Overexpression of KPNA2 correlates with poor prognosis in patients with gastric adenocarcinoma

Abstract

This study aims to investigate the expression and significance of KPNA2 in human gastric adenocarcinoma progression and prognosis. Using immunohistochemistry and real-time reverse transcriptase polymerase chain reaction assay, we identified abnormally elevated expression of KPNA2 in gastric adenocarcinoma tissues compared to paired normal stomach mucosa tissues in 30 patients (p < 0.05). In order to investigate the correlations between KPNA2 and the clinicopathological features of gastric adenocarcinoma, the expression of KPNA2 in 142 patients with gastric adenocarcinoma was detected by immunohistochemistry, and the results showed that overexpression of KPNA2 was associated with the size of tumor (p < 0.001), histological grade (p < 0.001), lymph node involvement (p = 0.001), and tumor node metastasis stage (p < 0.001). Kaplan-Meier survival analysis showed that patients with high KPNA2 expression showed a significantly shorter overall survival time compared with patients with low KPNA2 expression. Multivariate analysis suggested that KPNA2 expression might be an independent prognostic indicator (p < 0.001) for the survival of patients with gastric adenocarcinoma. In conclusion, overexpression of KPNA2 is closely related to progression of gastric adenocarcinoma and might be regarded as an independent predictor of poor prognosis for gastric adenocarcinoma.

Prognostic value of increased KPNA2 expression in some solid tumors: A systematic review and meta-analysis

“…As displayed in the search flow diagram (Figure 1) and updated Prisma checklist (Supplementary Table S1), 24 articles published from 2006-2016, which reported at least one of the mentioned outcomes, were included in this meta-analysis [4, 8, 10–31]. …”

“…First, KPNA2 might serve as a reliable prognostic marker for solid tumors. In this meta-analysis, we included fifteen different cancer types, including breast cancer [14–17], colorectal cancer [11–13], gastric cancer [10, 18, 19], prostate cancer [8], hepatocellular carcinoma [20, 21], epithelial ovarian carcinoma [4, 31], bladder cancer [27], esophageal squamous cell carcinoma [28], endometrial cancer [26], melanoma [30], OMGCT [25], upper tract urothelial carcinoma [29], meningioma [24], astrocytoma [23], head and neck squamous cell cancer [22]. The overall pooled results from these cancer types indicated that elevated KPNA2 expression was associated with patients' poor OS, TTR, RFS and PFS.…”

“…Meanwhile, it has been suggest that elevated KPNA2 could be associated with poor prognosis in a variety of solid tumors, including colorectal cancer [11–13], breast cancer [14–17], gastric cancer [10, 18, 19] and hepatocellular carcinoma [20, 21]. Intriguingly, it was reported that low cytoplasmic and nuclear KPNA2 expression may also predict an adverse outcome in radiotherapy-treated head and neck squamous cell cancer [22].…”

Pleomorphic adenoma gene 1 mediates the role of Karyopherin alpha 2 and has prognostic significance in hepatocellular carcinoma

“…Karyopherin alpha 2 (KPNA2) is one of karyopherin a family, and could form heterodimer with Karyopherin 1 to promote nucleus protein import as an adapter protein [7]. Recent studies have illustrated that KPNA2 might be a critical oncogene and a potential prognostic biomarker in malignant diseases including HCC [8][9][10][11]. Furthermore, KPNA2 knock-down could significantly inhibit HCC proliferation [12].…”

Pleomorphic adenoma gene 1 mediates the role of karyopherin alpha 2 and has prognostic significance in hepatocellular carcinoma

“…Karyopherin alpha 2 (KPNA2) is one of karyopherin a family, and could form heterodimer with Karyopherin 1 to promote nucleus protein import as an adapter protein [7]. Recent studies have illustrated that KPNA2 might be a critical oncogene and a potential prognostic biomarker in malignant diseases including HCC [8]–[11]. Furthermore, KPNA2 knock-down could significantly inhibit HCC proliferation [12].…”