Overexpression of Forkhead Box M1 transcription factor and nuclear factor–κB in laryngeal squamous cell carcinoma: a potential indicator for poor prognosis

Jiang, Li; Wang, Peng; Bi, Dingren; Huang, Chuang; Tang, Weixue; Lu, Hong-yi; Chen, Hongyan

doi:10.1016/j.humpath.2010.06.017

Cited by 27 publications

(18 citation statements)

References 25 publications

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“…We previously have demonstrated that FoxM1 was upregulated in LSCC tissues, compared with laryngeal normal tissues (Jiang et al 2011). In current study, we also found that FoxM1 was overexpressed in LSCC cell line (ΔCT (CTFoxM1−CTGAPDH) = 5.77).…”

Section: Overexpression Of Foxm1 In Lscc Cells Was Down-regulated By supporting

confidence: 72%

“…Immunohistochemical staining was performed on 4-μm paraffin tissue sections as described earlier (Jiang et al 2011). Antibodies and dilutions were as follows: rabbit anti-Ki67 polyclonal antibody (Immunoway Biotechnology Company, USA), 1:200; rabbit anti-cleaved caspase-3 polyclonal antibody (Immunoway Biotechnology Company, USA), 1:100.…”

Section: Immunohistochemical Stainingmentioning

confidence: 99%

“…We have previously reported that FoxM1 was overexpressed in LSCC patients and was associated with development of LSCC (Jiang et al 2011). However, the role of the inhibition of FoxM1 in LSCC has not yet been well investigated.…”

Section: Introductionmentioning

confidence: 99%

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Targeting FoxM1 by thiostrepton inhibits growth and induces apoptosis of laryngeal squamous cell carcinoma

Jiang

Wang

et al. 2014

J Cancer Res Clin Oncol

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Section: Overexpression Of Foxm1 In Lscc Cells Was Down-regulated By supporting

confidence: 72%

Section: Immunohistochemical Stainingmentioning

confidence: 99%

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Targeting FoxM1 by thiostrepton inhibits growth and induces apoptosis of laryngeal squamous cell carcinoma

Jiang

Wang

et al. 2014

J Cancer Res Clin Oncol

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“…Convincing evidence has shown that FOXM1 is upregulated in a wide variety of malignant tumors. In accordance, high tumor FOXM1 levels correlated with overall survival in numerous types of human cancers [11,12]. However, little is known about its expression pattern and biological significance in CRC.…”

Section: Discussionmentioning

confidence: 80%

Overexpression of forkhead box protein M1 (FOXM1) plays a critical role in colorectal cancer

Zhang

Shi

et al. 2015

Clin Transl Oncol

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“…Head and neck squamous cell carcinoma, the 11th most common cancer among men worldwide [1], [2], is one of the 6 tumors with a high incidence in China [3]. Laryngeal squamous cell carcinoma (LSCC), which originates from the laryngeal epithelium, has the second highest incidence of all head and neck squamous cell carcinomas, especially in the northern area of China, including Shanxi Province [4].…”

Section: Introductionmentioning

confidence: 99%

Fascin-1, Ezrin and Paxillin Contribute to the Malignant Progression and Are Predictors of Clinical Prognosis in Laryngeal Squamous Cell Carcinoma

et al. 2012

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AimsFascin-1, ezrin and paxillin, cytoskeleton-associated proteins, have been implicated in several human cancers, but their role in laryngeal squamous cell carcinoma (LSCC) is unknown. We investigated the association of their expression and clinicopathologic factors and their prognostic value in LSCC.Materials and MethodsQuantitative RT-PCR and western blot analyses were used to examine mRNA and protein levels in 10 fresh LSCC specimens and 10 corresponding adjacent normal margin (ANM) tissues from patients undergoing surgery in 2012. We used immunohistochemistry to retrospectively study 216 paraffin blocks of LSCC samples from patients (193 men) who had undergone surgery between 2000 and 2006 and had not received special treatment before the diagnosis. Univariate analysis of patient survival involved the Kaplan–Meier method. Multivariate analyses involved the Cox proportional hazards model.ResultsThe relative mRNA and protein levels of fascin-1, ezrin and paxillin were significantly greater in LSCC than ANM tissue (P<0.05). The high expression of fascin-1, ezrin or paxillin was positively correlated with poor tumor differentiation, cervical lymph node metastasis (N+), and advanced clinical stage (III+IV) (P<0.05) but not sex or metastasis. In addition, a high expression of fascin-1 (P = 0.007) or ezrin (P = 0.047) was associated with advanced tumor stage (T3+T4). The expression of fascin-1 was higher in smokers than non-smokers (P = 0.019). A high expression of fascin-1, ezrin or paxillin was associated with poor prognosis.ConclusionsFascin-1, ezrin and paxillin may be prognostic of poor outcome with LSCC after surgery. Our study may lead to establishing new molecular therapeutic targets and/or prognostic biomarkers in LSCC.

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Overexpression of Forkhead Box M1 transcription factor and nuclear factor–κB in laryngeal squamous cell carcinoma: a potential indicator for poor prognosis

Cited by 27 publications

References 25 publications

Targeting FoxM1 by thiostrepton inhibits growth and induces apoptosis of laryngeal squamous cell carcinoma

Targeting FoxM1 by thiostrepton inhibits growth and induces apoptosis of laryngeal squamous cell carcinoma

Overexpression of forkhead box protein M1 (FOXM1) plays a critical role in colorectal cancer

Fascin-1, Ezrin and Paxillin Contribute to the Malignant Progression and Are Predictors of Clinical Prognosis in Laryngeal Squamous Cell Carcinoma

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