Ovarian Mucinous Cystadenocarcinoma with Sarcoma‐Like Mural Nodules

Kataoka, Akio; Nishida, Takashi; Ueyama, Takako; Okina, Hideto; Yakushiji, M

doi:10.1111/j.1447-0756.1996.tb00936.x

Cited by 3 publications

(1 citation statement)

References 21 publications

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“…1,4,6,[10][11][12][13]22 They tend to occur in young women (range, 18 to 83 y; mean, 36 y). 1 Grossly they are well delimited, of small (0.6 to 6 cm) size, and hemorrhagic.…”

Section: Discussionmentioning

confidence: 99%

Anaplastic Carcinoma in Mucinous Ovarian Tumors

Provenza

Young

Prat

2008

American Journal of Surgical Pathology

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Several types of mural nodules may develop in the wall of mucinous tumors of the ovary. The histopathologic features and prognosis of foci/nodules of anaplastic carcinoma are not well known. Although they were first thought to carry an invariably unfavorable prognosis, recent data indicate that this does not necessarily apply to stage Ia tumors. Slides from 34 consultation cases of mucinous ovarian tumors with foci/nodules of anaplastic carcinoma were reviewed and classified on the basis of their morphologic features. Cytokeratin stains were done in selected cases. Staging, treatment, and follow-up information were obtained. The foci/nodules of anaplastic carcinoma were classified histologically into 3 groups: (a) rhabdoid (n=12) having a diffuse arrangement of cells with large, bright, eosinophilic cytoplasms, eccentric nuclei, and one or more prominent nucleoli; (b) sarcomatoid (n=10) characterized by a spindle cell proliferation, with atypical and vesicular nuclei often with herringbone pattern; and (c) pleomorphic (n=12) exhibiting overlapping features of the first 2 categories. International Federation of Gynecology and Obstetrics (FIGO) stage was available in 31 cases: 15 were stage Ia, 6 stage Ic, 2 stage II, 7 stage III, and 1 stage IV. Follow-up was obtained in 21 cases. Seven patients died of the disease after a median time of 8 months: 3 stage IC, 1 stage II, 1 stage III, 1 stage IV, and the other was unstaged. Ten patients were alive and clinically free of disease after a median follow-up of 5 years: they were all stage Ia. Three patients (2 stages III and 1 stage IV) were alive with disease at 3 years, 9 months, and 7 months. The other patient (stage Ia) died of an unrelated cause. Thus, only 1 patient with stage Ia disease died, and she died of causes other than ovarian cancer. The presence of foci/nodules of anaplastic carcinoma in unruptured stage I mucinous tumors of the ovary does not necessarily carry an adverse prognosis. These foci/nodules may exhibit rhabdoid, sarcomatoid (spindle cell), or pleomorphic features.

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“…1,4,6,[10][11][12][13]22 They tend to occur in young women (range, 18 to 83 y; mean, 36 y). 1 Grossly they are well delimited, of small (0.6 to 6 cm) size, and hemorrhagic.…”

Section: Discussionmentioning

confidence: 99%

Anaplastic Carcinoma in Mucinous Ovarian Tumors

Provenza

Young

Prat

2008

American Journal of Surgical Pathology

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Malign mural nodules associated with serous ovarian tumor of borderline malignancy: a case report and literature review

Güngör

Altınkaya

Akbay

et al. 2009

Arch Gynecol Obstet

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Sarcoma-Like Mural Nodules in Mucinous Cystic Tumors of the Ovary Revisited

Bagué

Rodrı́guez

Prat

2002

The American Journal of Surgical Pathology

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Ten mucinous cystic ovarian tumors that contained sarcoma-like mural nodules are described. The nodules were studied by conventional and immunohistochemical methods. The sarcoma-like mural nodules occurred predominantly in middle-aged women, were multiple and sharply demarcated from the adjacent mucinous tumor, had small size, and exhibited a heterogeneous cell population. Distinction of these lesions from true sarcomatous nodules and foci of anaplastic carcinoma is important because of the worse prognosis of the two latter tumors compared with the favorable behavior of the sarcoma-like mural nodules. Six of the eight patients with follow-up information were alive and clinically free of recurrence at a mean follow-up interval of 12 years. Two patients died of other causes (thyroid and breast carcinomas). The nature of the nodules is not clear. Sarcoma-like mural nodules probably represent a reactive and self-limited phenomenon within a neoplasia. Their coexpression of vimentin and cytokeratins is consistent with an origin from submesothelial mesenchymal cells, which undergo partial transformation into epithelial cells.

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Ovarian Mucinous Cystadenocarcinoma with Sarcoma‐Like Mural Nodules

Cited by 3 publications

References 21 publications

Anaplastic Carcinoma in Mucinous Ovarian Tumors

Anaplastic Carcinoma in Mucinous Ovarian Tumors

Malign mural nodules associated with serous ovarian tumor of borderline malignancy: a case report and literature review

Sarcoma-Like Mural Nodules in Mucinous Cystic Tumors of the Ovary Revisited

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