Overview of different carrier systems for advanced drug delivery

Bandopadhyay, Shantanu; Manchanda, Satish; Chandra, Akhilesh; Ali, Javed; Deb, Pran Kishore

doi:10.1016/b978-0-12-814487-9.00005-3

Cited by 25 publications

(23 citation statements)

References 192 publications

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“…More mechanistic studies will need to be performed to track these ingredients and the potential interactions involved after their ingestion. Moreover, such components, especially surfactants, should be identified as safe, less toxic, and compatible, even at high amounts [ 348 , 349 ]. It is also worth to highlight some drawbacks to which much major attention should be paid, such as the interaction drug-excipients and phenomenon associated with lipid oxidation [ 350 , 351 , 352 ].…”

Section: Challengesmentioning

confidence: 99%

Self-Nano-Emulsifying Drug-Delivery Systems: From the Development to the Current Applications and Challenges in Oral Drug Delivery

et al. 2020

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Approximately one third of newly discovered drug molecules show insufficient water solubility and therefore low oral bio-availability. Self-nano-emulsifying drug-delivery systems (SNEDDSs) are one of the emerging strategies developed to tackle the issues associated with their oral delivery. SNEDDSs are composed of an oil phase, surfactant, and cosurfactant or cosolvent. SNEDDSs characteristics, their ability to dissolve a drug, and in vivo considerations are determinant factors in the choice of SNEDDSs excipients. A SNEDDS formulation can be optimized through phase diagram approach or statistical design of experiments. The characterization of SNEDDSs includes multiple orthogonal methods required to fully control SNEDDS manufacture, stability, and biological fate. Encapsulating a drug in SNEDDSs can lead to increased solubilization, stability in the gastro-intestinal tract, and absorption, resulting in enhanced bio-availability. The transformation of liquid SNEDDSs into solid dosage forms has been shown to increase the stability and patient compliance. Supersaturated, mucus-permeating, and targeted SNEDDSs can be developed to increase efficacy and patient compliance. Self-emulsification approach has been successful in oral drug delivery. The present review gives an insight of SNEDDSs for the oral administration of both lipophilic and hydrophilic compounds from the experimental bench to marketed products.

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Section: Challengesmentioning

confidence: 99%

Self-Nano-Emulsifying Drug-Delivery Systems: From the Development to the Current Applications and Challenges in Oral Drug Delivery

et al. 2020

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“…It is of immense application in the transport of pharmaceutical compounds for the treatment of different ailment. The merit of nanoparticles over other delivery systems is its distinct capacity to administer the right dose of therapeutic formulation at the target site of malfunctiong tissues or cells with less or minimal toxicity to functional tissues or cells [1].…”

Section: Expanse Of Nanotechnologymentioning

confidence: 99%

“…As targeting ligands a broad variety of molecules including proteins, antibodies, antibody fragments, peptides, aptamers or small molecules has been explored in enhancing drug delivery [8,9]. It has been extensively investigated to overcome the barriers to drug delivery, for example, the blood brain barrier (BBB), cell membrane barrier [1,7].…”

Section: Mechanisms Of Drug Deliverymentioning

confidence: 99%

“…topical and intra-muscular. Dosing is preferred in the conventional delivery method as it enhance immediate release (IR) as soon as it get into systemic circulation [1].…”

Section: Introduction 11 Conventional Drug Deliverymentioning

confidence: 99%

“…Trending issues include controlling toxic effect of drugs, pharmacodynamics, amount just needed to produce desired effect with low or no immune reactions. These novel methods needed to achieve these objectives are collectively called Drug Delivery System (DDS) and are a combination of several disciplines such as pharmacy, chemistry, bioconjugate science, polymer chemistry and subatomic Science [1].…”

Section: Introduction 11 Conventional Drug Deliverymentioning

confidence: 99%

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Lipid Based Drug Delivery System: A Review

Zubair

Sheshe

Bashir

et al. 2021

JALSI

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Associated with the old/traditional of method of drug delivery are several limitation ranging from first-pass effect, low tolerance, minimal bioavailability, fluctuation of plasma drug concentration which result to less or no desired effect produced. This call for the demand for a more efficient drug administration technique. Lipid systems are biocompatible, inert and biodegradable, stable and deliver at the target with the desired effect. This paper attempt to describe several types of lipid particles used to deliver drug compounds and their applications as therapeutic agent in treating different clinical condition.

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Aggregation Behavior of Poly(Acrylic acid‐co‐Octadecyl Methacrylate) and Bovine Serum Albumin in Aqueous Solutions

Zhou

et al. 2021

ChemistryOpen

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Polymer-protein complexing systems have been extensively studied because of their wide application in biomedicine and industry. Here, we studied the aggregation behavior of the hydrophobically associating water-soluble polymer poly(acrylic acid-co-octadecyl methacrylate) [P(AA-co-OMA)] prepared with nonionic surfactant as an emulsifier and bovine serum albumin (BSA) in aqueous solution. We identified the optimal composite conditions of P(AA-co-OMA) and BSA aqueous solution. We measured the zeta potential, dynamic light-scattering particle size, and surface tension of P(AA-co-OMA) and BSA mixed aqueous solution. The results showed that the aggregation behavior between the polymer and BSA relied mainly on the hydrophobic interactions between the molecules. In addition, the best compounding condition was 8 wt.% of P(AA-co-OMA) content. The structure of hydrophobically associating polymer P(AA-co-OMA) and its aggregation with BSA were characterized by Fourier-transform infrared spectroscopy. The infrared spectroscopy results identified the hydrogen bonding behavior of the amino and carboxyl groups between the polymer and BSA. This behavior was also confirmed using thermogravimetric analysis and differential scanning calorimetry. The thermal decomposition temperature and melting temperature of BSA changed before and after it was combined with the polymer. We measured the morphology of the polymer BSA aggregate with 8 % polymer content by transmission electron microscopy. The binding mechanism was investigated, as well.

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Overview of different carrier systems for advanced drug delivery

Cited by 25 publications

References 192 publications

Self-Nano-Emulsifying Drug-Delivery Systems: From the Development to the Current Applications and Challenges in Oral Drug Delivery

Self-Nano-Emulsifying Drug-Delivery Systems: From the Development to the Current Applications and Challenges in Oral Drug Delivery

Lipid Based Drug Delivery System: A Review

Aggregation Behavior of Poly(Acrylic acid‐co‐Octadecyl Methacrylate) and Bovine Serum Albumin in Aqueous Solutions

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