New calmodulin antagonists of the diphenylalkylamine type. I. Biological activity, SAR and the role of lipophilicity

Stereoselective Conjugate Addition Reactions of α,β-Unsaturated tert-Butyl Esters with Aryllithium Reagents

“…Chiral β,β-diaryl propionic acid derivatives and related compounds have significant and diverse biological activity. This structural element is present in compounds which have reported activities as antiarrhythmics, , vasodilators (Ca-modulin antagonists), , antidepressives, ,, antihistamines, and controllers of cerebral insufficiency . As such, synthetic methods are required for the preparation of a wide variety of compounds of this general structure, ,,,− especially in an optically pure form. ,− In this regard we were attracted to methodology developed by Alexakis involving stereoselective 1,4-addition of lithium diphenyl cuprate to α,β-unsaturated ethyl ester 1 possessing a neighboring chiral controller (chiral imidazolidine) …”