“…They are generally divided into the group of hyalectanases, including ADAMTS-1, -4, -5, -8, -9, -15, and -20, which mostly target various (hyalectan) proteoglycans, ADAMTS-2, -3 and -14 which process the N-terminal propeptides of collagens, and the remaining group of ADAMTS-6, -7, -10, -12, -13 and -16, which have more specific functions [ 106 , 107 , 108 ]. Accumulating evidence suggests several ADAMTSs are involved in cancer development and progression and can promote tumor development [ 49 , 50 , 51 ], but their roles in proteoglycan proteolysis also have tumor suppressor functions [ 109 ] and their prognostic value was evaluated in the context of different cancers [ 110 , 111 , 112 ]. Since the involvement of different members of the metalloproteinase families has been reported in nearly all known forms of cancer, they are considered one of the most important target protease groups in cancer research.…”