Thymic Stromal Lymphopoietin (TSLP)

Abstract

Originally shown to promote the growth and activation of B cells, thymic stromal lymphopoietin (TSLP) is now known to have wide-ranging impacts on both hematopoietic and nonhematopoietic cell lineages, including dendritic cells (DCs), basophils, eosinophils, mast cells, CD4 + , CD8 + , and natural killer (NK) T cells, B cells, and epithelial cells. Although the role of TSLP in the promotion of TH2 responses has been extensively studied in the context of lung-and skin-specifi c allergic disorders, it is becoming increasingly clear that TSLP may impact multiple disease states within multiple organ systems, including the blockade of TH1/TH17 responses and the promotion of cancer and autoimmunity. This review will highlight recent advances in the understanding of TSLP signal transduction, as well as the role of TSLP in allergy, autoimmunity, and cancer. Importantly, these insights into TSLP's multifaceted roles could potentially allow for novel therapeutic manipulations of these disorders.

Differences between peptide profiles of extensive hydrolysates and their influence on functionality for the management of cow's milk allergy: A short review

“…Recent studies, in both humans and mouse models, have implicated thymic stromal lymphopoietin (TSLP) in the development and progression of allergic diseases as one of the cytokines that is involved in driving allergic inflammatory responses ( 26 ). Interleukin-33 (IL-33) is a member of the IL-1 cytokine family that has been widely studied for its dichotomous functions in homeostasis and inflammation ( 27 ).…”