Overexpression of progesterone receptor B increases sensitivity of human colon muscle cells to progesterone

Abstract

Cheng L, Pricolo V, Biancani P, Behar J. Overexpression of progesterone receptor B increases sensitivity of human colon muscle cells to progesterone.

Gender and the Pathogenesis of Gastrointestinal Diseases: The Role of Steroid Sex Hormones in the Development

“…The decreased motilin level might partially be responsible for gastrointestinal hypomotility during pregnancy. These Chinese results were confirmed further by others' findings [23].…”

Estrogen and progesterone receptors in smooth muscle component of deep infiltrating endometriosis

“…Indeed, several investigators have demonstrated the presence of ER and/or PR in the pelvic smooth muscle of such locations from women without endometriosis (20,21). By analogy to uterine leiomyomata, in comparison to adjacent myometrium, the increased expression of ER and/or PR in smooth muscle cells around endometriosis could be the consequence of an increased sensitivity to estrogen and/ or progesterone locally produced by endometriotic foci.…”

Broad tissue expression of membrane progesterone receptor Alpha in normal mice

“…3a, b), providing novel evidence that P4 may have a direct role in controlling gastric acid secretion via mPRa signaling. The roles of mPRa in modulation of intestinal function has not been reported, even though constant expression of PR-b has been reported in the smooth muscle cells of the ileum and colon (Salomaa et al 1989) and over expression of PR-b might be associated with slow transit constipation in female patients (Cheng et al 2008). Bielefeldt et al reported that progestins exert their non-genomic effects on intestinal smooth muscle by decreasing calcium currents, which may contribute to the reduction in muscle contraction observed after P4 administration.…”