Overexpression of hedgehog pathway molecules and FOXM1 in non-small cell lung carcinomas

Gialmanidis, Ioannis P.; Bravou, Vasiliki; Amanetopoulou, Stavroula G.; Varakis, John; Kourea, Helen P.; Papadaki, Helen

doi:10.1016/j.lungcan.2009.01.007

Cited by 97 publications

(84 citation statements)

References 49 publications

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“…Overexpression of SHH, GLI1, GLI2, and SMO has also been reported in tumor tissues of 80 patients with non-small cell lung carcinoma. In this series, elevated expression level of SMO correlated with the presence of nodal disease, implicating its role in metastasis and disease progression [42]. Autocrine activation of the Hh pathway has also been shown in breast cancer, both in cell lines and tumoral tissue studies [43][44][45].…”

Section: Autocrine Stimulationmentioning

confidence: 52%

The Utility of Hedgehog Signaling Pathway Inhibition for Cancer

2012

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Section: Autocrine Stimulationmentioning

confidence: 52%

The Utility of Hedgehog Signaling Pathway Inhibition for Cancer

2012

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“…Thus, FOXM1 may be the target of GLI1 in basal cell carcinomas. In addition, FOXM1 overexpression in non-small cell lung carcinoma has been demonstrated to correlate with PTCH1, SMO and GLI1 expression (48). In present study, the association between FOXM1 and Hh signaling molecules was analyzed, and the results indicated that FOXM1 expression significantly correlated with GLI1 (R=0.405, P<0.001), SHh (R=0.416, P<0.001) and PTCH1 (R=0.281, P=0.012) expression.…”

Section: A B C D E F G Hmentioning

confidence: 57%

Association between FOXM1 and hedgehog signaling pathway in human cervical carcinoma by tissue microarray analysis

et al. 2016

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Abstract. Forkhead box M1 (FOXM1) and hedgehog (Hh) signaling pathway are implicated in the formation and development of human tumors, including cervical cancer. Previous studies have indicated that FOXM1 may be a downstream target gene of the Hh signaling pathway, but their association in cervical cancer is largely unknown. In the present study, the expression of FOXM1 and Hh signaling molecules was evaluated by immunohistochemical analysis in a tissue microarray that contained 70 cervical cancer tissues and 10 normal cervical tissues. In addition, the association of these molecules with clinicopathological parameters, and the association between FOXM1 and various molecules involved in the Hh signaling pathway was investigated. The results indicated that FOXM1 and Hh signaling molecules were overexpressed in cervical cancer tissues. The protein expression levels of FOXM1, glioma-associated oncogene 1 (GLI1) and smoothened (SMO) correlated with the clinical stage of the tumors, while the protein expression levels of Sonic Hh (SHh), patched 1 (PTCH1) and GLI1 correlated with the pathological grade of the tumors. The expression levels of GLI1 were lower in tissues without lymph node metastasis than in tissues with lymph node metastasis. In addition, FOXM1 expression correlated with GLI1, SHh and PTCH1 expression in cancer tissues. These findings confirmed the participation of FOXM1 and the Hh signaling pathway in cervical cancer. Furthermore, the finding that FOXM1 may be a downstream target gene of the Hh signaling pathway in cervical cancer provides a potential novel diagnostic and therapeutic target for cervical cancer.

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“…As a typical cell-cycle-related transcription factor, one of the key roles of FoxM1 in carcinogenesis is to promote tumor proliferation (9). In addition, upregulation of FoxM1 is a frequent event in different tumor types, and FoxM1 deficiency triggers reduced cellular proliferation or even growth arrest (10)(11)(12)(13)(14), which suggests that FoxM1 may play an important role in tumorigenesis and progression. Our results revealed that overexpression of FoxM1 occurred from gastritis to gastric cancer progression and H. pylori-induced FoxM1 expression in vivo and in vitro, so FoxM1 might take part in the early stage of gastric cancer.…”

Section: Discussionmentioning

confidence: 99%

“…Aberrant expression of FoxM1 is involved in several tumor types, including hepatocellular carcinoma, basal cell carcinoma, breast cancer, lung cancer, prostate cancer, glioblastomas, and gastric cancer (10)(11)(12)(13)(14)(15)(16)(17)(18), which implies an oncogene role in carcinogenesis. We previously reported that FoxM1 is upregulated in gastric cancer, and its inhibition leads to cellular senescence (18), but the relevance of H. pylori infection and FoxM1 expression associated with the pathogenesis of gastric cancer remains undefined.…”

Section: Introductionmentioning

confidence: 99%

FoxM1 is Overexpressed in Helicobacter pylori–Induced Gastric Carcinogenesis and Is Negatively Regulated by miR-370

Feng

Wang

Zeng

et al. 2013

Molecular Cancer Research

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Helicobacter pylori (H. pylori) infections are strongly implicated in human gastric mucosa-associated diseases. Forkhead box M1 (FoxM1), a key positive regulator of cell proliferation, is overexpressed in gastric cancer. MicroRNAs are important post-transcriptional regulators of gene expression. In this study, the effects of H. pylori infection on FoxM1 expression and possible mechanisms of carcinogenesis were explored. The expression of FoxM1 was gradually increased in human gastric specimens from inflammation to cancer. FoxM1 upregulation was time-and concentration-dependent in gastric epithelial-derived cell lines infected with H. pylori. CagA, a key virulence factor of H. pylori, was associated with increased FoxM1 expression.

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Overexpression of hedgehog pathway molecules and FOXM1 in non-small cell lung carcinomas

Cited by 97 publications

References 49 publications

The Utility of Hedgehog Signaling Pathway Inhibition for Cancer

The Utility of Hedgehog Signaling Pathway Inhibition for Cancer

Association between FOXM1 and hedgehog signaling pathway in human cervical carcinoma by tissue microarray analysis

FoxM1 is Overexpressed in Helicobacter pylori–Induced Gastric Carcinogenesis and Is Negatively Regulated by miR-370

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