Overview of Chronopharmaceutics

Youan, Bi‐Botti C.

doi:10.1002/9780470498392.ch1

Cited by 3 publications

(8 citation statements)

References 331 publications

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“…Intermediate and long cycles are characterized by frequencies ranging from a few hours to a few days, years, decades, centuries, etc. These cycles include the ultradian, circadian, and infradian cycles [12].…”

Section: Types Of Rhythmic Cyclesmentioning

confidence: 99%

“…The frequency of 24 h is characteristic of the circadian cycle which will be discussed in detail later. The infradian cycles have frequencies of more than 24 h and range from days to weeks, months, or years, with the example of the menstrual cycle in women [12,17].…”

Section: Types Of Rhythmic Cyclesmentioning

confidence: 99%

“…CDDSs release API following sigmoid release profile with a specific lag time adapted to the condition [71]. An ideal chronotherapeutic dosage form should have an integrated, time-controlled, and site-specific drug delivery system, regardless of the site of administration [12].…”

Section: Chronotherapy and Chronopharmaceuticsmentioning

confidence: 99%

“…In addition to these advantages, the chronopharmaceutical approach to the treatment of hypertension, but also of other diseases, has certain disadvantages. The most common deficiency is the unpredictable and decreased bioavailability, the possibility of lack of action due to technological errors in the development of these forms, as well as higher economic costs in their development and production [12].…”

Section: Chronotherapy and Chronopharmaceuticsmentioning

confidence: 99%

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Antihypertensives’ Rock around the Clock

Rahić

Tucak

Sirbubalo

et al. 2021

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Although homeostasis is a commonly accepted concept, there is incontrovertible evidence that biological processes and functions are variable and that variability occurs in cycles. In order to explain and understand dysregulation, which has not been embraced by homeostatic principles, the allostatic model has emerged as the first serious challenge to homeostasis, going beyond its homeostatic roots. Circadian rhythm is the predominant variation in the body, and it is a pattern according to which many physiological and pathological events occur. As there is strong experimental and clinical evidence that blood pressure fluctuations undergo circadian rhythm, there is equally strong evidence that targeted time therapy for hypertension provides a better outcome of the disease. The research has gone even further throughout the development and approval process for the use of pulsatile drug release systems, which can be considered as an option for an even more convenient dosage regimen of the medicines needed.

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Section: Types Of Rhythmic Cyclesmentioning

confidence: 99%

Section: Types Of Rhythmic Cyclesmentioning

confidence: 99%

Section: Chronotherapy and Chronopharmaceuticsmentioning

confidence: 99%

Section: Chronotherapy and Chronopharmaceuticsmentioning

confidence: 99%

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Antihypertensives’ Rock around the Clock

Rahić

Tucak

Sirbubalo

et al. 2021

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“…The accumulation of knowledge in this area led to the formation of a new field called chronopharmaceutics, which aims at delivering drugs in a controlled manner at the most appropriate time of the day [18], which in turn leads to the optimization of drugs dosing and their clinical effect. Various drugs and populations were investigated in chronopharmacology research; for example, see Block et al [19].…”

Section: Chronopharmacologymentioning

confidence: 99%

Circadian Models of Serum Potassium, Sodium, and Calcium Concentrations in Healthy Individuals and Their Application to Cardiac Electrophysiology Simulations at Individual Level

Fijorek

Püsküllüoğlu

Polak

2013

Computational and Mathematical Methods in Medicine

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In the article a brief description of the biological basis of the regulation of human biological clocks was presented in order to introduce the role of circadian rhythms in physiology and specifically in the pharmacological translational tools based on the computational physiology models to motivate the need to provide models of circadian fluctuation in plasma cations. The main aim of the study was to develop statistical models of the circadian rhythm of potassium, sodium, and calcium concentrations in plasma. The developed ion models were further tested by assessing their influence on QT duration (cardiac endpoint) as simulated by the biophysically detailed models of human left ventricular cardiomyocyte. The main results are model equations along with an electronic supplement to the article that contains a fully functional implementation of all models.

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Drug Delivery: Oral Route

Singh¹

2015

Encyclopedia of Biomedical Polymers and Polymeric Biomaterials

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Overview of Chronopharmaceutics

Cited by 3 publications

References 331 publications

Antihypertensives’ Rock around the Clock

Antihypertensives’ Rock around the Clock

Circadian Models of Serum Potassium, Sodium, and Calcium Concentrations in Healthy Individuals and Their Application to Cardiac Electrophysiology Simulations at Individual Level

Drug Delivery: Oral Route

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