Overexpression of microRNA-155 predicts poor prognosis in glioma patients

Sun, Jun; Shi, Huachao; Lai, Niansheng; Liao, Keman; Zhang, Shuai; Lu, Xiao‐Jie

doi:10.1007/s12032-014-0911-x

Cited by 43 publications

(25 citation statements)

References 15 publications

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“…MiR-155 was found to have prognostic impact in patients with various types of cancer (17) including lung cancer (18), leukemia (15, 16), breast cancer (33), renal cell carcinoma (34), glioma (35), colorectal cancer (36) and gallbladder carcinoma (37). We additionally assessed the correlation of miR-155 with survival in two independent and already published CLL cohorts (CLL-NEJM (21) and CLL-Clin Cancer Res (22)), in a new ALL cohort (ALL-MDACC), and in four lung cancer datasets (2 new cohorts, NSCLC-Italy and lung adenocarcinoma-MDACC, and the TCGA cohorts for lung adenocarcinoma and squamous cell carcinoma).…”

Section: Resultsmentioning

confidence: 99%

Combining Anti-Mir-155 with Chemotherapy for the Treatment of Lung Cancers

Roosbroeck

Fanini

Setoyama

et al. 2017

Clinical Cancer Research

124

126

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Purpose The oncogenic microRNA miR-155 is upregulated in many human cancers and its expression is increased in more aggressive and therapy resistant tumors, but the molecular mechanisms through which miR-155 increases therapy resistance are not fully understood. The main objectives of this study were to determine the role of miR-155 in resistance to chemotherapy and to evaluate anti-miR-155 treatment to chemosensitize tumors. Experimental Design We performed in vitro studies on cell lines to investigate the role of miR-155 in therapy resistance. To assess the effects of miR-155 inhibition on chemoresistance, we used an in vivo orthotopic lung cancer model of athymic nude mice, which we treated with anti-miR-155 alone or in combination with chemotherapy. To analyze the association of miR-155 expression and the combination of miR-155 and TP53 expression with cancer survival, we studied 956 patients with lung cancer, chronic lymphocytic leukemia and acute lymphoblastic leukemia. Results We demonstrate that miR-155 induces resistance to multiple chemotherapeutic agents in vitro, and that downregulation of miR-155 successfully resensitizes tumors to chemotherapy in vivo. We show that miR-155 and TP53, the most frequently deregulated tumor suppressor, are linked in a negative feedback mechanism, and demonstrate that a combination of high expression of miR-155 and low expression of TP53 is significantly associated with shorter survival in lung cancer. Conclusions Our findings support the existence of a miR-155/TP53 feedback loop, which is involved in resistance to chemotherapy and which can be specifically targeted to overcome drug resistance, still the main cause of cancer-related deaths.

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Section: Resultsmentioning

confidence: 99%

Combining Anti-Mir-155 with Chemotherapy for the Treatment of Lung Cancers

Roosbroeck

Fanini

Setoyama

et al. 2017

Clinical Cancer Research

124

126

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“…Recently, several reports demonstrated that miRNA expression is down‐ or up‐regulated in gliomas compared with normal brain tissues. miR‐221, miR‐21, and miR‐155 were up‐regulated [Quintavalle et al, ; Sun et al, ; Yang et al, ], whereas miR‐128, miR‐181a, and miR‐320a were down‐regulated in glioma specimens [Chen et al, ; Shi et al, ; Guo et al, ]. Let‐7f is a member of the Let‐7 family, which is down‐regulated in several malignancies, including hepatocellular carcinoma, ovarian carcinoma, and head and neck cancer [Vaksman et al, ; Zheng et al, ; Ge et al, ]; however, Let‐7f is up‐regulated and has oncogenic roles in primary breast cancer [Kuehbacher et al, ].…”

Section: Discussionmentioning

confidence: 99%

Let-7f Inhibits Glioma Cell Proliferation, Migration, and Invasion by Targeting Periostin

et al. 2015

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Glioma is one of the most aggressive and malignant tumor types. Despite advances in surgery, imaging, chemotherapy, and radiation, glioma patient prognosis remains poor. Glioma pathogenesis is an urgent problem that must be solved. MicroRNAs (miRNAs) are endogenous small non-coding RNAs that are key post-transcriptional regulators of gene expression. miRNA deregulation commonly occurs in human tumorigenesis. In the present study, the expression levels of Let-7f were down-regulated in both glioma tissues and glioma cells. The enhanced expression of Let-7f suppressed glioma cells proliferation, migration, and invasion via direct targeting perisotin oncogenic activity. Experiments with periostin siRNA or over-expression further suggest that Let-7f may serve as tumor suppressors through perisotin signal. These findings provide insights regarding the role and mechanism of Let-7f in regulating biological behavior of glioma cells via the Let-7f/periostin axis, and Let-7f may serve as a potential therapeutic target in glioma.

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“…Recently, some miRNAs in human gliomas were identified to have potential tumor diagnostic and prognostic values. It has been reported that overexpression of microRNA-155 predicts poor prognosis in glioma patients [13]. miR-27b may promote glioma cell invasion through direct inhibition of Spry2 expression [14].…”

Section: Neurochem Resmentioning

confidence: 99%

MiR-508-5p Inhibits the Progression of Glioma by Targeting Glycoprotein Non-metastatic Melanoma B

Bao

Wang

et al. 2016

Neurochem Res

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Glioma is a severe and highly lethal brain cancer, a malignancy largely stemming from growing in a relatively restrained area of the brain. Hence, the understanding of the molecular regulation of the growth of glioma is critical for improving its treatment. MicroRNA has become a hotspot in research on diseases, especially in the initiation and progression of different types of cancer. However, the molecular function and mechanisms of miR-508-5p in gliomagenesis are still unclear. The aim of this study was to investigate miR-508-5p expression in glioma and determine its effects on proliferation. miR-508-5p expression levels, both in glioma cell lines and in tissue, were significantly lower than in a normal human astrocyte cell line or adjacent tissues. Cell growth was analyzed using a MTT assay and over-expression of miR-508-5p was found to decrease glioma cell growth. Moreover, a bioinformatic analysis was performed, showing that glycoprotein non-metastatic melanoma B (GPNMB) was a direct target for miR-508-5p in glioma cells. Furthermore, in vivo treatment with miR-508-5p reduced GPNMB protein levels in the tumor. Additionally, overexpression of GPNMB without 3'-UTR partially reversed the cell growth arrest induced by miR-508-5p over-expression in glioma cells. In conclusion, these results indicate that increased expression of miR-508-5p might be related to glioma progression, indicating a potential role of miR-508-5p for clinical therapy.

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Overexpression of microRNA-155 predicts poor prognosis in glioma patients

Cited by 43 publications

References 15 publications

Combining Anti-Mir-155 with Chemotherapy for the Treatment of Lung Cancers

Combining Anti-Mir-155 with Chemotherapy for the Treatment of Lung Cancers

Let-7f Inhibits Glioma Cell Proliferation, Migration, and Invasion by Targeting Periostin

MiR-508-5p Inhibits the Progression of Glioma by Targeting Glycoprotein Non-metastatic Melanoma B

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