Ovarian Yolk Sac Carcinoma in Mice

Majeed, S. K.; Alison, Roger H.; Boorman, Gary A.; Gopinath, C.

doi:10.1177/030098588602300618

Cited by 17 publications

(10 citation statements)

References 2 publications

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“…3B, 3C, 3D), respectively. All of the morphological, histochemical, and immunohistochemical findings were highly comparable to the previously reported cases of yolk sac carcinoma in rodents 2 , 4 , 5 , 10 . PTAH staining was performed to differentiate the possibility of thrombi and produced a negative result.…”

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confidence: 88%

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A case report of a metastatic yolk sac carcinoma in the pulmonary artery of a young female Sprague-Dawley rat

et al. 2016

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Yolk sac carcinoma is an extremely rare tumor in rats and is usually found in the genital system of aged animals. We encountered a yolk sac carcinoma in the pulmonary artery of an 18-week-old female Sprague-Dawley rat. In a repeated dosing toxicity study (once weekly for 4 weeks, intraperitoneal), this rat was unexpectedly found dead on the 55th day after the final administration of the test article. At necropsy, grayish white nodules were found on the lung surface. Histopathologically, tumor emboli were observed in the trunk and branch of the pulmonary artery. Tumor cells with slightly basophilic vacuolated cytoplasm and large vesicular nuclei formed nests or clusters and were embedded in a homogenous eosinophilic and periodic acid-Schiff reaction positive matrix. The tumor cells and matrix were immunoreactive for laminin. The embolic tumor resembled yolk sac carcinoma showing a parietal pattern in rodents. Although the primary site was unknown, the tumor was considered to be a metastatic yolk sac carcinoma.

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confidence: 88%

“…Increased levels of AFP were detected in the sera of rats or humans bearing yolk sac carcinomas. Using immunohistochemistry, it was found that AFP was secreted by the yolk sac carcinoma cells displaying the visceral type 10 , 11 . Thus it was reasonable that AFP was not intensely observed in the present case, which exhibited a parietal pattern.…”

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confidence: 99%

A case report of a metastatic yolk sac carcinoma in the pulmonary artery of a young female Sprague-Dawley rat

et al. 2016

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“…63 Both the neoplastic cells and the matrix stain positive for laminin, 11,54,63 as documented here. Spontaneous yolk sac carcinomas of the reproductive tract are considered rare in both rats and mice, 37,54 and were reported both in breeding animals and in animals who had never been mated. 63 Metastatic spread has been reported in both species, 54,63 although, in our cases, metastases were not detected and the tumors were only locally invasive.…”

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confidence: 99%

Pathology of Aging in NODscidgamma Female Mice

et al. 2017

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In the past decade, NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ (NSG, NOD scid gamma) mice have become a model of choice in several areas of biomedical research; however, comprehensive data on their spontaneous age-related pathology are not currently available in the literature. The prevalence of spontaneous morbidity affecting aged NSG female breeders enrolled in a parasitology study was documented with classification of neoplastic and non-neoplastic (inflammatory, metabolic, degenerative) lesions. Malignant mammary neoplasms were most commonly diagnosed, often accompanied by pulmonary metastases, while a low frequency of lymphoma and histiocytic sarcoma was documented. The major inflammatory conditions were suppurative pleuropneumonia and bronchopneumonia with abscess formation, from which Pasteurella pneumotropica was commonly isolated, followed by otitis media. Both inflammatory and degenerative lesions of the genital tract were identified, along with neoplasms such as endometrial yolk sac carcinomas and granulosa cell tumors. Novel conditions identified included renal tubular degeneration and necrosis associated with 2 concurrent types of intranuclear inclusions, focal or multifocal hyperostosis of the skull, and neuroendocrine tumors of the mesometrium. The majority of degenerative lesions that affected the genital tract, endocrine, and skeletal systems did not represent the actual underlying cause of death but, rather, were considered incidental findings. This study indicates that both inflammatory and neoplastic conditions contribute to morbidity and mortality in experimentally manipulated aged female NSG mice.

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“…3, 2013 CHORIOCARCINOMA, YOLK SAC TUMOR, AND TERATOMA: MOUSE substance (Figures 4 and 5). The hyaline ground substance was reminiscent of Reichert's membrane, the basement membrane separating the visceral and parietal layers of the rodent yolk sac (Majeed et al 1986). These neoplastic cells featured abundant, eosinophilic cytoplasm containing droplets of hyaline proteinaceous material.…”

Section: Resultsmentioning

confidence: 99%

Spontaneous Nonmetastatic Choriocarcinoma, Yolk Sac Carcinoma, Embryonal Carcinoma, and Teratoma in the Testes of a Swiss Albino Mouse

Jamadagni

Lacy³

et al. 2012

Toxicol Pathol

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A 12-week-old Swiss Albino mouse was presented with unilateral (left) testicular enlargement of approximately 1.5 cm in diameter and the right testicle mildly reduced in size and weight. Histopathology evaluation revealed three distinct neoplasms in the left testicle: choriocarcinoma, yolk sac carcinoma, and embryonal carcinoma. Teratoma was diagnosed in the right testicle. The histomorphological and immunohistochemical characteristics of the tumor are presented here. To the best of the authors' knowledge, this is the first report of spontaneous nonmetastasizing choriocarcinoma, yolk sac carcinoma, embryonal carcinoma, and teratoma in testes of a Swiss albino mouse.

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Ovarian Yolk Sac Carcinoma in Mice

Cited by 17 publications

References 2 publications

A case report of a metastatic yolk sac carcinoma in the pulmonary artery of a young female Sprague-Dawley rat

A case report of a metastatic yolk sac carcinoma in the pulmonary artery of a young female Sprague-Dawley rat

Pathology of Aging in NODscidgamma Female Mice

Spontaneous Nonmetastatic Choriocarcinoma, Yolk Sac Carcinoma, Embryonal Carcinoma, and Teratoma in the Testes of a Swiss Albino Mouse

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