Overexpression of Tumour Necrosis Factor Α in the Brain of Transgenic Mice Differentially Alters Nerve Growth Factor Levels and Choline Acetyltransferase Activity

The neurite growth inhibitory effects of soluble TNFα on developing sympathetic neurons are dependent on developmental age

“…Furthermore, we have recently show that LPS-induced maternal inflammation at later gestational ages, but not early ones adversely affect the growth of developing neurons in affected offspring (Straley et al, 2014). As constitutive overexpression of TNFα can alter the levels of NGF in the nervous system (Aloe et al, 1999), as well as inhibit neurite growth, this suggests that given these current findings, it will be important in future work to examine the effect of maternal inflammation at different stages of development on neurite growth and target innervation in the developing foetal nervous system.…”

Updates in the pathophysiological mechanisms of Parkinson’s disease: Emerging role of bone marrow mesenchymal stem cells

“…It has been postulated that there is a balance between cytokine and neurotrophin in the brain and disruption of this balance cause injurious changes in the CNS [54] . Moreover, Borchelt [55] observed that astrocytes stimulated by mediators released from microglia down-regulate neurotrophic factors expression and release additional inflammatory mediators that in turn activate microglia.…”

POSSIBLE THERAPEUTIC ROLE OF <I>JASONIA CANDICANS</I> AND <I>JASONIA MONTANA</I> EXTRACTS IN THE REGRESSION OF ALZHEIMER’S DISEASE IN EXPERIMENTAL MODEL

“…It has been proposed that there is a cytokine/neurotrophin balance in the brain and the disruption in this balance leads to detrimental change in CNS (Aloe et al, 1999). Aluminum has been found to cause a shift in this balance towards increased pro-inflammatory cytokine production.…”