Overexpression of thymic stromal lymphopoietin in allergic rhinitis

Mou, Zhonglin; Xia, Jiahong; yenong, tan; Wang, Xiangdong; Zhang, Yuan; Zhou, Bing; Li, Hua-Bin; Han, Demin

doi:10.1080/00016480802225884

Cited by 91 publications

(70 citation statements)

References 19 publications

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“…Additionally, several genome-wide studies have found polymorphisms in the TSLP gene that are associated with asthma pathophysiology (Harada et al 2009;Harada et al 2011;Hunninghake et al 2010). Elevated levels of TSLP have also been linked to allergic rhinitis (Miyata et al 2008;Mou et al 2009), food and pollen allergy (Blázquez et al 2010;Zhu et al 2009), and allergic (kerato) conjunctivitis (Matsuda et al 2010;Zheng et al 2010). TSLP may therefore play a pivotal role in the initiation of allergic disease and contribute to the pathophysiology of asthma, rhinitis, and atopic dermatitis.…”

Section: Thymic Stromal Lymphopoietin (Tslp)mentioning

confidence: 99%

Cytokine Pathways in Allergic Disease

et al. 2012

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Cytokines are critical in allergic intercellular communication networks, and they contribute to disease pathology through the recruitment and activation of pro-inflammatory leukocytes and in chronic disease to pro-fibrotic/remodeling events. Th2 cytokines predominate primarily in mild to moderate allergic asthma, although clinical trials with inhibitors of IL-4 and IL-5 have not provided the robust efficacy observed in animal models of allergy. These results not only highlight the complexity of allergic disease, but they also point to the importance of other cytokine networks in driving pathology. The heterogeneous nature of the disease is emphasized by the fact that the Th2/Th1/Th17 cytokine balance can be influenced by the initiating allergic trigger. For example, the house dust mite allergen Der p 2 mimics the activity of MD-2 by presenting lipopolysaccharide to Toll-like receptor-4 for the activation of inflammatory genes including innate-type cytokines. Here we discuss the functions of the novel cytokine players, thymic stromal lymphopoetin (TSLP), IL-33, IL-25, and IL-9 and delineate nonredundant roles for IL-4 and IL-13 in allergic disease. Persistent efforts in the characterization of these and other cytokine networks will be essential for understanding the complex pathogenic mechanisms that underpin allergic disease and for guiding targeted therapeutic interventions.

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Section: Thymic Stromal Lymphopoietin (Tslp)mentioning

confidence: 99%

Cytokine Pathways in Allergic Disease

et al. 2012

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“…Although the level of TSLP expression can be variable in asthmatic patients, it has been shown to correlate directly with TH2 cytokine and chemokine expression and inversely with lung function (Shikotra et al 2011 ;Ying et al 2008 ). Increased expression of TSLP in the nasal epithelium has also been found in biopsies from allergic rhinitis patients and was associated with TH2 cytokine production and eosinophilic infi ltration in epithelial-associated tissue (Mou et al 2009 ;Kamekura et al 2009 ;Kimura et al 2011 ;Xu et al 2010 ). Genetic studies also support a critical role for TSLP in allergic airway disease.…”

Section: Respiratory Diseasesmentioning

confidence: 89%

Thymic Stromal Lymphopoietin (TSLP)

et al. 2013

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Originally shown to promote the growth and activation of B cells, thymic stromal lymphopoietin (TSLP) is now known to have wide-ranging impacts on both hematopoietic and nonhematopoietic cell lineages, including dendritic cells (DCs), basophils, eosinophils, mast cells, CD4 + , CD8 + , and natural killer (NK) T cells, B cells, and epithelial cells. Although the role of TSLP in the promotion of TH2 responses has been extensively studied in the context of lung-and skin-specifi c allergic disorders, it is becoming increasingly clear that TSLP may impact multiple disease states within multiple organ systems, including the blockade of TH1/TH17 responses and the promotion of cancer and autoimmunity. This review will highlight recent advances in the understanding of TSLP signal transduction, as well as the role of TSLP in allergy, autoimmunity, and cancer. Importantly, these insights into TSLP's multifaceted roles could potentially allow for novel therapeutic manipulations of these disorders.

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“…mRNA and protein expression of TSLP have been found to be increased in the nasal mucosa of patients with AR compared to normal controls, and TSLP protein expression has been strongly correlated with IL-4 and the severity of AR [34]. One study investigated the association of SNPs in TSLP with allergy in children with asthma [19].…”

Section: Discussionmentioning

confidence: 99%

The Genetic Variants of Thymic Stromal Lymphopoietin Protein in Children with Asthma and Allergic Rhinitis

Birben

Şahiner²,

Karaaslan³

et al. 2014

Int Arch Allergy Immunol

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Background: Thymic stromal lymphopoietin (TSLP) is expressed by airway epithelial cells and plays a key role in immunological events in asthma. Data on the genetic variants of TSLP and its association with asthma and allergic rhinitis are scarce. We aimed to investigate the effects of the genetic variants of TSLP in children with asthma and allergic rhinitis. Methods: The genetic variants of the TSLP gene were determined by sequencing 25 asthmatic and 25 healthy children. In an association study, a population of 506 asthmatics and 157 healthy controls was screened for the following single-nucleotide polymorphisms (SNPs): rs3806933 and rs2289276 in the promoter region; rs11466741, rs11466742, and rs2289278 in intron 2; rs10073816, rs11466749, and rs11466750 in exon 4, and rs11466754 in 3′-UTR. Results: In Multifactor Dimensionality Reduction analysis, presence of the rs11466749 AA genotype with atopy was significantly associated with a diagnosis of asthma (testing set accuracy: 0.720 and cross validation: 9/10). Two functional SNPs showed a gender-specific association with allergy, i.e. the rs3806933 CC genotype with asthma in boys (p = 0.032, nonsignificant after multiple testing) and the rs2289276 CC genotype with higher eosinophil numbers in asthmatic girls (p = 0.003). The presence of allergic rhinitis in asthmatic children strengthened the association of the rs11466749 GG genotype with asthma (p = 0.001), and rs2289276 was significantly associated with lower FEV₁ levels in asthmatics without allergic rhinitis (p = 0.003). Conclusion: Variants in the gene encoding the TSLP protein may have differential effects on asthma phenotypes depending on gender, atopy, and the presence of allergic rhinitis.

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Overexpression of thymic stromal lymphopoietin in allergic rhinitis

Abstract: TSLP was detected in all samples and the mRNA and protein expression of TSLP is increased significantly in AR nasal mucosa compared with normal control (P<0.05). TSLP production is tightly correlated with IL-4 and severity of AR (P<0.05).

Cited by 91 publications

References 19 publications

Cytokine Pathways in Allergic Disease

Cytokine Pathways in Allergic Disease

Thymic Stromal Lymphopoietin (TSLP)

The Genetic Variants of Thymic Stromal Lymphopoietin Protein in Children with Asthma and Allergic Rhinitis

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