Overexpression of heat shock protein 27 (HSP-27) is associated with bad prognosis in oral squamous cell carcinoma

Ajalyakeen, Haya; Almohareb, Mamdouh; Al-assaf, Maher

doi:10.17219/dmp/119855

Cited by 8 publications

(4 citation statements)

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“…( 17 and Wang et al ( 22 , indicating lower HSP27 marking in relation to the WHO histopathological grading, leading to low protein expression in poorly differentiated SCC and OTSCC cases. Some studies have associated HSP27 expression with increased cell differentiation, suggesting that HSP27 may be a keratinocyte differentiation of 23 , 24 . This may also justify the high expression of this protein in the parabasal and spiny layers of the normal oral mucosa observed herein.…”

Section: Discussionmentioning

confidence: 99%

Immunoexpression of HSP27 does not seem to influence the prognosis of oral tongue squamous cell carcinoma

Torres,

Silva,

Freitas

et al. 2023

Braz. Dent. J.

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New methods of early detection and risk assessment have been studied aiming to predict the prognosis of patients and directing a specialized treatment of the oral tongue squamous cell carcinoma (OTSCC). In this context, several molecular biomarkers have been investigated for this purpose, and, among them, the heat shock protein 27 (HSP27) can be named. The study aimed to analyze whether heat shock protein 27 (HSP27) exerts any influence on OTSCC, correlating its immunoexpression with clinicopathological parameters, and patient survival. The sample comprised 55 OTSCC cases and 20 normal oral mucosa specimens. The malignancy grading systems proposed by the WHO in 2005, Brandwein-Gensler et al., and Almangush et al. were applied in a histomorphological study. HSP27 expressions were evaluated through the Immunoreactivity Score System (IRS). Significant values were considered at p <0.05 for all statistical tests. Higher IRS results were observed for normal oral mucosa specimens when compared to OTSCC cases (p <0.001). No significant associations between HSP27 immunostaining, the analyzed clinicopathological parameters and patient survival were observed. The results of the present study indicate lower HSP27 expression in OTSCC cases compared to normal oral mucosa specimens. Thus, HSP27 expression does not seem to influence patient prognosis.

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Section: Discussionmentioning

confidence: 99%

Immunoexpression of HSP27 does not seem to influence the prognosis of oral tongue squamous cell carcinoma

Torres,

Silva,

Freitas

et al. 2023

Braz. Dent. J.

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“…Heat shock protein expression may be modified according to the degree of tumour tissue differentiation. HSP27 expression seems to be related to higher malignant cell differentiation in endometrial cancers [40] and squamous cancers (uterine cervix, oral epithelium) [18,41], whereas in malignant astrocytomas/glioblastomas, on the contrary, there is lower cell differentiation [42]. This expression can also differ in histopathologically different tumours of the same organ.…”

Section: Discussionmentioning

confidence: 99%

Heat shock protein 27 (HSP27) in patients with ovarian cancer

et al. 2021

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Objectives: Ovarian cancer remains a very common cause of death among women worldwide. The cause is to be found in too late of a diagnostic process and therapeutic difficulties The presence of heat shock proteins in the serum of ovarian cancer patients is still a new area of study. It is necessary to continue studies on the possibilities for using these markers to predict a patient's response to a specific therapy and to monitor treatment progress.

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“…High expression levels of heat shock proteins may be associated with worse prognostic pictures. Thus, having these data available could be crucial for optimizing the individual therapy of individuals with carcinoma [23][24][25][26]. Recent studies have revealed the crucial role of HSPs in maintaining cellular stability and averting programmed cell death (apoptosis).…”

Section: Introductionmentioning

confidence: 99%

The Chaperone System in Tumors of the Vocal Cords: Quantity and Distribution Changes of Hsp10, Hsp27, Hsp60, and Hsp90 during Carcinogenesis

Pitruzzella,

Fucarino,

Modica

et al. 2024

Applied Sciences

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Laryngeal squamous cell carcinoma (LSCC) constitutes a noteworthy subset of head and neck cancers, contributing to about 4.5% of all malignancies. Its clinical behavior and characteristics exhibit variations contingent upon the specific anatomical site affected, with the glottis, supraglottis, and subglottis emerging as the most prevalent locations. Notably, squamous cell carcinoma represents a predominant histological type, accounting for 85% to 95% of all laryngeal cancers. The gender disparity is evident, with a higher incidence among males, exhibiting a ratio of 3.9:1. Moreover, disparities among racial groups are observed, as African American patients tend to manifest the condition at a younger age, coupled with lower overall survival rates compared to their Caucasian, Hispanic, and Asian counterparts. The primary etiological factors implicated in the onset of laryngeal cancer are tobacco and alcohol consumption, with a direct correlation to the intensity and duration of usage. Importantly, the risk diminishes gradually following cessation, necessitating a substantial period of at least 15 years for a return to baseline rates. Given the diverse nature of laryngeal SCC, treatment modalities are tailored based on the specific site and stage of the disease. Therapeutic interventions, such as radiotherapy, transoral laser microsurgery, open horizontal partial laryngectomy, or total laryngectomy, are employed with the overarching goal of preserving organ function. This study delves into the intricate realm of laryngeal SCC, specifically exploring the involvement of heat shock proteins (HSPs) in disease progression. This research meticulously examines the expression levels of Hsp10, Hsp27, Hsp60, and Hsp90 in dysplastic and benign tissue samples extracted from the right vocal cord, utilizing immunohistochemistry analysis. The focal point of the investigation revolves around unraveling the intricate role of these molecular chaperones in tissue differentiation mechanisms and cellular homeostasis, particularly within the inflammatory milieu characteristic of the tumor phenotype. The findings from this study serve as a robust histopathological foundation, paving the way for more in-depth analyses of the underlying mechanisms governing the contribution of the four chaperones to the development of squamous cell carcinoma in the larynx. Additionally, the data gleaned from this research hint at the potential of these four chaperones as valuable biomarkers, not only for diagnostic purposes but also for prognostication and ongoing patient monitoring. As our understanding of the molecular intricacies deepens, the prospect of targeted therapeutic interventions and personalized treatment strategies for laryngeal SCC becomes increasingly promising.

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Overexpression of heat shock protein 27 (HSP-27) is associated with bad prognosis in oral squamous cell carcinoma

Cited by 8 publications

References 0 publications

Immunoexpression of HSP27 does not seem to influence the prognosis of oral tongue squamous cell carcinoma

Immunoexpression of HSP27 does not seem to influence the prognosis of oral tongue squamous cell carcinoma

Heat shock protein 27 (HSP27) in patients with ovarian cancer

The Chaperone System in Tumors of the Vocal Cords: Quantity and Distribution Changes of Hsp10, Hsp27, Hsp60, and Hsp90 during Carcinogenesis

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