Ovarian Type Surface Epithelial Carcinoma of the Testis with Delayed Metastatic Spread

Abstract

Ovarian type surface epithelial carcinomas of the testis and paratestis are rare. The most frequent form is the serous subtype while only a few cases of the mucinous subtype have been reported in the literature. A 67-year-old patient with a mucinous ovarian type surface carcinoma of the testis is presented. The histopathological and immunohistochemical details of this rare lesion are discussed.

Mucinous cystadenocarcinoma of the testis: a case report

“…The lack of testicular parenchyma uninvolved by tumor precludes evaluation of an associated intratubular germ cell neoplasm. However, no teratomatous component was identified in our case, and this is similar to other reported cases of mucinous testicular tumors [2,4,5]. The presence of a ciliated serous component and the psammomatous calcifications suggest an ovarian-type surface epithelial tumor.…”

“…Immunohistochemical stains have been reported to be positive for cytokeratins (CKs), carcinoembryonic antigen, epithelial membrane antigen, S-100, cancer antigen 125, carbohydrate antigen (CA)19-9, and cytokeratin CAM 5.2. Previously reported cases of mucinous cystic tumors of the testis were either positive for both CK 7 and 20 [3] or positive for CK 20 and negative for CK 7 [4][5][6], compatible with an intestinal-type epithelium. The müllerian-type epithelium is usually positive for CK 7, and the primary ovarian mucinous epithelial tumors are typically positive for CK 7 and most often negative for CK 20 [7].…”

“…Another hypothesis is that of development of these tumors by metaplasia of the mesothelium of the tunica vaginalis, which corresponds to the female pelvic mesothelium [1,5]. Most of the mucinous ovarian-type surface epithelial lesions described in the literature [2] are benign or borderline, with only extremely rare reported cases that showed invasion or malignant cytologic features [2,5,9,10,11].…”

Primary testicular mucinous neoplasms: case report and literature review

“…There were 4 cases of carcinoma: 1 patient died 2 months after diagnosis with frankly invasive carcinoma and peritoneal tumour deposits with no other potential primary tumour site identified; 8 1 patient was found to have retroperitoneal lymph node metastases 2 years after diagnosis; 14 and 2 patients were alive without clinically evident recurrence of disease at 1 and 2 years, respectively. 4,13 Of the 15 patients with tumours not considered "overtly-malignant," none were reported to have developed recurrence or metastases, and 1 patient died from unrelated causes 10 years post-surgery.…”

“…Upon reviewing the English literature, we were able to identify 22 cases, not including this present case report. [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16] The first reported case to our knowledge was by Kellert in 1959 who described a mucinous cystadenoma in the paratestis of an 11-year-old boy. 2 It was accompanied by an oviduct-like structure and presumed to have arisen from occult and unidentified ovarian tissue.…”