Mucinous carcinoma of breast: FNAC as effective diagnostic modality

Tyagi, Ruchita; Kumar, Mahendra; Tanwar, Pranay; Dey, Pranab

doi:10.3126/ajms.v3i3.5240

Cited by 2 publications

(3 citation statements)

References 15 publications

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“…SRC, mucinophages, and MVF were rarely observed. [5][6][7] Review of the literature revealed majority of the published literature pertaining to the cytological diagnosis MC are single case reports with only few series available. [6][7][8][9][10] Adhikari et al 7 studied eight cases of MC (5 PMC + 3 MMC) and observed presence of ECM along with single and cluster of tumor cells floating in them and thin walled capillaries as prominent features in five cases of PMC.…”

Section: Discussionmentioning

confidence: 99%

“…Due to the distinct clinicopathological parameters their exists prognostic difference between PMC and MMC. [1][2][3][4] Even though fine needle aspiration cytology (FNAC) is well accepted as initial diagnostic modality for breast cancer, 5 the cytological features of PMC are less defined. Cytological diagnosis of PMC is challenging as the features overlap with many benign and malignant lesions.…”

Section: Introductionmentioning

confidence: 99%

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Clinicopathological Study of Mucinous Carcinoma of Breast with Emphasis on Cytological Features: A Study at Tertiary Care Teaching Hospital of South India

Chikkannaiah¹,

Thangngeo²,

Guruprasad³

et al. 2020

J Lab Physicians

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Introduction Mucinous carcinoma (MC) is a rare form of breast cancer. It accounts for 1 to 7% of the cases and characterized by the presence of extracellular mucin (ECM). Depending on the amount of mucin, it is classified into pure mucinous carcinoma (> 90%, PMC) and mixed mucinous carcinoma (MMC; < 90%). In comparison to most common subtypes, MC is having better prognosis. There exist clinicopathological differences among PMC and MMC and also MC and IDC-NOS. Materials and Methods MCs diagnosed between January 2012 and December 2017 were included. Fine needle aspiration cytology smears were screened for cellularity, ECM, nuclear pleomorphism, signet ring cells (SRC), mucinophages, and myxovascular fragments (MVF). Histopathology slides were screened to confirm the diagnosis. Immunohistochemistry slides were graded as per the standard protocol. Statistical analyses were performed by SPSS software. Results In the present study, MC constituted 3.3%. The mean age of the patients was 50.9 years. ECM, mucinophages, and SRC were the key diagnostic cytological features. The PMC and MMC were clinicopathologically distinct with respect to gross findings and lymph node status. MMCs were highly proliferative. The mean duration of follow-up was 24.5 months. Complications were more common in MMC than PMC. Lymph node involvement is the key prognostic factor and it is independent of other prognostic factors like age, size, and hormonal receptor status. Conclusion PMC are rare subtype of breast cancer. The diagnostic cytological features are ECM, MVF, and SRC. MMC and PMC are clinicopathologically and genetically distinct.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Clinicopathological Study of Mucinous Carcinoma of Breast with Emphasis on Cytological Features: A Study at Tertiary Care Teaching Hospital of South India

Chikkannaiah¹,

Thangngeo²,

Guruprasad³

et al. 2020

J Lab Physicians

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“…MC has better prognosis (90% survival at 10 years) and higher incidence in perimenopausal and postmenopausal age groups. The incidence of MC in women under 35 years of age is only 1% [1,6-8]. MC is a slow-growing tumor, with an estimated growth rate of one third of that of IDC.…”

Section: Discussionmentioning

confidence: 99%

Pure mucinous carcinoma of the breast: clinicopathologic characteristics and long-term outcome among Taiwanese women

et al. 2013

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BackgroundPure mucinous carcinoma (MC) is found in about 3.5% of all newly diagnosed breast cancer patients in Taiwan. MC is a relatively rare malignancy of breast cancer, and its nature, behaviors, treatment pattern and long-term follow-up are not well understood. The study aimed to investigate the incidence rate, treatment patterns, and prognostic factors of MC of the breast and the clinical long-term outcomes compared with infiltrating ductal carcinoma not otherwise specified (IDC) in the middle and south Taiwanese women.MethodsData from 93 patients with breast MC were retrospectively reviewed and the clinicopathologic characteristics and survival status were compared with those of 2,674 patients with IDC.ResultsThe expression of hormonal receptor was higher in MC than those in IDC (P <0.001). MC also demonstrated lower Her2/neu gene over-expression (P = 0.023), less axillary lymph node involvement (P <0.0001), lymphovascular invasion (P <0.0001) and higher 10-year overall survival rate (P = 0.042), when compared with those of IDC.ConclusionOur data confirm the less aggressive behavior of MC compared to IDC. MC showed favorable clinicopathologic characteristics in tumor grade, hormone receptor status and lymph node involvement in the middle and south Taiwanese women.

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Mucinous carcinoma of breast: FNAC as effective diagnostic modality

Cited by 2 publications

References 15 publications

Clinicopathological Study of Mucinous Carcinoma of Breast with Emphasis on Cytological Features: A Study at Tertiary Care Teaching Hospital of South India

Clinicopathological Study of Mucinous Carcinoma of Breast with Emphasis on Cytological Features: A Study at Tertiary Care Teaching Hospital of South India

Pure mucinous carcinoma of the breast: clinicopathologic characteristics and long-term outcome among Taiwanese women

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