklere ilişkin bilgiler yapılandırılmış bir anket formu ile elde edilmiştir. Bebeklerin vücut ağırlık ve boy uzunluğu ölçümleri alınmış, son 24 saatlik besin tüketimleri kaydedilmiştir. Gün-lük alınan enerji, demir, çinko ve kalsiyum değerleri bilgisayarlı Beslenme Bilgi Sistemi (BeBiS) ile belirlenmiştir. İstatistiksel analizler, SPSS 17.0 programında gerçekleştirilmiştir. B Bu ul lg gu ul la ar r: : Yaş ortalaması 10,5±0,1 ay olan bebeklerin, ağırlık ortalaması 9454±1215 g, boy ortalaması 74,7±3,57 cm olarak bulunmuştur. Bebeklerin %58'i ilk altı ay sadece anne sütü alırken, %3,7'si hiç anne sütü almamaktadır. Bebeklerin %92,6'sının demiri, %18,1'inin çinkoyu, %32,9'unun kalsiyumu günlük önerilen miktarların altında tükettiği belirlenmiştir. Kırmızı et tüketiminin tüm grupta yetersiz olduğu bulunmuştur. Günlük beslenme ile alınan demirin en iyi kaynağının bebe bisküvisi; çinkonun kırmızı et ve inek sütü; kalsiyumun ise inek sütü ve bebe bisküvisi olduğu saptanmıştır. S So on nu uç ç: : Ailelerin, demir, çinko ve kalsiyumun kaynakları konusunda bilgilendirilmesinin ve çocuk beslenmesinde benzer ve daha kapsamlı çalışmaların farklı bölgelerde yapılmasının yararlı olacağı kanısındayız.A An na ah h t ta ar r K Ke e l li i m me e l le er r: : Emzirme; bebek beslenme fizyolojisi fenomenleri; kalsiyum; demir A AB BS S T TR RA AC CT T O Ob bj je ec ct ti iv ve e: : This study was designed to determine the quantity of the iron, zinc and calcium minerals that 9-12 months infants consumed in their daily diet, to compare these values with the recommended ones, and to investigate the differences between the groups. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : 243 infants were included into the study. Families were requested to fill a structured questionnaire in follow-up sessions. Infants' body weight and height measurements were taken. The infants food consumption (24 hours) were recorded. Daily values for energy, iron, zinc and calcium intake were determined by using computerized Nutrient Analyze Program (BeBiS). All statistical analyses were performed using SPSS 17.0. R Re es su ul lt ts s: : Mean age of the babies was 10.5±0.1 months whereas mean weight was 9454±1215 g and mean height was 74.7±3.57 cm. 58% of the babies were fed with breast milk alone for six months, 3% never had breast milk. It was seen that 92.6% of all babies consumed iron below the daily recommended value, this ratio wa...

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“…Acrodermatitis enteropathica is a disease of dermatitis, alopecia, and diarrhea caused by mutations in SLC39A4, a gene essential for dietary Zn absorption. Transient neonatal zinc deficiency is a condition of dermatitis, alopecia, and impaired growth and immune function observed in infants breast-fed by mothers with mutations in SLC30A2, a transporter essential for establishing sufficient Zn levels in breast milk [8]. While genes essential for metal homeostasis have been studied in a variety of contexts other than inherited human disease, the nature of these human diseases highlights that metals must be maintained at sufficient but non-toxic levels for biological processes in the body and that metal homeostasis is achieved by a balance between import and export at both the cell and organ level.…”

Section: Introductionmentioning

confidence: 99%

Characterization of trace metal content in the developing zebrafish embryo

et al. 2017

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Trace metals are essential for health but toxic when present in excess. The maintenance of trace metals at physiologic levels reflects both import and export by cells and absorption and excretion by organs. The mechanism by which this maintenance is achieved in vertebrate organisms is incompletely understood. To explore this, we chose zebrafish as our model organism, as they are amenable to both pharmacologic and genetic manipulation and comprise an ideal system for genetic screens and toxicological studies. To characterize trace metal content in developing zebrafish, we measured levels of three trace elements, copper, zinc, and manganese, from the oocyte stage to 30 days post-fertilization using inductively coupled plasma mass spectrometry. Our results indicate that metal levels are stable until zebrafish can acquire metals from the environment and imply that the early embryo relies on maternal contribution of metals to the oocyte. We also measured metal levels in bodies and yolks of embryos reared in presence and absence of the copper chelator neocuproine. All three metals exhibited different relative abundances between yolks and bodies of embryos. While neocuproine treatment led to an expected phenotype of copper deficiency, total copper levels were unaffected, indicating that measurement of total metal levels does not equate with measurement of biologically active metal levels. Overall, our data not only can be used in the design and execution of genetic, physiologic, and toxicologic studies but also has implications for the understanding of vertebrate metal homeostasis.

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Overview of Inherited Zinc Deficiency in Infants and Children

Cited by 59 publications

References 22 publications

Zinc and skin: an update

Zinc and skin: an update

Iron, Zinc and Calcium Consumption of 9-12 Months Infants

Characterization of trace metal content in the developing zebrafish embryo

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