Ovarian stimulation outcome in infertile women with endometriosis undergoing IVF

Luca, Andrei; Nemescu, Dragoş; Butnaru, Maria; Butnariu, A.; Onofriescu, Mircea

doi:10.17772/gp/60073

Cited by 8 publications

(8 citation statements)

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“…In a third, very small study by Luca et al including patients with known ovarian endometriosis and without previous surgery, no differences in number of MII oocytes retrieved were reported compared to controls. However, sample size calculation was lacking and a lack of statistical power is very likely [70]. Harada and colleagues compared the outcomes of IVF in the ovary following an excision of endometrioma with the contralateral ovary, demonstrating a lower number of oocytes retrieved ( p = 0.009) with comparable fertilization rates.…”

Section: Endometriosis and Clinical Markers Of Oocyte Qualitymentioning

confidence: 99%

Is the oocyte quality affected by endometriosis? A review of the literature

et al. 2017

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Endometriosis is an estrogen-dependent chronic inflammatory condition that affects women in their reproductive period causing infertility and pelvic pain. The disease, especially at the ovarian site has been shown to have a detrimental impact on ovarian physiology. Indeed, sonographic and histologic data tend to support the idea that ovarian follicles of endometriosis patients are decreased in number and more atretic. Moreover, the local intrafollicular environment of patients affected is characterized by alterations of the granulosa cell compartment including reduced P450 aromatase expression and increased intracellular reactive oxygen species generation. However, no comprehensive evaluation of the literature addressing the effect of endometriosis on oocyte quality from both a clinical and a biological perspective has so far been conducted. Based on this systematic review of the literature, oocytes retrieved from women affected by endometriosis are more likely to fail in vitro maturation and to show altered morphology and lower cytoplasmic mitochondrial content compared to women with other causes of infertility. Results from meta-analyses addressing IVF outcomes in women affected would indicate that a reduction in the number of mature oocytes retrieved is associated with endometriosis while a reduction in fertilization rates is more likely to be associated with minimal/mild rather than with moderate/severe disease. However, evidence in this field is still far to be conclusive, especially with regards to the effects of different stages of the disease and to the impact of patients’ previous medical/surgical treatment(s).

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Section: Endometriosis and Clinical Markers Of Oocyte Qualitymentioning

confidence: 99%

Is the oocyte quality affected by endometriosis? A review of the literature

et al. 2017

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“…This benign disease is usually limited to the pelvis and is characterized by peritoneal inflammation, neovascularization, fibrosis, and ovarian cysts [1]. The morbidity for endometriosis ranges from 5-10% and is accompanied by subfertility in women at reproductive age [2,3]. Despite the extensive conducted studies, the aetiology of endometriosis is still unclear.…”

Section: Introductionmentioning

confidence: 99%

The assessment of GWAS — identified polymorphisms associated with infertility risk in Polish women with endometriosis

et al. 2018

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“…In multivariate logistic regression the therapy for endometriosis was found to be a predictive factor for pregnancy after IVF/ICSI. Studies report that endometriosis presence does not affect ovarian response to exogenous gonadotropin stimulation when the ovarian reserve is not significantly impaired [14]. Ovarian reserve could be compromised after previous endometriosis surgical treatment.…”

Section: Discussionmentioning

confidence: 99%