Over expression of resistin in adipose tissue of the obese induces insulin resistance

Sadashiv,; Tiwari, Sunita; Paul, Bhola Nath; Kumar, Sandeep; Chandra, Abhijit; Dhananjai, S; Negi, M.P.S.

doi:10.4239/wjd.v3.i7.135

Cited by 33 publications

(22 citation statements)

References 43 publications

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“…For example, we observed a trend for decreased serum resistin concentrations in subjects who received METABO compared to placebo at week 4, but not week 8. High serum resistin concentrations have been found in obese individuals and have been linked to insulin resistance, hence the trend for decreased resistin levels in METABO is an intriguing finding that requires further investigation in a future study [33]. The current study may have been underpowered to detect significant differences in serum adiponectin, given that fat loss occurred in both groups as a result of caloric restriction and a consistent exercise program.…”

Section: Discussionmentioning

confidence: 91%

Eight weeks of supplementation with a multi-ingredient weight loss product enhances body composition, reduces hip and waist girth, and increases energy levels in overweight men and women

Lopez¹,

Ziegenfuss²,

Hofheins³

et al. 2013

Journal of the International Society of Sports Nutrition

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BackgroundNumerous natural products are marketed and sold claiming to decrease body weight and fat, but few undergo finished product-specific research demonstrating their safety and efficacy.ObjectiveTo determine the safety and efficacy of a multi-ingredient supplement containing primarily raspberry ketone, caffeine, capsaicin, garlic, ginger and Citrus aurantium (Prograde Metabolism™ [METABO]) as an adjunct to an eight-week weight loss program.MethodsUsing a randomized, placebo-controlled, double-blind design, 70 obese but otherwise healthy subjects were randomly assigned to METABO or a placebo and underwent 8 weeks of daily supplementation, a calorie restricted diet, and exercise training. Subjects were tested for changes in body composition, serum adipocytokines (adiponectin, resistin, leptin, TNF-α, IL-6) and markers of health including heart rate and blood pressure.ResultsOf the 45 subjects who completed the study, significant differences were observed in: body weight (METABO -2.0% vs. placebo -0.5%, P < 0.01), fat mass (METABO -7.8 vs. placebo -2.8%, P < 0.001), lean mass (METABO +3.4% vs. placebo +0.8%, P < 0.03), waist girth (METABO -2.0% vs. placebo -0.2%, P < 0.0007), hip girth (METABO -1.7% vs. placebo -0.4%, P < 0.003), and energy levels per anchored visual analogue scale (VAS) (METABO +29.3% vs. placebo +5.1%, P < 0.04). During the first 4 weeks, effects/trends for maintaining elevated serum leptin (P < 0.03) and decreased serum resistin (P < 0.08) in the METABO group vs. placebo were also observed. No changes in systemic hemodynamics, clinical blood chemistries, adverse events, or dietary intake were noted between groups.ConclusionsMETABO administration is a safe and effective adjunct to an eight-week diet and exercise weight loss program by augmenting improvements in body composition, waist and hip girth. Adherence to the eight-week weight loss program also led to beneficial changes in body fat in placebo. Ongoing studies to confirm these results and clarify the mechanisms (i.e., biochemical and neuroendocrine mediators) by which METABO exerts the observed salutary effects are being conducted.

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Section: Discussionmentioning

confidence: 91%

Eight weeks of supplementation with a multi-ingredient weight loss product enhances body composition, reduces hip and waist girth, and increases energy levels in overweight men and women

Lopez¹,

Ziegenfuss²,

Hofheins³

et al. 2013

Journal of the International Society of Sports Nutrition

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“…Plasma resistin levels in relation to obesity are not as clear as those for adiponectin. Early studies found that circulating resistin levels are elevated in genetic and DIO in mice (Steppan et al, 2001) and obese humans (Degawa-Yamauchi et al, 2003; Owecki et al, 2011; Sadashiv et al, 2012) whereas other studies found that resistin is downregulated in human obesity (Way et al, 2001; Ye et al, 2013) and rodent obesity (Milan et al, 2002; Maebuchi et al, 2003). As for the relationship between resistin and depression in humans, resistin levels were found to be positively correlated with atypical but not typical depression (Lehto et al, 2010).…”

Section: Metabolic Signals and Emotional Statesmentioning

confidence: 99%

Metabolic disturbances connecting obesity and depression

2013

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Obesity markedly increases the odds of developing depression. Depressed mood not only impairs motivation, quality of life and overall functioning but also increases the risks of obesity complications. Abdominal obesity is a better predictor of depression and anxiety risk than overall adipose mass. A growing amount of research suggests that metabolic abnormalities stemming from central obesity that lead to metabolic disease may also be responsible for the increased incidence of depression in obesity. As reviewed here, a higher mass of dysfunctional adipose tissue is associated with several metabolic disturbances that are either directly or indirectly implicated in the control of emotions and mood. To better comprehend the development of depression in obesity, this review pulls together select findings addressing the link between adiposity, diet and negative emotional states and discusses the evidence that alterations in glucocorticoids, adipose-derived hormones, insulin and inflammatory signaling that are characteristic of central obesity may be involved.

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“…Resistin is upregulated with genetic forms of obesity and downregulated with anti-diabetic drugs (Letra et al, 2014). In postmenopausal women, increased resistin mRNA expression causes insulin resistance and culminates in obesity-related disorders (Sadashiv et al, 2012). Lu et al (2013) attributed neuroprotective effects to resistin due to its efficacy in acting against Aβ deposition.…”

Section: Resistinmentioning

confidence: 99%

Adipose-Derived Molecules–Untouched Horizons in Alzheimer’s Disease Biology

Pichiah

Sankarganesh

Arunachalam

et al. 2020

Front. Aging Neurosci.

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The global incidence of Alzheimer's disease (AD) is on the rise with the increase in obesity and metabolic disease epidemic. Obesity is co-morbid with the increase in mass of adipose tissue, which secretes numerous molecules that are biologically important. Obesity and its associated conditions are perhaps involved in the causative pathway of AD. Immunologically important cytokines such as IL-1β, IL-10, and IL-18, which are released by adipose tissue, are also found to be associated with AD. Besides, the expression of IL-6, IFNγ, and TNF alpha are also associated with AD. Ang-I and Ang-II are found to mediate the progression of AD. Complement factors B, C4b, and H are differentially expressed in AD. Overall, several adipocyte-derived cytokines are found to be dysregulated in AD, and their role in AD remains to be studied. The induction of autophagy is a very promising strategy in the treatment of AD. A variety of adipose-derived molecules have been shown to modulate autophagy. However, very little literature is available on the role of adipose-derived molecules in inducing autophagy in microglial cells of AD. Understanding the role of adipose-derived molecules in the development of AD, especially in the induction of autophagy, would open up new avenues in devising strategies for the treatment of AD.

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Over expression of resistin in adipose tissue of the obese induces insulin resistance

Abstract: Increased SAT resistin mRNA expression probably leads to inducing insulin resistance and thus may be associated with obesity-related disorders in postmenopausal obese women.

Cited by 33 publications

References 43 publications

Eight weeks of supplementation with a multi-ingredient weight loss product enhances body composition, reduces hip and waist girth, and increases energy levels in overweight men and women

Eight weeks of supplementation with a multi-ingredient weight loss product enhances body composition, reduces hip and waist girth, and increases energy levels in overweight men and women

Metabolic disturbances connecting obesity and depression

Adipose-Derived Molecules–Untouched Horizons in Alzheimer’s Disease Biology

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