Ovarian sensitivity index is a better measure of ovarian responsiveness to gonadotrophin stimulation than the number of oocytes during in-vitro fertilization treatment

Abstract

Purpose To validate the use of the ovarian sensitivity index (OSI) as a measure of ovarian response during in-vitro fertilization (IVF) treatment. Methods This is a retrospective study carried out in an assisted reproduction unit in a teaching hospital. We analysed data from 2,556 women undergoing the first IVF cycle between 2002 and 2009. OSI was calculated as the number of retrieved oocytes divided by total dose of FSH administered (per 1,000 IU). Its correlation to other parameters of ovarian response was compared to that of the oocyte number. Results The correlation coefficients of OSI with age, AFC, AMH, total dose of gonadotrophin, average daily dose of gonadotrophin and duration of stimulation were significantly higher than that of oocyte number with these respective parameters. OSI demonstrated a higher intraclass correlation coefficient (ICC) than the oocyte number when comparing the two parameters across the first and second stimulated IVF cycles. Conclusions OSI is a better measure of ovarian responsiveness to gonadotrophin stimulation than the oocyte number, and is particularly useful when different subjects are treated with different stimulation regimens which would have confounding effect on the oocyte number.

Effects of previous ovarian drilling on cumulative ongoing pregnancy rates among patients with polycystic ovarian syndrome undergoing in vitro fertilization

“…To take the degree of stimulation into account, one group of authors introduced the ovarian sensitivity index (OSI) to better describe ovarian‐response patterns [23]. In comparison with using the oocyte yield and total gonadotropin dose, the OSI demonstrated a stronger association with AMH levels and live birth rates [23,24]. In the present study, the OSI was lower in patients with a history of LOD than in both the patients with PCOS with no history of LOD and the age‐matched group.…”

“…The conclusions of the present study are also limited by the surgical conditions under which patients received LOD treatment. The effects of LOD on ovarian reserve could be correlated with surgical parameters including the type of cauterization, the dose of energy used, and the number of holes drilled [23–25]. With the wide availability of laparoscopy and improvements in surgical skills, techniques for using LOD in the treatment PCOS continue to develop.…”

Comparing four ovarian reserve markers – associations with ovarian response and live births after assisted reproduction

“…The stimulation‐response variable OSI therefore serves a dynamic surrogate measure of ovarian integrity, and also improves discrimination of poor and excessive response compared with oocyte yield alone . Moreover, OSI as a measure of ovarian response has recently been verified to be superior to oocyte yield alone .…”

Hormonal and Clinical Predictors for Post–egg Retrieval Pain in Women Undergoing Assisted Reproductive Technology Procedures

“…In addition, basal AMH levels and peak E2 levels were found to correlate with peak post-procedural pain, and may be used as predictors for severe pain in women with high pre-procedural hormonal levels. Basal AMH levels have been associated with the total number of follicles on the day of procedure, peak E2 levels and number of retrieved eggs [26], and are used as a predictor for follicular recruitment and influence medication protocols for adjusting gonadotropin stimulation [27,28], but we provide here novel information suggesting it is also associated with the intensity of post-procedural pain. This association of basal AMH level and peak post-egg retrieval pain was not expected.…”