Overexpression of Cpg15 Alleviates the Oxidative Stress in Neuronal Cells Via Regulating Redox Enzymes and Nrf2 Antioxidative Pathway

Jiang, Yi; Li, Junjie; Mu, Ya-Wei; Jiang, Huai; Wei, Zixuan; Xiao, Zi-Yao; Zhao, Jingjing; Chen, Xianhua

doi:10.1007/s12640-022-00473-y

Cited by 1 publication

(2 citation statements)

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“…15 Studies have demonstrated that the nuclear factor erythroid 2-related factor 2/heme oxygenase-1 (Nrf2/HO-1) signaling pathway plays a crucial part in oxidative stress. 16 Nrf2 transcriptionally interacts with its downstream HO-1 protein, thereby actuating the antioxidant effect of HO-1. 16 Toll-like receptor 4 (TLR4), a member of the pattern recognition receptor family, acts as a main initiator of inflammatory response.…”

Section: Introductionmentioning

confidence: 99%

“…16 Nrf2 transcriptionally interacts with its downstream HO-1 protein, thereby actuating the antioxidant effect of HO-1. 16 Toll-like receptor 4 (TLR4), a member of the pattern recognition receptor family, acts as a main initiator of inflammatory response. 17 TLR4 can induce the activation of nuclear factor kappa B (NF-κB) which further promotes the inflammatory response, consequently aggravating AR.…”

Section: Introductionmentioning

confidence: 99%

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Daphnetin Mitigates Ovalbumin-Induced Allergic Rhinitis in Mice by Regulating Nrf2/HO-1 and TLR4/NF-kB Signaling

Tian

Jiang

2022

Am J Rhinol�Allergy

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Background Allergic rhinitis (AR) is an inflammatory disorder of nasal mucosa resulting from allergen exposure. Daphnetin (DAP) is a coumarin derivative that has various bioactivities. Nevertheless, its specific function in AR is unclear. Objectives This study is aimed to explore the specific function of DAP in AR. Methods An AR murine model was established by ovalbumin (OVA) induction. Murine sneezing and rubbing behaviors were observed. Hematoxylin-eosin was used for histopathological observation of nasal mucosa. ELISA was utilized for detection of cytokine production in murine serum. Oxidative stress-associated markers were assessed by commercial assay kits. Western blotting was utilized for evaluating protein levels of Toll-like receptor 4 (TLR4) and nuclear factor kappa B (NF-κB) in nasal mucosa. Results DAP alleviated OVA-induced nasal symptoms, inflammatory response and oxidative stress in the AR murine model. DAP activated nuclear factor erythroid 2-related factor 2/heme oxygenase-1 (Nrf2/HO-1) signaling and inactivated TLR4/NF-κB signaling in murine nasal mucosa. Conclusion DAP mitigates OVA-induced AR in mice by activating Nrf2/HO-1 signaling and inactivating TLR4/NF-κB signaling.

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Section: Introductionmentioning

confidence: 99%