Overexpression of LAPTM4B-35: A Novel Marker of Poor Prognosis of Prostate Cancer

Abstract

BackgroundLysosome-associated protein transmembrane 4b-35 (LAPTM4B-35) is a member of the mammalian 4-tetratransmembrane spanning protein superfamily, which is overexpressed in several solid malignancies. However, the expression of LAPTM4B-35 and its role in the progression of prostate cancer (PCa) is unknown. The aim of the present study was to investigate the LAPTM4B-35 expression in PCa and its potential relevance to clinicopathological variables and prognosis.MethodsImmunohistochemistry was used to determine the expression of LAPTM4B-35 protein in 180 PCa tissues in comparison with 180 normal benign prostatic hyperplasia (BPH) specimens. The correlation between the expression of the LAPTM4B-35 protein and the clinicopathologic characteristics of patients with PCa was analyzed.ResultsStatistical analysis showed that LAPTM4B-35 expression was significantly elevated in PCa compared with the BPH controls. High LAPTM4B-35 staining was present in 71.11% of all the cases with PCa. The overexpression of LAPTM4B-35 was significantly associated with the lymph node metastasis, seminal vesicle invasion, PCa stage, higher Gleason score, higher preoperative PSA, and biochemical recurrence (BCR). The Kaplan-Meier survival analysis showed that the high expression of LAPTM4B-35 was related to the poor overall survival and BCR-free survival of patients with PCa. Multivariate Cox analysis showed that LAPTM4B-35 was an independent prognostic factor for both overall survival and BCR-free survival of patients with PCa.ConclusionsOverexpression of LAPTM4B-35 may be associated with tumor progression and poor prognosis in PCa and thus may serve as a new molecular marker to predict the prognosis of PCa patients.

miR-188-5p inhibits tumour growth and metastasis in prostate cancer by repressing LAPTM4B expression

“…LAPTM4B located in chromosome 8q22.1 and encoded a 35-kDa protein, LAPTM4B-35, which was a type-III transmembrane protein with four putative transmembrane regions. Mounting evidences show that overexpression of LAPTM4B-35 is associated with a poor prognosis and contributes to cellular transformation, tumorgenesis, and metastatic progression in several human cancers [9-14]. Our data showed that the overexpression of LAPTM4B mRNA and protein in metastatic PCa tissues relative to primary PCa and normal tissue.…”

Association between LAPTM4B gene polymorphism and prostate cancer susceptibility in an Iranian population

“…Zhang et al 23 showed that LAPTM4B-35 is overexpressed in PCa and that high LAPTM4B-35 expression correlated with PCa progression and poor prognosis. They concluded that overexpression of LAPTM4B-35 may serve as a new molecular marker to predict the prognosis of PCa patients.…”

Lysosomal-associated Transmembrane Protein 4B (LAPTM4B) Decreases Transforming Growth Factor β1 (TGF-β1) Production in Human Regulatory T Cells

“…In tumors, it appears to play an oncogenic role. High LAPTM4B levels are associated with poor prognosis in many types of cancers (31)(32)(33)(34)(35)(36)(37)(38)(39)(40)(41), and in vitro and in vivo analyses of cells in which LAPTM4B was overexpressed or silenced indicate that LAPTM4B favors proliferation, migration, invasion, tumorigenesis, and metastasis (42,43). Two mechanisms by which LAPTM4B plays oncogenic roles have recently been identified.…”