Overcoming Antimicrobial Resistance in Bacteria Using Bioactive Magnetic Nanoparticles and Pulsed Electromagnetic Fields

Novickij, Vitalij; Stanevičienė, Ramunė; Vepštaitė-Monstavičė, Iglė; Gruškienė, Rūta; Krivorotova, Tatjana; Sereikaitė, Jolanta; Novickij, Jurij; Servienė, Elena

doi:10.3389/fmicb.2017.02678

Cited by 26 publications

(22 citation statements)

References 64 publications

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“…The IONPs were activated by high pulsed electric and electromagnetic fields to induce additional permeabilization and local magnetic hyperthermia. The results on the assays on the Gram-positive Bacillus subtilis and Gram-negative E. coli showed that the high pulsed magnetic fields increase the antimicrobial efficiency of nisin loaded on the IONPs, similar to electroporation or magnetic hyperthermia methods, resulting in a synergistic treatment [110].…”

Section: Nanomaterials With Unique Features As Potential Weapons Tmentioning

confidence: 99%

Nanomaterials as Promising Alternative in the Infection Treatment

Vallet‐Regí

González

Izquierdo‐Barba

2019

IJMS

143

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Both the prevalence of antibiotic resistance and the increased biofilm-associated infections are boosting the demand for new advanced and more effective treatment for such infections. In this sense, nanotechnology offers a ground-breaking platform for addressing this challenge. This review shows the current progress in the field of antimicrobial inorganic-based nanomaterials and their activity against bacteria and bacterial biofilm. Herein, nanomaterials preventing the bacteria adhesion and nanomaterials treating the infection once formed are presented through a classification based on their functionality. To fight infection, nanoparticles with inherent antibacterial activity and nanoparticles acting as nanovehicles are described, emphasizing the design of the carrier nanosystems with properties targeting the bacteria and the biofilm.

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Section: Nanomaterials With Unique Features As Potential Weapons Tmentioning

confidence: 99%

Nanomaterials as Promising Alternative in the Infection Treatment

Vallet‐Regí

González

Izquierdo‐Barba

2019

IJMS

143

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“…Nevertheless, there are physical factors, especially those not common in nature, that bacteria are vulnerable to. Variations in oxygen concentration and temperature have shown changes in bacterial communities, while the use of pulsed electromagnetic field (PEMF) on NPs decorated with nisin protein presents results similar to electroporation or magnetic hyperthermia [ 21 , 22 ]. Other methods include the use of UV light, high hydrostatic pressure, manosonication, a change in pH, and heat shock [ 23 ].…”

Section: Resistance To Physical Factorsmentioning

confidence: 99%

Resistance and Adaptation of Bacteria to Non-Antibiotic Antibacterial Agents: Physical Stressors, Nanoparticles, and Bacteriophages

et al. 2021

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Antimicrobial resistance is a significant threat to human health worldwide, forcing scientists to explore non-traditional antibacterial agents to support rapid interventions and combat the emergence and spread of drug resistant bacteria. Many new antibiotic-free approaches are being developed while the old ones are being revised, resulting in creating unique solutions that arise at the interface of physics, nanotechnology, and microbiology. Specifically, physical factors (e.g., pressure, temperature, UV light) are increasingly used for industrial sterilization. Nanoparticles (unmodified or in combination with toxic compounds) are also applied to circumvent in vivo drug resistance mechanisms in bacteria. Recently, bacteriophage-based treatments are also gaining momentum due to their high bactericidal activity and specificity. Although the number of novel approaches for tackling the antimicrobial resistance crisis is snowballing, it is still unclear if any proposed solutions would provide a long-term remedy. This review aims to provide a detailed overview of how bacteria acquire resistance against these non-antibiotic factors. We also discuss innate bacterial defense systems and how bacteriophages have evolved to tackle them.

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“…High pulsed electric and electromagnetic fields were applied, and Gram-positive Bacillus subtilis and Gram-negative Escherichia coli were utilized as cell models. This strategy increased the antimicrobial efficiency of nisin similar to electroporation or magnetic hyperthermia methods, and a synergistic treatment was also shown to be possible [116].…”

Section: Antimicrobial Activitymentioning

confidence: 99%

Pharmaceutical Applications of Iron-Oxide Magnetic Nanoparticles

Bruschi

Toledo

2019

Magnetochemistry

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Advances of nanotechnology led to the development of nanoparticulate systems with many advantages due to their unique physicochemical properties. The use of iron-oxide magnetic nanoparticles (IOMNPs) in pharmaceutical areas increased in the last few decades. This article reviews the conceptual information about iron oxides, magnetic nanoparticles, methods of IOMNP synthesis, properties useful for pharmaceutical applications, advantages and disadvantages, strategies for nanoparticle assemblies, and uses in the production of drug delivery, hyperthermia, theranostics, photodynamic therapy, and as an antimicrobial. The encapsulation, coating, or dispersion of IOMNPs with biocompatible material(s) can avoid the aggregation, biodegradation, and alterations from the original state and also enable entrapping the bioactive agent on the particle via adsorption or covalent attachment. IOMNPs show great potential for target drug delivery, improving the therapy as a consequence of a higher drug effect using lower concentrations, thus reducing side effects and toxicity. Different methodologies allow IOMNP synthesis, resulting in different structures, sizes, dispersions, and surface modifications. These advantages support their utilization in pharmaceutical applications, and getting suitable drug release control on the target tissues could be beneficial in several clinical situations, such as infections, inflammations, and cancer. However, more toxicological clinical investigations about IOMNPs are necessary.

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Overcoming Antimicrobial Resistance in Bacteria Using Bioactive Magnetic Nanoparticles and Pulsed Electromagnetic Fields

Cited by 26 publications

References 64 publications

Nanomaterials as Promising Alternative in the Infection Treatment

Nanomaterials as Promising Alternative in the Infection Treatment

Resistance and Adaptation of Bacteria to Non-Antibiotic Antibacterial Agents: Physical Stressors, Nanoparticles, and Bacteriophages

Pharmaceutical Applications of Iron-Oxide Magnetic Nanoparticles

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