Ovarian reserve parameters and response to controlled ovarian stimulation in infertile patients

Siddiqui, Qurat ul Aman; Anjum, Sagheera; Zahra, Fatima; Yousuf, Sarim Muhammad

doi:10.12669/pjms.35.4.753

Cited by 14 publications

(10 citation statements)

References 21 publications

(23 reference statements)

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“…The present study revealed a gradual decrease of AFC, AFC/age ratio, AMH/age ratio, and ORPI with increase in age of female where decrease in AMH was significant between groups 1, 2, and 3. The decreasing trend of aforementioned four variables is consistent with previous studies [ 4 , 20 , 29 ] and could accurately reflect the diminished status of ovarian reserve of infertile women with ageing. However, the trend of traditional predictors such as FSH, LH, E2, and FSH/LH ratio was not developed in this study.…”

Section: Discussionsupporting

confidence: 90%

“…The reliable markers of ovarian reserve provide an accurate estimation of NOR and GQE in the IVF/ICSI cycles of infertile women. The markers of diminished ovarian reserve and poor ovarian response, including female age, basal serum follicle-stimulating hormone (FSH), estradiol (E2), anti-Müllerian hormone (AMH), inhibin B, antral follicle counts (AFC), and ovarian volume, are used in ovarian stimulation during IVF/ICSI [ 2 – 4 ]. Usually, basal serum FSH level at day 3 was used to predict ovarian reserve, and level >10 IU/liter was considered consistent with poor ovarian response.…”

Section: Introductionmentioning

confidence: 99%

“…Usually, basal serum FSH level at day 3 was used to predict ovarian reserve, and level >10 IU/liter was considered consistent with poor ovarian response. However, compared with AMH, basal serum FSH was not independently associated with ovarian response, NOR, and GQE [ 4 – 7 ].…”

Section: Introductionmentioning

confidence: 99%

“…Recently, AMH has been used to assess ovarian reserve parameters and response to gonadotrophin stimulation, reproductive outcomes of infertile women [ 4 , 7 – 10 ]. AMH is an emerging and one of the strongest markers of NOR during IVF cycles [ 9 , 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

The Predictive Levels of Serum Anti-Müllerian Hormone and the Combined Index of the Number of Retrieved Oocytes and Good-Quality Embryos in Advanced-Age Infertile Women

Sun

Chen

Shi

et al. 2022

International Journal of Endocrinology

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The primary objective of the study was to assess the values of serum anti-Müllerian hormone (AMH) levels and the combined index for the prediction of number of oocytes retrieved (NOR) and number of good-quality embryos (GQE) in infertile women undergoing IVF/ICSI treatment. A group of 521 infertile women aged 21–46 years were recruited as subject in this study. Serum AMH, hormones, and antral follicle count (AFC) were measured. The infertile women were categorized into three groups: 21–34 years (reproductive age), 35–39 years (reproductive age), and 40–46 years (advanced-age infertile). The predictive accuracy of variables was analyzed by the receiver operating characteristic (ROC) curve. AFC, AFC/age ratio, AMH/age ratio, and ovarian response prediction index (ORPI) decreased gradually, while AMH decreased significantly with increase in age. Moreover, NOR and GQE were positively correlated with AFC, AMH, AFC/age ratio, AMH/age ratio, and ORPI ( P < 0.001 ). A statistical significance was observed in predicted oocyte retrieval including AMH, AMH/age ratio, and ORPI between 21–34 years and 35–46 years; especially in the 35–46 years group, these variables reached a “high” grade in the diagnostic accuracy because area under curve (AUC) ranged from 0.982 to 0.988 significantly. No statistical significance was observed for FSH, AMH, AFC, and related combined index predicting GQE. The predictive value of AFC and AFC/age ratio was limited regarding oocyte retrieval; however, AMH, AMH/age ratio, and ORPI concurrently had an excellent value for predicting NOR in reproductive-age women, especially in advanced-age infertile women.

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Section: Discussionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The Predictive Levels of Serum Anti-Müllerian Hormone and the Combined Index of the Number of Retrieved Oocytes and Good-Quality Embryos in Advanced-Age Infertile Women

Sun

Chen

Shi

et al. 2022

International Journal of Endocrinology

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“…AMH is a glycoprotein secreted by granulosa cells of developing ovarian follicles (Siddiqui et al, 2019). It is involved in folliculogenesis and reflects the number of primordial follicles (Seifer & Maclaughlin, 2007;Pellatt et al, 2010;Tobler et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

Correlation between anti-Mu¨llerian hormone, age, and number of oocytes: A retrospective study in a Brazilian in vitro fertilization center

Kozlowski¹,

Carneiro²,

Rosa³

et al. 2021

JBRA Assisted Reproduction

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excluded. The study included women with fertility issues aged 20-50 years submitted to IVF. A total of 733 patients were included. The patients were divided by age into three groups (≤35 years old; 36-39 years old; ≥40 years old).Results: The mean AMH concentration ranged from 2.65 to 1.35 ng/mL and was significantly different between the groups. The mean total number of retrieved oocytes ranged from 9.5 to 5.42 and was significantly different between the groups. The mean number of mature oocytes ranged from 7.14 to 4.58. There was no significant difference in the number of mature oocytes between patients aged 36-39 years and ≥40 years. Negative correlations were observed between patient age and total number of retrieved oocytes (-0.3354) and number of mature oocytes (-0.2839). AMH was negatively correlated with age (-0.3257), although positive correlations with total number of oocytes (0.6702) and number of mature oocytes (0.5770) were observed.Conclusions: This is the largest study performed with Brazilian patients to correlate AMH levels, age, number of oocytes, and number of mature oocytes from controlled ovarian stimulation cycles. Our data showed that as age increases, AMH levels, number of retrieved oocytes, and number of mature oocytes decrease significantly. However, no significant difference in number of mature oocytes was observed when patients aged 36-39 and ≥40 years were compared. In addition, a positive correlation was found between serum AMH levels and total number of retrieved and mature oocytes from stimulated cycles.

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An in silico model using prognostic genetic factors for ovarian response in controlled ovarian stimulation: A systematic review

Eisele

Silva

Bessow

et al. 2021

J Assist Reprod Genet

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Ovarian reserve parameters and response to controlled ovarian stimulation in infertile patients

Cited by 14 publications

References 21 publications

The Predictive Levels of Serum Anti-Müllerian Hormone and the Combined Index of the Number of Retrieved Oocytes and Good-Quality Embryos in Advanced-Age Infertile Women

The Predictive Levels of Serum Anti-Müllerian Hormone and the Combined Index of the Number of Retrieved Oocytes and Good-Quality Embryos in Advanced-Age Infertile Women

Correlation between anti-Mu¨llerian hormone, age, and number of oocytes: A retrospective study in a Brazilian in vitro fertilization center

An in silico model using prognostic genetic factors for ovarian response in controlled ovarian stimulation: A systematic review

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