Overexpression of Neuregulin-1 Type III Has Impact on Visual Function in Mice

Su, Nan; Zhang, Weiqi; Eter, Nicole; Heiduschka, Peter; Zhang, Mingyue

doi:10.3390/ijms23094489

Cited by 3 publications

(2 citation statements)

References 39 publications

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“…A recent study [ 30 ] brings into discussion, for the first time, the visual disorders determined, in schizophrenia, by the aberrant expression of NRG1. The alterations discovered, through the electroretinography technique, are in the form of early degenerations in the retina.…”

Section: Geneticsmentioning

confidence: 99%

Genetic polymorphism and neuroanatomical changes in schizophrenia

Năstase

Vlaicu²,

Trifu³

2022

Rom J Morphol Embryol

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The article is a review of the latest meta-analyses regarding the genetic spectrum in schizophrenia, discussing the risks given by the disruptedin-schizophrenia 1 (DISC1), catechol-O-methyltransferase (COMT), monoamine oxidases-A/B (MAO-A/B), glutamic acid decarboxylase 67 (GAD67) and neuregulin 1 (NRG1) genes, and dysbindin-1 protein. The DISC1 polymorphism significantly increases the risk of schizophrenia, as well injuries from the prefrontal cortex that affect connectivity. NRG1 is one of the most important proteins involved. Its polymorphism is associated with the reduction of areas in the corpus callosum, right uncinate, inferior lateral fronto-occipital fascicle, right external capsule, fornix, right optic tract, gyrus. NRG1 and the ErbB4 receptor (tyrosine kinase receptor) are closely related to the N-methyl-D-aspartate receptor (NMDAR) (glutamate receptor). COMT is located on chromosome 22 and together with interleukin-10 (IL-10) have an anti-inflammatory and immunosuppressive function that influences the dopaminergic system. MAO gene methylation has been associated with mental disorders. MAO-A is a risk gene in the onset of schizophrenia, more precisely a certain type of single-nucleotide polymorphism (SNP), at the gene level, is associated with schizophrenia. In schizophrenia, we find deficits of the γ-aminobutyric acid (GABA)ergic neurotransmitter, the dysfunctions being found predominantly at the level of the substantia nigra. In schizophrenia, missing an allele at GAD67, caused by a SNP, has been correlated with decreases in parvalbumin (PV), somatostatin receptor (SSR), and GAD ribonucleic acid (RNA). Resulting in the inability to mature PV and SSR neurons, which has been associated with hyperactivity.

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Section: Geneticsmentioning

confidence: 99%

Genetic polymorphism and neuroanatomical changes in schizophrenia

Năstase

Vlaicu²,

Trifu³

2022

Rom J Morphol Embryol

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“…Nrg1 (Neuregulin 1) is one of the widely studied susceptible genes for schizophrenia [1][2][3][4]. Nrg1 spans 1.125 mega-bases comprising over 20 exons, and more than 30 splice isoforms are grouped into six types (I-VI) [1,5].…”

Section: Introductionmentioning

confidence: 99%

A Novel Form of Neuregulin 1 Type III Caused by N-Terminal Processing

Wang,

Zhang,

Wang

et al. 2023

Biomolecules

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Nrg1 (Neuregulin 1) type III, a susceptible gene of schizophrenia, exhibits a critical role in the central nervous system and is essential at each stage of Schwann’s cell development. Nrg1 type III comprises double-pass transmembrane domains, with the N-terminal and C-terminal localizing inside the cells. The N-terminal transmembrane helix partially overlaps with the cysteine-rich domain (CRD). In this study, Nrg1 type III constructs with different tags were transformed into cultured cells to verify whether CRD destroyed the transmembrane helix formation. We took advantage of immunofluorescent and immunoprecipitation assays on whole cells and analyzed the N-terminal distribution. Astonishingly, we found that a novel form of Nrg1 type III, about 10% of Nrg1 type III, omitted the N-terminal transmembrane helix, with the N-terminal positioning outside the membrane. The results indicated that the novel single-pass transmembrane status was a minor form of Nrg1 type III caused by N-terminal processing, while the major form was a double-pass transmembrane status.

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