Overexpression of c-KIT (CD117) in triple-negative breast cancer

Shams, Tahany M.; Shams, Maher

doi:10.1097/01.xej.0000406601.42226.2d

Cited by 8 publications

(6 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The association between negative C-KIT expression and lymph node metastasis has been reported previously by Tsutsui et al (2006) and Amin et al (2012). In contrast, Shams and Shams (2011) and Kashiwagi et al (2013), in their work on triplenegative breast cancer, found a significant correlation between C-KITexpression and lymph node metastasis. In contrast, Shams and Shams (2011) and Kashiwagi et al (2013), in their work on triplenegative breast cancer, found a significant correlation between C-KITexpression and lymph node metastasis.…”

Section: Discussionmentioning

confidence: 81%

“…However, Chui et al (1996), Simon et al (2004), and Ulivi et al (2004) did not find any significant correlation between C-KIT expression and lymph node metastasis. In addition, a significant correlation between positive C-KIT expression and the tumor grade was proved in some studies (Simon et al, 2004;Tsuda et al, 2005;Diallo et al, 2006;Shams and Shams, 2011), but not proved in others (Nalwoga et al, 2008;Amin et al 2012). In addition, a significant correlation between positive C-KIT expression and the tumor grade was proved in some studies (Simon et al, 2004;Tsuda et al, 2005;Diallo et al, 2006;Shams and Shams, 2011), but not proved in others (Nalwoga et al, 2008;Amin et al 2012).…”

Section: Discussionmentioning

confidence: 95%

See 1 more Smart Citation

Expression of CD117 in normal and neoplastic breast tissue

Elsayed¹,

Shafeek²

2013

Egyptian Journal of Pathology

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 81%

Section: Discussionmentioning

confidence: 95%

Expression of CD117 in normal and neoplastic breast tissue

Elsayed¹,

Shafeek²

2013

Egyptian Journal of Pathology

View full text Add to dashboard Cite

“…[14] C-kit protein expression has been found in malignancies such as myeloid leukemia, small cell lung cancer, seminomas and gastrointestinal stromal tumors. [10] Reduced expression or loss of c-kit expression is seen in high grade breast carcinoma, [1,3,4] advanced ovarian cancers, [15] and melanomas. [7] In breast, kit protein is expressed in normal breast epithelium, non-neoplastic diseases and in 1-13% of cancers.…”

Section: Discussionmentioning

confidence: 99%

“…[1][2][3] As C-kit appears to play a central role in cellular transformation and differentiation, aberrant activation of c-kit leads to development and progression of several human malignancies. [4][5][6] Increased c-kit expression has been found in various malignant tumors such as myeloid leukemias, small cell lung carcinomas and gastrointestinal stromal tumors. On the contrary, reduced expression or complete loss of expression in seen in melanomas.…”

Section: Introductionmentioning

confidence: 99%

CD 117 Immunoexpression in Invasive Breast Carcinoma: Association with various prognostic parameters

Raikar

Kumar

Doreswamy

2018

APALM

View full text Add to dashboard Cite

Background: CD 117 (Cluster Differentiation 117), encoded by the proto-oncogene C-Kit is a transmembrane tyrosine kinase growth factor receptor which inhibits apoptosis and potentiates cell proliferation. In normal breast epithelium, c-kit is highly expressed; however, its expression is low or completely lost in primary invasive breast carcinoma, suggesting its role in breast carcinogenesis. Objective: To evaluate the expression of CD 117 in invasive breast carcinoma and to study its association with various prognostic factors. Materials and Methods: Fifty cases of invasive breast carcinoma of different histological types and grades were evaluated for CD117 immunoexpression and the association of the same was studied with respect to various prognostic factors, ER/PR receptor status and Her2/ neu status. Results: A statistically significant association was seen between negative expression of CD 117 with increased age (p=0.04), higher tumor grade (p=0.02), positive hormone receptor status (ER; p=0.001, PR; 0.005), negative Her2/neu (p=0.006) and tumors having a microvascular density of more than 19 per high power field (p-0.01). Conclusion: CD 117 immunoexpression, either negative or positive in invasive breast carcinoma has to be reported on a routine basis as a negative expression projects the prognosis of breast carcinoma patients and a positive expression will identify patients for a potential therapeutic intervention.

show abstract

“…In addition, CD117 has been expressed in various normal cells types such as mast cells, germ cells, melanocytes, and breast epithelial cells [10]. CD117 has been studied in different types of tumors such as breast cancer, non-small cell lung cancer, esophageal, hepatocellular carcinoma, respectively [10][11][12][13][14]. Despite there are various studies performed in other cancers, it was found that CD117 plays an inadequate role in the oral cancer.…”

Section: Introductionmentioning

confidence: 99%

Immunohistochemical Expression of C-Kit in Oral Squamous Cell Carcinoma Patients in South Indian Populations

Sathiyamoorthy

Shyamsundar

Shanmugam

et al. 2018

Asian J Pharm Clin Res

View full text Add to dashboard Cite

Objective: The study was designed to evaluate the C-Kit expression and also to assess the relationship with various clinicopathological characteristics in oral squamous cell carcinoma (OSCC) patients.Methods: A total number of 102 formalin-fixed paraffin-embedded retrospective tissue samples were collected, in which (n =84) were histologically confirmed for OSCC, oral epithelial dysplasia (OED) (n=9), and control group (n=10) and studied immunohistochemically. The baseline characters and the correlation between the protein expression and clinicopathological parameters were analyzed. The survival analysis was performed using Kaplan-Meier Survival Method.Results: OSCC exhibited C-Kit protein expression positivity of 6% and OED with 11.11% with no expression of this protein in control patients. Overall survival analysis showed that patients with negative expression had a better survival than patients with positive expression. However, we found that expression pattern of C-kit did not correlate with various clinicopathological characteristics.Conclusion: Vast amount of study has to be still performed to under the mechanism of OSCC in C-KIT Expression to enhance the prognosis of OSCC patients in the near future.

show abstract

Overexpression of c-KIT (CD117) in triple-negative breast cancer

Cited by 8 publications

References 26 publications

Expression of CD117 in normal and neoplastic breast tissue

Expression of CD117 in normal and neoplastic breast tissue

CD 117 Immunoexpression in Invasive Breast Carcinoma: Association with various prognostic parameters

Immunohistochemical Expression of C-Kit in Oral Squamous Cell Carcinoma Patients in South Indian Populations

Contact Info

Product

Resources

About