Overexpression of Sirtuin 1 protein in neurons prevents and reverses experimental diabetic neuropathy

Chandrasekaran, Krish; Salimian, Mohammad; Konduru, Sruthi R; Choi, Joungil; Kumar, Pranith; Long, Aaron; Klimova, Nina; Ho, Cheng-Ying; Kristián, Tibor; Russell, James W.

doi:10.1093/brain/awz324

Cited by 57 publications

(64 citation statements)

References 101 publications

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“…Several studies demonstrated that sirtuins plays a crucial role on aging, neural disorders and metabolic syndrome ( Brachmann et al, 1995 ; Smith et al, 2000 ). Considering the 7 mammalian sirtuins, the overexpression of SIRT1 and/or its stimulation by certain natural chemical structures (resveratrol for instance), enhance health and life span ( Chandrasekaran et al, 2019 ). SIRT1 modulates several gene components, however there are some priority transcription factors.…”

Section: Sirtuins and Brainmentioning

confidence: 99%

“…The authors suggested a mitophagia associated with NEDD4 that improves mitochondrial breathing capacity, increasing axonal development and reparation. SIRT1 is essential to this route by regulating mitochondrial role in the marginal nerve throughout PGC1-α modulation ( Chandrasekaran et al, 2019 ). Cell culture researches showed that SIRT1 is detect in the nucleus of several cell lines ( Michan and Sinclair, 2007 ) producing deacetylation activity of several transcription factors.…”

Section: Sirtuins and Brainmentioning

confidence: 99%

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Sirtuins, brain and cognition: A review of resveratrol effects

et al. 2020

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Sirtuins (SIRTs) are a protein family with high preservation degree among evolutionary scale. SIRTs are histone deacetylases regulatory enzymes of genetic material deeply involved in numerous physiological tasks including metabolism, brain function and aging. Mammals sirtuins comprise seven enzymatic components (SIRT1–SIRT7). The highest studied sirtuin is SIRT1, which plays an essential position in the prevention and evolution of neuro-disorders. Resveratrol (3,5,4-trihydroxystylbene) (RSV) is a polyphenol, which belongs to a family compounds identified as stilbenes, predominantly concentrated in grapes and red wine. RSV is the must studied Sirtuin activator and is used as food supplementary compound. Resveratrol exhibits strong antioxidant activity, reducing free radicals, diminishing quinone-reductase-2 activity and exerting positive regulation of several endogenous enzymes. Resveratrol is also able to inhibit pro-inflammatory factors, reducing the stimulation of the nuclear factor kB (NF-kB) and the release of endogenous cytokines. Resveratrol treatment can modulate multiple signaling pathway effectors related to programmed cell death, cell survival, and synaptic plasticity. In this context, the present review looks over news and the role of Sirtuins activation and resveratrol effects on modulating target genes, cognition and neurodegenerative disorders.

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Section: Sirtuins and Brainmentioning

confidence: 99%

Section: Sirtuins and Brainmentioning

confidence: 99%

Sirtuins, brain and cognition: A review of resveratrol effects

et al. 2020

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“…Numerous studies have demonstrated that SIRT1 plays a central role in the regulation of different biological processes, such as mitochondrial biogenesis, oxidation and inflammation. [10][11][12] SIRT1 is activated in many central nervous system diseases, such as subarachnoid haemorrhage and Parkinson's disease. 13 In addition, it has been reported that it is an important…”

mentioning

confidence: 99%

Sirtuin 1 alleviates neuroinflammation‐induced apoptosis after traumatic brain injury

Guan

Wang

Wu³

et al. 2021

J Cellular Molecular Medi

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The pathophysiological features of traumatic brain injury (TBI) include primary brain injuries, which are difficult to predict, and secondary brain injury. 1,2 Over the course of TBI, neuronal apoptosis occurs through a complex sequence of pathological events that involve several contributing factors, such as excitotoxicity, excitotoxic damage, mitochondrial dysfunction and autophagy. 3 Among these events, inflammation is an important factor that aggravates nerve injury during the process of secondary insult. Although the exact mechanisms responsible for the occurrence of neuronal insult and their final degeneration are equivocal, vast literature suggests an important role of neuroinflammation. 4,5 Cytokine signalling and inflammasome are linked to the 'redox-sensitive' master transcriptional regulator nuclear factor-kappa B (NF-κB). Indeed, activation of NF-κB causes an increase in the interleukin (IL)-1 level, which promotes the cascade of inflammatory factors in microglia (ie TNFα) and astrocytes (ie IL-6). 6,7 Accordingly, restrained activation of NF-κB reduces the neuroinflammatory process, which can prevent neuronal apoptosis. 8 Sirtuin 1 (SIRT1), also known as nicotinamide adenine dinucleotide (NAD)-dependent deacetylase sirtuin-1, contributes to cellular regulation (reaction to stressors and longevity). 9 It is a highly conserved and well-characterized NAD-dependent class III histone deacetylase in mammalian cells. Numerous studies have demonstrated that SIRT1 plays a central role in the regulation of different biological processes, such as mitochondrial biogenesis, oxidation and inflammation. [10][11][12] SIRT1 is activated in many central nervous system diseases, such as subarachnoid haemorrhage and Parkinson's disease. 13 In addition, it has been reported that it is an important

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“…NALFD is a pandemic condition involving also the pediatric population [ 174 , 175 ], and regarded as one of the newest risk factors for neurological diseases [ 176 , 177 ], with the life style and the diet regimen being key factors in the CNS pathology progression [ 178 , 179 , 180 ]. The liver and brain appear to be inter-connected at various levels (so-called liver brain axis): (1) A negative correlation between serum bilirubin concentrations and NAFLD stage has been reported [ 75 , 181 , 182 , 183 , 184 ]; (2) the modulation of HMOX1/CO/iron, in turn acting on sirtuin1 (Sirt1—see Table 2 ), a histone deacetylase controlling the adaptive mechanism to disease and the bilirubin transport in both organs [ 89 , 185 , 186 , 187 ] has been also demonstrated; and (3), the liver and brain may be connected by insulin resistance [ 183 ], a feature of the metabolic syndrome whose CNS consequences have been discussed in Section 2.4 .…”

Section: The Yellow Players (Yp)mentioning

confidence: 99%

The Role of Bilirubin and the Other “Yellow Players” in Neurodegenerative Diseases

et al. 2020

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Bilirubin is a yellow endogenous derivate of the heme catabolism. Since the 1980s, it has been recognized as one of the most potent antioxidants in nature, able to counteract 10,000× higher intracellular concentrations of H2O2. In the recent years, not only bilirubin, but also its precursor biliverdin, and the enzymes involved in their productions (namely heme oxygenase and biliverdin reductase; altogether the “yellow players”—YPs) have been recognized playing a protective role in diseases characterized by a chronic prooxidant status. Based on that, there is an ongoing effort in inducing their activity as a therapeutic option. Nevertheless, the understanding of their specific contributions to pathological conditions of the central nervous system (CNS) and their role in these diseases are limited. In this review, we will focus on the most recent evidence linking the role of the YPs specifically to neurodegenerative and neurological conditions. Both the protective, as well as potentially worsening effects of the YP’s activity will be discussed.

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Overexpression of Sirtuin 1 protein in neurons prevents and reverses experimental diabetic neuropathy

Cited by 57 publications

References 101 publications

Sirtuins, brain and cognition: A review of resveratrol effects

Sirtuins, brain and cognition: A review of resveratrol effects

Sirtuin 1 alleviates neuroinflammation‐induced apoptosis after traumatic brain injury

The Role of Bilirubin and the Other “Yellow Players” in Neurodegenerative Diseases

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