Malign mural nodules associated with serous ovarian tumor of borderline malignancy: a case report and literature review

Abstract

The existence of sarcomatous nodules combined with the SLMN necessitates a careful histologic analysis for treatment and the determination of prognosis. However, too few cases of mixed type mural nodules have been published to warrant a conclusion regarding their prognosis.

Asymptomatic Ovarian Mucinous Cystadenoma with a Solid Mural Leiomyoma Case report and brief review

“…More case studies are needed before the pathogenesis of this rare entity can be fully understood. 2 To the best of our knowledge, this is the fourth report of a leiomyomatous mural nodule in a benign mucinous cystadenoma in English medical literature, and the youngest patient reported so far; size-wise this is the second largest tumour. The first case was described by Lifschitz-Mercer et al in 1990, where the presence of a leiomyomatous mural nodule was confirmed by immunohistochemistry.…”

“…They are a heterogeneous group of lesions and can be benign, reactive, or neoplastic in nature. 2 These mural nodules are seen as solid lesions on the wall of the tumour or project into the cyst lumen. Being a part of a large cystic ovarian tumour, they can mimic malignancy both clinically and radiologically.…”

“…The benign and reactive mural nodules have a better prognosis; hence, it is important to differentiate them from the malignant mural nodules. 2,3 Reactive type mural nodules, also called sarcoma-like mural nodules (SLMN), occur in younger females and are usually sharply demarcated small lesions. There are three histological types of SLMNs: epulis-like, the pleomorphic and spindle cell type, and the histiocytic type.…”

“…The existence of sarcomatous nodules combined with the SLMN is another rare entity that has been reported and necessitates a careful histologic analysis for treatment and the determination of prognosis. 2 Classification of these mural nodules is imperative in planning a patient's postoperative therapy and follow-up, and has a general bearing on the overall prognosis of the ovarian tumour it is associated with. 11,12 Our patient did not require any postoperative treatment as the mural nodule was benign.…”

“…Case report and brief review *Mariam Mathew, 1 Hazel Gonsalves, 1 Sinan Al-Azawi, 2 Saparamadu P.A.M 3 case report C ystic tumours of the ovary, whether benign or malignant, may be associated with mural nodules of various types. These mural nodules are composed of an epithelial or stromal component, or a mixture of both.…”