New Technologies in the Formulation of Oral Dispersible Tablets and Taste Masking: A Review

Abstract

In oral drug delivery system (ODDS), drug is administered through the oral route. Oral route is the most preferred and safe route for the delivery of dosage form. Enzymatic degradation of drug and first pass metabolism are the main drawback for this route. One of the tablet taken through this route is Oral dispersible tablet (ODT) is also known as Fast melting, Fast-dispersing, Fast dissolving, Mouth dissolving and Quick disintegrating tablet. These are the tablets which are intended to be placed in the mouth where before swallowing they are get to disperse rapidly. These tablets are made for the fast action basically due to their fast dispersion. ODTs having many merits such as water is not required for swallowing these tablets, having no difficulties for administration to geriatric, paediatric, mentally disabled, and bedridden patients these are having rapid onset of therapeutic action, give good mouth feels, particularly for paediatric patients. Some techniques to prepare ODT are Freeze-drying (Lyophilisation), spray drying, melt granulation, cotton candy process, Phase transition process and direct compression etc. But for these tablets the main challenge is the taste of drug. If the drug having bitter taste it becomes very difficult to take the tablet in this dosage form. However there are many taste masking techniques have been come in focus today to solve this problem. Some of taste masking techniques are such as flavouring and sweetening agents addition, Ion exchange resin,