Overexpression or ectopic expression of MUC2 is the common property of mucinous carcinomas of the colon, pancreas, breast, and ovary

Hanski, C.; Hofmeier, M.; Schmitt-Gräff, A.; Riede, E.; Hanski, Marie‐Luise; Borchard, F; Sieber, E; Niedobitek, F; Foss, Hans‐Dieter; Stein, Harald; Riecken, Ernst–Otto

doi:10.1002/(sici)1096-9896(199708)182:4<385::aid-path861>3.0.co;2-q

Cited by 127 publications

(90 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Of the chromosome 11 mucins, MUC2 expression has been most extensively studied in colorectal malignancy where it is commonly downregulated both at the mRNA and protein levels, 16,38,39 except in tumors displaying a mucinous phenotype. 19,20,40 Various immunohistochemical studies have reported MUC2 positivity in colorectal cancers ranging from 21 to 63%. 19,39,[41][42][43] MUC5AC expression has been reported in 13-64% carcinomas, 16,42,44,45 with highest levels of expression in microsatellite-unstable/mismatch repair-deficient tumors 18,19,46 and those showing characteristic mucinous phenotype.…”

Section: Discussionmentioning

confidence: 99%

Expression of MUC2, MUC5AC, MUC5B, and MUC6 mucins in colorectal cancers and their association with the CpG island methylator phenotype

et al. 2013

View full text Add to dashboard Cite

Mucinous differentiation is associated with both CpG island methylator phenotype and microsatellite instability in colorectal cancer. The mucinous phenotype derives from abundant expression of the colonic goblet cell mucin, MUC2, and de novo expression of gastric foveolar mucin, MUC5AC. We, therefore, investigated the protein expression levels of MUC2 and MUC5AC, as well as MUC5B and MUC6, in molecular subtypes of colorectal cancer. Seven-hundred and twenty-two incident colorectal carcinomas occurring in 702 participants of the Melbourne Collaborative Cohort Study were characterized for methylator status, MLH1 methylation, somatic BRAF and KRAS mutations, microsatellite-instability status, MLH1, MSH2, MSH6, and PMS2 mismatch repair, and p53 protein expression, and their histopathology was reviewed. Protein expression levels of MUC2, MUC5AC, MUC5B, MUC6, and the putative mucin regulator CDX2 were compared with molecular and clinicopathological features of colorectal cancers using odds ratios and corresponding 95% confidence intervals. MUC2 overexpression (425% positive tumor cells) was observed in 33% colorectal cancers, MUC5B expression in 53%, and de novo MUC5AC and MUC6 expression in 50% and 39%, respectively. Co-expression of two or more of the mucins was commonly observed. Expression of MUC2, MUC5AC and MUC6 was strongly associated with features associated with tumorigenesis via the serrated neoplasia pathway, including methylator positivity, somatic BRAF p.V600E mutation, and mismatch repair deficiency, as well as proximal location, poor differentiation, lymphocytic response, and increased T stage (all Po0.001). Overexpression was observed in tumors with and without mucinous differentiation. There were inverse associations between expression of all four mucins and p53 overexpression. CDX2 expression was inversely associated with MUC2, MUC5AC and MUC6 expression. Our results suggest that, in methylator-positive tumors, mucin genes on chromosome 11p15.5 region undergo increased expression via mechanisms other than direct regulation by CDX2.

show abstract

Section: Discussionmentioning

confidence: 99%

Expression of MUC2, MUC5AC, MUC5B, and MUC6 mucins in colorectal cancers and their association with the CpG island methylator phenotype

et al. 2013

View full text Add to dashboard Cite

show abstract

“…20 MUC1, 2, and 5 are secretory mucins variably expressed in the gastrointestinal and respiratory tracts. [21][22][23][24][25][26] The expression of or absence of epithelial intermediate filaments CK7 and CK20 are commonly utilized to separate colorectal from other primary adenocarcinomas especially lung. [27][28][29] The six cases of primary pulmonary intestinal-type adenocarcinomas were compared to age-and sex-matched metastatic colonic adenocarcinomas of lung to investigate their staining properties with regard to these antigens and their applicability to the differential diagnosis.…”

mentioning

confidence: 99%

Pulmonary intestinal-type adenocarcinoma does not show enteric differentiation by immunohistochemical study

Yousem

2005

Modern Pathology

View full text Add to dashboard Cite

Six cases of an unusual variant of primary pulmonary adenocarcinoma resembling colorectal and sinonasal adenocarcinoma are presented. Pulmonary intestinal-type adenocarcinoma occurs in elderly Caucasians and is associated with a histology characteristic of colorectal/enteric adenocarcinoma: a garland-like architecture with a 'gland in gland' periphery, central 'dirty' necrosis, and elongated stratified columnar cells, lacking significant goblet or signet ring differentiation. While a resemblance to intestinal adenocarcinoma by light microscopy is present, immunohistochemical studies comparing these carcinomas with metastatic colorectal adenocarcinoma clearly show a respiratory phenotype with the neoplastic cells expressing thyroid transcription factor-1 and cytokeratin 7 to the exclusion of cytokeratin 20, and failing to express CDX-2. Stains for a variety of epithelial mucins (MUC1, MUC2, MUC5AC) also support this observation. The differential diagnosis with other pulmonary adenocarcinomas, especially those with mucinous differentiation, is discussed.

show abstract

“…Mucin secreted by such tumor is O-acylated forms of sialomucin 13 . The mucin secreted has been found to be positive for MUC 2 and low level of MUC 1 14 . A very small proportion (<5%) of Mucinous carcinoma has been showing positivity for MUC 5 15 .…”

Section: Case Report Discussionmentioning

confidence: 99%

Mucinous carcinoma of breast: FNAC as effective diagnostic modality

et al. 2013

View full text Add to dashboard Cite

Mucinous carcinoma of the breast in pure form comprises only 2% of all breast cancers. Pure mucinous carcinoma of the breast have better prognosis. They are usually having higher incidence in peri-menopausal and post-menopausal age group. We report a 32-year-old female, clinically suspected to have benign breast disease, diagnosed as mucinous carcinoma of the breast on FNAC. In such cases, there is always a high probability of missing the diagnosis at imaging because of the absence of established radiological signs of malignancy such as calcification and spiculation. In this case imaging was not helpful and diagnosis was ascertained by FNAC. This case further strongly substantiates, Fine needle aspiration cytology as rapid , highly sensitive and highly specific diagnostic investigation of choice for management of breast lumps .

show abstract

Overexpression or ectopic expression of MUC2 is the common property of mucinous carcinomas of the colon, pancreas, breast, and ovary

Cited by 127 publications

References 22 publications

Expression of MUC2, MUC5AC, MUC5B, and MUC6 mucins in colorectal cancers and their association with the CpG island methylator phenotype

Expression of MUC2, MUC5AC, MUC5B, and MUC6 mucins in colorectal cancers and their association with the CpG island methylator phenotype

Pulmonary intestinal-type adenocarcinoma does not show enteric differentiation by immunohistochemical study

Mucinous carcinoma of breast: FNAC as effective diagnostic modality

Contact Info

Product

Resources

About