1992
DOI: 10.1517/13543776.2.11.1889
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Overview: Calmodulin and Calmodulin-Antagonists

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Cited by 2 publications
(3 citation statements)
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“…Nine of the twelve compounds belonging to cluster E are composed of poly-cycle rings-containing molecules. Interestingly, Perhexilin maleate (#20) and Prenylamine Lactate (#32) that had been detected as inhibitors by intramolecular BRET probe in the primary screen are both Calmodulin antagonists (Caldirola et al, 1992), and have been confirmed as inhibitors of CAPS-induced TRPV1 activation by APC whatever the voltage used (Fig. 8 and Sup.…”
Section: Resultsmentioning
confidence: 94%
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“…Nine of the twelve compounds belonging to cluster E are composed of poly-cycle rings-containing molecules. Interestingly, Perhexilin maleate (#20) and Prenylamine Lactate (#32) that had been detected as inhibitors by intramolecular BRET probe in the primary screen are both Calmodulin antagonists (Caldirola et al, 1992), and have been confirmed as inhibitors of CAPS-induced TRPV1 activation by APC whatever the voltage used (Fig. 8 and Sup.…”
Section: Resultsmentioning
confidence: 94%
“…This prompted us to perform an in-depth analysis of the literature focusing on these clusters. Strikingly, we found that 12 of the 24 hits belonging to cluster E, G, and J are well-known calmodulin antagonists (Trifluopromazine (#01), Chlorpromazine (#03), Thioridazine (#04); Cyproheptadine (#05); Perphenazine (#06), Loperamide (#11), Clotrimazole (#18), Perhexiline maleate (#20), Quinacrine (#22), Fluphenazine (#23), Felodipine (#28), Prenylamine Lactate (#32)) (Rochette-Egly et al, 1982;Johnson and Wittenauer, 1983;Mannhold et al, 1987;Montero et al, 1991;Caldirola et al, 1992;Hegemann et al, 1993;Xin and Zhang, 1993;Oláh et al, 2007;Lübker and Seifert, 2015).…”
Section: Resultsmentioning
confidence: 99%
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