Overexpression of Kif2a promotes the progression and metastasis of squamous cell carcinoma of the oral tongue

Interplay Between Spindle Architecture and Function

“…Given the critical role of the spindle, it is not surprising that many associated factors have been linked to diseases in which chromosome segregation is disrupted (Noatynska et al, 2012). For example, a significant percentage of MAPs that affect spindle assembly or function have altered expression levels at the mRNA or protein level in a variety of cancers (Bieche et al, 2011;Chang et al, 2012;Wang et al, 2010). Chromosome segregation errors in female meiosis also pose a significant problem and lead to the high incidence of human miscarriage and developmental diseases such as Down syndrome (trisomy 21; Hassold and Hunt, 2001).…”

The Krüppel-associated Box Repressor Domain Can Induce Reversible Heterochromatization of a Mouse Locus in Vivo

“…In our mouse model, we find that the Kif2A promoter is active in all tissues examined, consistent with an essential role of its product in mitotic and post-mitotic cellular tubulin dynamics. Of note, because the hereby-described trap mouse line reports on Kif2a promoter activity, it may be of value to generate mouse models of diseases such as squamous cell carcinoma of the tongue, where Kif2A is overexpressed and contributes to cancer progression (40). More generally, the drug-controllable repression of a TetO-containing locus of interest seems particularly well suited for developing preclinical mouse models of human diseases.…”

Oncogenic role of kinesin proteins and targeting kinesin therapy

“…(47) It specifically localizes to centrosomes during mitosis and is necessary for bipolar spindle assembly and normal mitosis completion. (47) Recently, Wang et al (30) reported that KIF2A is upregulated in squamous cell carcinoma of the oral tongue (SCCOT) tissues against paired adjacent tissues and an increased level of KIF2A is also strongly associated with lymph node metastasis and tumor clinical stage. Further results from a transwell chamber assay showed that Tca8113 cells transfected with KIF2A-siRNA had decreased migratory ability compared with nonsense-siRNAtransfected cells, (30) which suggests KIF2A overexpression is associated with the progression, invasion and metastasis of SCCOT and therefore might be used as a predictor for prognosis.…”