Overcoming the Undesirable Properties of dry-powder Inhalers With Novel Engineered Mannitol Particles

Nokhodchi, Ali; Larhrib, Hassan

doi:10.4155/tde.13.64

Cited by 13 publications

(9 citation statements)

References 16 publications

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“…For example, DPIs are formulated using four types of formulation strategies: Carrier Free, Drug Carrier, Drug Additive, Drug Carrier Additive. Specifically, therapeutic dry powders for inhalation are often composed of fine drug particles and inert coarse carrier particles such as lactose [37] . Sufficient detachment of the drug from its carrier must be guaranteed to improve the delivery efficiency.…”

Section: Drug Formulationmentioning

confidence: 99%

“…For example, mast cell stabilizers such as cromoglicate or nedocromil are used to extend the duration of the device [11] . In the recent decade, non-hygroscopic mannitol exhibits particularly great promise as an attractive carrier in DPI systems to replace lactose [37,39] . Additionally, it is necessary to minimize the adhesion intensity between the drug particle and the inner wall of the inhalers by using surface treatment to reduce inhaler retention and enhance the drug delivery efficacy [40] .…”

Section: Drug Formulationmentioning

confidence: 99%

“…This finding demonstrates that when targeting drugs into deeper lung airways, fiber-like drug carriers may perform more efficiently than spherical ones. A recent study demonstrated that using elongated fine mannitol particles enhance the aerosolization performance of inhalable drugs which may improve the efficiency of drug delivery from the devices [37,85] . It is promising to explore the shape as an important parameter for improved drug delivery performance.…”

Section: Shape Engineering For Novel Drug Carriersmentioning

confidence: 99%

See 2 more Smart Citations

Drug-targeting methodologies with applications: A review

Kleinstreuer

Feng

Childress

2014

WJCC

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Targeted drug delivery to solid tumors is a very active research area, focusing mainly on improved drug formulation and associated best delivery methods/devices. Drug-targeting has the potential to greatly improve drug-delivery efficacy, reduce side effects, and lower the treatment costs. However, the vast majority of drug-targeting studies assume that the drug-particles are already at the target site or at least in its direct vicinity. In this review, drug-delivery methodologies, drug types and drug-delivery devices are discussed with examples in two major application areas: (1) inhaled drug-aerosol delivery into human lung-airways; and (2) intravascular drug-delivery for solid tumor targeting. The major problem addressed is how to deliver efficiently the drug-particles from the entry/infusion point to the target site. So far, most experimental results are based on animal studies. Concerning pulmonary drug delivery, the focus is on the pros and cons of three inhaler types, i.e., pressurized metered dose inhaler, dry powder inhaler and nebulizer, in addition to drug-aerosol formulations. Computational fluid-particle dynamics techniques and the underlying methodology for a smart inhaler system are discussed as well. Concerning intravascular drug-delivery for solid tumor targeting, passive and active targeting are reviewed as well as direct drug-targeting, using optimal delivery of radioactive microspheres to liver tumors as an example. The review concludes with suggestions for future work, considereing both pulmonary drug targeting and direct drug delivery to solid tumors in the vascular system.

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Section: Drug Formulationmentioning

confidence: 99%

Section: Drug Formulationmentioning

confidence: 99%

Section: Shape Engineering For Novel Drug Carriersmentioning

confidence: 99%

See 1 more Smart Citation

Drug-targeting methodologies with applications: A review

Kleinstreuer

Feng

Childress

2014

WJCC

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“…However, its varia tion in physicochemical properties, particle size and surface characteristics renders variability in the dispersion of micron sized drug particles. To address this issue, Nokhodchi and Larhrib explore using engineered mannitol particles with controlled characteristics to control the aerosol performance of the powder [4].…”

Section: Foreword Special Focus: Pulmonary Drug Deliverymentioning

confidence: 99%

Pulmonary Drug Delivery

Kwok

Chan

2013

Ther. Deliv.

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“…α -LM is the most regularly and recurrently used carrier in various commercial DPI formulations. Existing lactose based DPI formulations from different manufacturers have been revealed to differ in the particle size distribution (PSD), amorphous content, water content, and presence of fine and surface characteristic, all of which may cause altering drug aerosolization behavior ( Table 2 ) [ 9 , 10 ]. Thus, most appealing tool to augment the efficiency and effectiveness of dry powder inhaler formulations is utilizing of engineered carrier particles or therapeutic agents.…”

Section: Introductionmentioning

confidence: 99%

Imagine the Superiority of Dry Powder Inhalers from Carrier Engineering

Mehta

2018

Journal of Drug Delivery

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Inhalation therapy has strong history of more than 4000 years and it is well recognized around the globe within every culture. In early days, inhalation therapy was designed for treatment of local disorders such as asthma and other pulmonary diseases. Almost all inhalation products composed a simple formulation of a carrier, usually α-lactose monohydrate orderly mixed with micronized therapeutic agent. Most of these formulations lacked satisfactory pulmonary deposition and dispersion. Thus, various alternative carrier's molecules and powder processing techniques are increasingly investigated to achieve suitable aerodynamic performance. In view of this fact, more suitable and economic alternative carrier's molecules with advanced formulation strategies are discussed in the present review. Furthermore, major advances, challenges, and the future perspective are discussed.

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Overcoming the Undesirable Properties of dry-powder Inhalers With Novel Engineered Mannitol Particles

Cited by 13 publications

References 16 publications

Drug-targeting methodologies with applications: A review

Drug-targeting methodologies with applications: A review

Pulmonary Drug Delivery

Imagine the Superiority of Dry Powder Inhalers from Carrier Engineering

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