Overexpression of ADAMTS-2 in tumor cells and stroma is predictive of poor clinical prognosis in gastric cancer

Jiang, Chun-Yi; Zhou, Yi; Huang, Yiyang; Wang, Yan; Wang, Wei; Kuai, Xiaoling

doi:10.1016/j.humpath.2018.08.030

Cited by 28 publications

(23 citation statements)

References 28 publications

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“…Multivariate analysis further confirmed that lymph node metastasis, tumor stage, and histological grade were independent prognostic factors of poor OSCC prognosis ( Table 3). These results are consistent with those of previous studies and suggest that the ADAMTS family may play a vital role in the development and progression of cancer [52,[56][57][58][59][60]. In HCC, ADAMTS14 expression has been associated with more aggressive cancers and poorer clinical outcomes, which are rs12774070 variants in the TSR domain near the glycosylation site, which may affect the TSR domain and alter cell surface association and sequential processing mechanisms [36].…”

Section: Discussionsupporting

confidence: 91%

“…In human cancers such as breast [56], colon [57], cervical [58], gastric [52], lung cancers [59], leukemia [60], and esophageal squamous cell carcinoma (ESCC), the expression of ADAMTS has been associated with poor prognosis [61]. In the current study, our results show that OSCC patients who presented negative cytoplasmic expression of ADAMTS14 proteins had overall survival times which were notably shorter than those of patients who presented positive cytoplasmic expression of ADAMTS14 ( Figure 2).…”

Section: Discussionmentioning

confidence: 48%

“…ADAMTS3 and ADAMTS14 are involved in the processing of type II procollagen N-propeptidase [51] and type I procollagen N-propeptidase [24], respectively. In gastric cancer, overexpression of ADAMTS2 is associated with poor clinical prognosis [52]. ADAMTS2 is also a potential marker of dysplasia of craniofacial fibrous [53].…”

Section: Discussionmentioning

confidence: 99%

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Decreased Cytoplasmic Expression of ADAMTS14 Is Correlated with Reduced Survival Rates in Oral Squamous Cell Carcinoma Patients

Lin

et al. 2020

Diagnostics

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A disintegrin and metalloproteinase with thrombospondin motif 14 (ADAMTS14) is a member of the zinc-dependent protease family that is implicated in the occurrence and progression of tumors. Oral cancer (OC) is a common cancer worldwide, but it is particularly prevalent in Taiwan. However, whether the expression of ADAMTS14 is correlated with the carcinogenesis and progression of oral squamous cell carcinoma (OSCC) has not yet been investigated. In this study, we used immunohistochemistry (IHC) to examine 250 OSCC specimens in order to identify correlations between the cytoplasmic expression of ADAMTS14 and (1) clinicopathological features of OSCC as well as (2) clinical outcomes of OSCC. Our results indicate that cytoplasmic expression of ADAMTS14 was lower in OSCC tissues than in normal tissues. In analyzing correlations between ADAMTS14 expression and clinicopathological features, we found that negative cytoplasmic expression of ADAMTS14 was significantly associated with higher frequencies of lymph node metastasis and more advanced AJCC stages (III/IV). Kaplan–Meier survival analysis revealed that negative cytoplasmic expression of ADAMTS14 was also associated with significantly worse OSCC survival. Univariate and multivariate analyses confirmed that cytoplasmic expression of ADAMTS14 was associated with lymph node metastasis, tumor stage, and tumor grade and also indicated that cytoplasmic ADAMTS14 expression may be an independent prognostic factor for OSCC. This is the first study to report that the cytoplasmic expression level of ADAMTS14 is associated with OSCC prognosis and tumor progression. Our data indicate that ADAMTS14 can serve as a prognostic marker and a potential therapeutic target for OSCC.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 48%

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Decreased Cytoplasmic Expression of ADAMTS14 Is Correlated with Reduced Survival Rates in Oral Squamous Cell Carcinoma Patients

Lin

et al. 2020

Diagnostics

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“…ADAMTS2 is highly expressed in GC and colon cancer and is closely related to distant metastasis and the prognosis of colon cancer. However, it is an independent prognostic factor for GC [ 23 , 24 ]. We found that the overexpression of ADAMTS2 was associated with unfavorable OS in GC patients, which aligns with the findings of the abovementioned study.…”

Section: Discussionmentioning

confidence: 99%

Prognostic Values for the mRNA Expression of the ADAMTS Family of Genes in Gastric Cancer

Liang

Zhu

Chen

et al. 2020

Journal of Oncology

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The “A Disintegrin and Metalloproteinase with Thrombospondin Motif” (ADAMTS) family of genes is involved in the occurrence and development of different cancers. However, the prognostic value of these genes in gastric cancer (GC) has not been revealed. The present study was thus conducted to determine the prognostic value for the ADAMTS family of genes in GC. First, we evaluated the mRNA expression levels of the ADAMTS family in GC patients using a GEPIA dataset. Thereafter, we determined the prognostic value of these genes by analyzing their mRNA level using the Kaplan–Meier Plotter database. The mRNA expression level of ADAMTS12 was randomly validated by qRT-PCR and meta-analysis while its coexpression genes were derived using Coexpedia. Finally, we performed Gene Ontology (GO) annotation and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses using the OmicShare Tools. Compared to normal tissues, expression of ADAMTS2 and 12 was significantly higher while that of ADAMTS1, 13, and 15 was significantly lower in GC tissues. According to the RNA-seq and gene chip data, the ADAMTS family (6, 7, 12, 15, and 18) of genes was closely related to the prognosis of GC, and their high expression levels were associated with poor prognosis and survival time. In addition, ADAMTS12 was highly expressed in 20 pairs of GC tissues based on RT-PCR (P=0.016) and meta-analysis (SMD: 0.73, 95% CI: 0.32–1.14, P<0.001). GO and KEGG pathway analyses indicated that the ADAMTS12 coexpressed genes were enriched in the pathways of extracellular matrix organization, extracellular matrix structural constituent, extracellular matrix, and protein digestion and absorption. Herein, we discovered the prognostic values and biological roles of the ADAMTS genes in GC.

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“…Compared with the normal tissues, ADAMTS2 expression in GC tumor cells and broblasts was signi cantly increased, and the up-regulation of the ADAMTS2 was associated with poor prognosis of GC patients [40]. Our data demonstrated that the expression of ADAMTS2 increases in GC, p < 0.001, but the high expression did not affect mortality in GC (p > 0.05).…”

Section: Discussionmentioning

confidence: 50%

Identified a Disintegrin and Metalloproteinase with Thrombospondin Motifs 6 Serve as a Novel Gastric Cancer Prognostic Biomarker by Integrating Analysis of Gene Expression Profile

Zhu¹,

Liu²,

Liao³

et al. 2020

Preprint

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Objective: We aimed to explore the prognostic value of a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) genes in gastric cancer (GC).Methods: The RNA-sequencing (RNA-seq) expression data for 351 GC patients and other relevant clinical data was acquired from The Cancer Genome Atlas (TCGA). Survival analysis and a genome-wide gene set enrichment analysis (GSEA) were performed to define the underlying molecular value of the ADAMTS genes in GC development.Results: The Log rank test with both Cox regression and Kaplan–Meier survival analysis showed that ADAMTS6 expression profile correlated with the GC patients’ clinical outcome. Patients with a high expression of ADAMTS6 were associated with poor overall survival (OS). Comprehensive survival analysis of the ADAMTS genes suggests that ADAMTS6 might be an independent predictive factor for the OS in patients with GC. Besides, GSEA demonstrated that ADAMTS6 might be involved in multiple biological processes and pathways, such as the vascular endothelial growth factor A (VEGFA), kirsten rat sarcoma viral oncogene (KRAS), tumor protein P53, c-Jun N-terminal kinase (JNK), cadherin (CDH1) or tumor necrosis factor (TNF) pathways.Conclusions: In summary, our study demonstrated that ADAMTS6 gene could be used as a potential molecular marker for GC prognosis.

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Overexpression of ADAMTS-2 in tumor cells and stroma is predictive of poor clinical prognosis in gastric cancer

Cited by 28 publications

References 28 publications

Decreased Cytoplasmic Expression of ADAMTS14 Is Correlated with Reduced Survival Rates in Oral Squamous Cell Carcinoma Patients

Decreased Cytoplasmic Expression of ADAMTS14 Is Correlated with Reduced Survival Rates in Oral Squamous Cell Carcinoma Patients

Prognostic Values for the mRNA Expression of the ADAMTS Family of Genes in Gastric Cancer

Identified a Disintegrin and Metalloproteinase with Thrombospondin Motifs 6 Serve as a Novel Gastric Cancer Prognostic Biomarker by Integrating Analysis of Gene Expression Profile

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