Ovariectomy is sufficient to accelerate spontaneous skin ageing and to stimulate ultraviolet irradiation-induced photoageing of murine skin

Abstract

These results suggest that ovariectomy alone is sufficient to accelerate skin ageing and to increase UV sensitivity, which results in the further deterioration of the skin and photoageing, and may account for the accelerated skin ageing seen in postmenopausal women.

The Effect of Sunscreen on Skin Elastase Activity Induced by Ultraviolet-A Irradiation

“…1,6,7) Inhibition of the UVB-induced increase in skin elastase activity prevented by the agent maintained the linearity of dermal elastic fibers and inhibited the decrease in skin elasticity, resulting in the inhibition of wrinkle formation. 1,6,7) This finding suggested that application of an elastase inhibitor immediately after UVB exposure would inhibit photoaging of the skin, mainly wrinkles.It has been shown that chronic UVB irradiation of the dorsal skin forms wrinkles in hairless mice 8,9) and that chronic ultraviolet-A (UVA) irradiation forms mainly sags. 8,9) In animal models, chronic UVA irradiation increased skin elastase activity and destroyed the 3-dimensional structure of dermal elastic fibers, decreasing skin elasticity, similarly to UVB irradiation.…”

“…It has been shown that chronic UVB irradiation of the dorsal skin forms wrinkles in hairless mice 8,9) and that chronic ultraviolet-A (UVA) irradiation forms mainly sags. 8,9) In animal models, chronic UVA irradiation increased skin elastase activity and destroyed the 3-dimensional structure of dermal elastic fibers, decreasing skin elasticity, similarly to UVB irradiation.…”

“…8,9) In animal models, chronic UVA irradiation increased skin elastase activity and destroyed the 3-dimensional structure of dermal elastic fibers, decreasing skin elasticity, similarly to UVB irradiation.…”

“…8,9) In animal models, chronic UVA irradiation increased skin elastase activity and destroyed the 3-dimensional structure of dermal elastic fibers, decreasing skin elasticity, similarly to UVB irradiation. 5,[9][10][11] There have been many reports that the application of sunscreens before UV exposure inhibits the photoaging of skin in animal models and in humans.…”

“…8,9) In animal models, chronic UVA irradiation increased skin elastase activity and destroyed the 3-dimensional structure of dermal elastic fibers, decreasing skin elasticity, similarly to UVB irradiation. 5,[9][10][11] There have been many reports that the application of sunscreens before UV exposure inhibits the photoaging of skin in animal models and in humans. 8,[12][13][14][15][16] Based on those findings, application of a sunscreen before UV exposure might be expected to inhibit an increase in skin elastase activity even when UVA is continuously irradiated.…”