Overexpression of Arl6ip5 in osteoblast regulates RANKL subcellualr localization

Wu, Yu Wei; Wang, Miaomiao; Peng, Ying; Ding, Yuedi; Deng, Lili; Fu, Qiang

doi:10.1016/j.bbrc.2015.07.119

Cited by 3 publications

(4 citation statements)

References 30 publications

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“…Furthermore, JWA binds to a variety of proteins (Figure 1C). The NH 2 terminus of JWA is important for the binding between JWA and the receptor activator of NF-kB ligand (RANKL), thus inhibiting osteoclastogenesis [39]. The region between 103rd-117th aa of JWA protein is required for homodimer and heterodimer formation with ADP-ribosylation factor-like 6 interacting protein 1 (ARL6IP1) [40].…”

Section: The Structure and Functions Of Jwamentioning

confidence: 99%

“…This suggests that JWA regulates self-protein stability mainly through protein phosphorylation and ubiquitination of its intracellular signaling molecules [32,37,45]. JWA binds to multiple proteins and participates in the regulation of signaling networks [22,35,[38][39][40][41]46,48,49]. (D) Potential modification sites of JWA from the Phosphosite tool (http://www.phosphosite.org (accessed on 15 August 2022)) [50].…”

Section: The Structure and Functions Of Jwamentioning

confidence: 99%

“…(C) Binding protein of JWA. JWA binds to multiple proteins and participates in the regulation of signaling networks [22,35,[38][39][40][41]46,48,49]. (D) Potential modification sites of JWA from the Phosphosite tool (http://www.phosphosite.org (accessed on 15 August 2022)) [50].…”

Section: The Structure and Functions Of Jwamentioning

confidence: 99%

“…When environmental physicochemical factors (cold and heat stimuli) act on cells, the JWA gene responds rapidly and increases its expression to inhibit oxidative stress and repair DNA damage [12,13,57,58]. In addition, JWA also plays an important role in neuroprotection and osteoblast development [39,42]. Due to its multiple biological functions, JWA is closely associated with a variety of diseases, including neurodegenerative diseases and cancer [14,15,21,59,60].…”

Section: The Structure and Functions Of Jwamentioning

confidence: 99%

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Targeting JWA for Cancer Therapy: Functions, Mechanisms and Drug Discovery

Ding

Liu

Wang

et al. 2022

Cancers

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Tumor heterogeneity limits the precision treatment of targeted drugs. It is important to find new tumor targets. JWA, also known as ADP ribosylation factor-like GTPase 6 interacting protein 5 (ARL6IP5, GenBank: AF070523, 1998), is a microtubule-associated protein and an environmental response gene. Substantial evidence shows that JWA is low expressed in a variety of malignancies and is correlated with overall survival. As a tumor suppressor, JWA inhibits tumor progression by suppressing multiple oncogenes or activating tumor suppressor genes. Low levels of JWA expression in tumors have been reported to be associated with multiple aspects of cancer progression, including angiogenesis, proliferation, apoptosis, metastasis, and chemotherapy resistance. In this review, we will discuss the structure and biological functions of JWA in tumors, examine the potential therapeutic strategies for targeting JWA and explore the directions for future investigation.

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Section: The Structure and Functions Of Jwamentioning

confidence: 99%