2011
DOI: 10.1097/01.xej.0000406601.42226.2d
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Overexpression of c-KIT (CD117) in triple-negative breast cancer

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Cited by 8 publications
(6 citation statements)
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“…The association between negative C-KIT expression and lymph node metastasis has been reported previously by Tsutsui et al (2006) and Amin et al (2012). In contrast, Shams and Shams (2011) and Kashiwagi et al (2013), in their work on triplenegative breast cancer, found a significant correlation between C-KITexpression and lymph node metastasis. In contrast, Shams and Shams (2011) and Kashiwagi et al (2013), in their work on triplenegative breast cancer, found a significant correlation between C-KITexpression and lymph node metastasis.…”
Section: Discussionmentioning
confidence: 81%
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“…The association between negative C-KIT expression and lymph node metastasis has been reported previously by Tsutsui et al (2006) and Amin et al (2012). In contrast, Shams and Shams (2011) and Kashiwagi et al (2013), in their work on triplenegative breast cancer, found a significant correlation between C-KITexpression and lymph node metastasis. In contrast, Shams and Shams (2011) and Kashiwagi et al (2013), in their work on triplenegative breast cancer, found a significant correlation between C-KITexpression and lymph node metastasis.…”
Section: Discussionmentioning
confidence: 81%
“…However, Chui et al (1996), Simon et al (2004), and Ulivi et al (2004) did not find any significant correlation between C-KIT expression and lymph node metastasis. In addition, a significant correlation between positive C-KIT expression and the tumor grade was proved in some studies (Simon et al, 2004;Tsuda et al, 2005;Diallo et al, 2006;Shams and Shams, 2011), but not proved in others (Nalwoga et al, 2008;Amin et al 2012). In addition, a significant correlation between positive C-KIT expression and the tumor grade was proved in some studies (Simon et al, 2004;Tsuda et al, 2005;Diallo et al, 2006;Shams and Shams, 2011), but not proved in others (Nalwoga et al, 2008;Amin et al 2012).…”
Section: Discussionmentioning
confidence: 95%
“…[14] C-kit protein expression has been found in malignancies such as myeloid leukemia, small cell lung cancer, seminomas and gastrointestinal stromal tumors. [10] Reduced expression or loss of c-kit expression is seen in high grade breast carcinoma, [1,3,4] advanced ovarian cancers, [15] and melanomas. [7] In breast, kit protein is expressed in normal breast epithelium, non-neoplastic diseases and in 1-13% of cancers.…”
Section: Discussionmentioning
confidence: 99%
“…[1][2][3] As C-kit appears to play a central role in cellular transformation and differentiation, aberrant activation of c-kit leads to development and progression of several human malignancies. [4][5][6] Increased c-kit expression has been found in various malignant tumors such as myeloid leukemias, small cell lung carcinomas and gastrointestinal stromal tumors. On the contrary, reduced expression or complete loss of expression in seen in melanomas.…”
Section: Introductionmentioning
confidence: 99%
“…In addition, CD117 has been expressed in various normal cells types such as mast cells, germ cells, melanocytes, and breast epithelial cells [10]. CD117 has been studied in different types of tumors such as breast cancer, non-small cell lung cancer, esophageal, hepatocellular carcinoma, respectively [10][11][12][13][14]. Despite there are various studies performed in other cancers, it was found that CD117 plays an inadequate role in the oral cancer.…”
Section: Introductionmentioning
confidence: 99%