Overprescribing and rational therapeutics: Barriers to change and opportunities to improve

Bennett, Frances; Ferner, Robin E.; Sofat, Reecha

doi:10.1111/bcp.14291

Cited by 12 publications

(13 citation statements)

References 29 publications

(34 reference statements)

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“…13 This has led to a recent increase in prophylactic medications for age-related disorders such as cardiovascular disease and osteoporosis in this age group. 18 Among patients aged 25-79 years, medications were mainly used to treat different medical conditions such as cardiovascular disease, dyslipidaemia, acid reflux disorders, depression and pain. 17 The epidemiology of medication use varies between age groups, so the definition of taking 'too many medications' should also change correspondingly.…”

Section: Multimorbidity In Younger Adultsmentioning

confidence: 99%

Deprescribing for all: a narrative review identifying inappropriate polypharmacy for all ages in hospital settings

et al. 2021

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Patient and public involvement Patients and/or the public were not involved in the design, or conduct, or reporting, or dissemination plans of this research.Patient consent for publication Not required.Ethics approval Ethics approval was obtained from the Ethics Committee.Provenance and peer review Not commissioned; externally peer reviewed.Supplemental material This content has been supplied by the author(s). It has not been vetted by BMJ Publishing Group Limited (BMJ) and may not have been peer-reviewed. Any opinions or recommendations discussed are solely those of the author(s) and are not endorsed by BMJ. BMJ disclaims all liability and responsibility arising from any reliance placed on the content. Where the content includes any translated material, BMJ does not warrant the accuracy and reliability of the translations (including but not limited to local regulations, clinical guidelines, terminology, drug names and drug dosages), and is not responsible for any error and/or omissions arising from translation and adaptation or otherwise.

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Section: Multimorbidity In Younger Adultsmentioning

confidence: 99%

Deprescribing for all: a narrative review identifying inappropriate polypharmacy for all ages in hospital settings

et al. 2021

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“…The main factors contributing to the emergence of antibiotic-resistant bacteria is an excessive consumption in the treatment of various diseases, as well as the use of antibiotics in animal husbandry [2]. At the same time, the time of emergence of resistance to new antibacterial drugs was significantly reduced [3,4] Several researchers report that the main reason for the formation of bacterial resistance to many antimicrobial agents used is the production of R plasmids when conjugated from other bacteria [5][6][7][8], which contain antibiotic resistance genes. They can be transmitted from one bacterium to another, forming resistance in the entire population.…”

Section: Introductionmentioning

confidence: 99%

Studies on genes expression pattern of antioxidant enzymes and enzymes involved into the genetic information implementation in E.coli cells due to the antibiotic resistance against apramycin and cefatoxime

et al. 2020

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The emergence of antibiotic-resistant bacteria is considered a serious problem. The resistance of bacteria against antimicrobial substances becomes important in the repair systems for damage to DNA and RNA molecules. The role of the antioxidant system in the development of bacterial resistance against antibiotics is not yet practically studied. The article studied the expression regulation of the genes of antioxidant enzymes and enzymes involved in the genetic information in E. coli cells with the antibiotic resistance against apramycin and cefatoxime. The study was conducted on bacterial cells resistant against these two antibiotics. The genes blaOXA-1, blaSHV, blaTEM, mdtK, aadA1, aadA2, sat, strA, blaCTX, blaPER-2, tnpA, tnpR, intC1 and intC1c were identified in bacterial cell case. This indicates the presence of plasmids in bacteria with these genes, which provide bacterial resistance to apramycin and cefatoxime. It was established that during the formation of cefotaxime resistance, there was a sharp increase in the expression of the Cu, Zn superoxide dismutase gene: in comparison with the control group, the representation of its transcripts increased 141.04 times for cefotoxime and 155.42 times for apramycin. It has been established that during the formation of resistance to the studied antibiotics in E. coli, an increase in the expression of the end4 and end3 genes is observed. There is tendency toward an increase in the number of transcripts of the pol3E gene observed in the formation of resistance against cefotaxime and apromycin.

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“…[7][8][9] The development of compounds with the ability to inhibit bacterial growth has been of great interest in recent years. [10] Even though pharmacological industries have produced a number of new antibiotics in the last three decades, resistance to these drugs by microorganisms has increased. The problem of microbial resistance is growing and the outlook for the use of antimicrobial drugs in the future is still uncertain.…”

Section: Introductionmentioning

confidence: 99%

Spectral, crystallographic, theoretical and antibacterial studies of palladium(II)/platinum(II) complexes with unsymmetric diphosphine ylides

Sabounchei

Badpa

Bayat

et al. 2018

Applied Organom Chemis

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The reaction of α‐keto‐stabilized diphosphine ylides [Ph2P(CH2)nPPh2═C(H)C(O)C6H4‐p‐CN] (n = 1 (Y1); n = 2 (Y2)) with dibromo(1,5‐cyclooctadiene) palladium(II)/platinum(II) complexes, [Pd/PtBr2(cod)], in equimolar ratio gave the new cyclometalated Pd(II) and Pt(II) complexes [Br2Pd(κ2‐Y1)] (1), [Br2Pt(κ2‐Y1)] (2), [Br2Pd(κ2‐Y2)] (3) and [Br2Pt(κ2‐Y2)] (4). These compounds were screened in a search for novel antibacterial agents and characterized successfully using Fourier transfer infrared and NMR (1H, 13C and 31P) spectroscopic methods. Also, the structures of complexes 1 and 2 were characterized using X‐ray crystallography. The results showed that the P,C‐chelated complexes 1 and 2 have structures consisting of five‐membered rings, while 3 and 4 have six‐membered rings, formed by coordination of the ligand through the phosphine group and the ylidic carbon atom to the metal centre. Also, a theoretical study of the structures of complexes 1–4 was conducted at the BP86/def2‐SVP level of theory. The nature of metal–ligand bonds in the complexes was investigated using energy decomposition analyses (EDA) and extended transition state combined with natural orbitals for chemical valence analyses. The results of EDA confirmed that the main portions of ΔEint, about 57–58%, in the complexes are allocated to ΔEelstat.

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Overprescribing and rational therapeutics: Barriers to change and opportunities to improve

Cited by 12 publications

References 29 publications

Deprescribing for all: a narrative review identifying inappropriate polypharmacy for all ages in hospital settings

Deprescribing for all: a narrative review identifying inappropriate polypharmacy for all ages in hospital settings

Studies on genes expression pattern of antioxidant enzymes and enzymes involved into the genetic information implementation in E.coli cells due to the antibiotic resistance against apramycin and cefatoxime

Spectral, crystallographic, theoretical and antibacterial studies of palladium(II)/platinum(II) complexes with unsymmetric diphosphine ylides

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