Drug Delivery: Oral Route

Singh, Brahma N.

doi:10.1081/e-ebpp-120050250

Cited by 10 publications

(12 citation statements)

References 163 publications

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“…Oral route is still a most preferred route with majority of oral drug product available in form of tablets (Jain et al, 2015a;Singh and Kim, 2002). The NIR technology has several benefits that can be effectively utilized for pharmaceutical drug product evaluation.…”

Section: Discussionmentioning

confidence: 99%

Near Infrared Spectroscopy: Basic principles and use in tablet evaluation

Patel

2017

IJCLS

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Abstract:The continuous preference of the oral route for the delivery of the drugs has led the ongoing research in the field of oral delivery. With emergence of Near-infrared spectroscopy (NIRS) as a fast and non-destructive analytical method, researchers have used NIRS for non-destructive evaluation of tablets. This review looks at the basics, theoretical aspects of NIRS, qualitative and quantitative treatment of sample spectra for better understanding of NIRS in tablet evaluation. Use of NIRS in tablet evaluation is discussed in detail with focus on evaluation of tablet hardness, content uniformity and dissolution with use of NIRS. In addition to advantages and limitation of use of NIRS, the current regulatory status and exploration of NIRS as a PAT tool is discussed in the later part of the review.

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Section: Discussionmentioning

confidence: 99%

Near Infrared Spectroscopy: Basic principles and use in tablet evaluation

Patel

2017

IJCLS

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“…The third barrier consists of bicarbonate ions secreted by the surface epithelial cells [77]. One of the major mucosal barrier components against oral delivery of proteins is glycocalyx, which is a fuzzy and fi brous coat that is weakly acidic and consists of sulfated mucopolysaccharides [78]. The digestive enzyme activity of trypsin and chymotrypsin of the duodenum decreases to almost one-half in the jejunum and to one-third in the ileum [79].…”

Section: Mucus Layermentioning

confidence: 99%

Oral insulin delivery – challenges and strategies

Sonia¹,

Sharma²

2014

Oral Delivery of Insulin

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“…Which are enlisted in Table 2. 19,20 Freeze drying (Lyophilization) is a process in which water is sublimed from the product after it is frozen. This technique creates an amorphous porous structure that can dissolve rapidly.…”

Section: Persistent Vomitingmentioning

confidence: 99%

New Technologies in the Formulation of Oral Dispersible Tablets and Taste Masking: A Review

Toor¹,

Kumari²

2018

IRJPS

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In oral drug delivery system (ODDS), drug is administered through the oral route. Oral route is the most preferred and safe route for the delivery of dosage form. Enzymatic degradation of drug and first pass metabolism are the main drawback for this route. One of the tablet taken through this route is Oral dispersible tablet (ODT) is also known as Fast melting, Fast-dispersing, Fast dissolving, Mouth dissolving and Quick disintegrating tablet. These are the tablets which are intended to be placed in the mouth where before swallowing they are get to disperse rapidly. These tablets are made for the fast action basically due to their fast dispersion. ODTs having many merits such as water is not required for swallowing these tablets, having no difficulties for administration to geriatric, paediatric, mentally disabled, and bedridden patients these are having rapid onset of therapeutic action, give good mouth feels, particularly for paediatric patients. Some techniques to prepare ODT are Freeze-drying (Lyophilisation), spray drying, melt granulation, cotton candy process, Phase transition process and direct compression etc. But for these tablets the main challenge is the taste of drug. If the drug having bitter taste it becomes very difficult to take the tablet in this dosage form. However there are many taste masking techniques have been come in focus today to solve this problem. Some of taste masking techniques are such as flavouring and sweetening agents addition, Ion exchange resin,

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Drug Delivery: Oral Route

Cited by 10 publications

References 163 publications

Near Infrared Spectroscopy: Basic principles and use in tablet evaluation

Near Infrared Spectroscopy: Basic principles and use in tablet evaluation

Oral insulin delivery – challenges and strategies

New Technologies in the Formulation of Oral Dispersible Tablets and Taste Masking: A Review

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