Ovarian epithelial tumors and reproductive factors: a systematic review

Schüler, Susanne; Ponnath, M.; Engel, Jörg B.; Ortmann, O.

doi:10.1007/s00404-013-2784-1

Cited by 79 publications

(68 citation statements)

References 219 publications

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“…Mucinous ovarian carcinoma is suggested to originate from non-ovarian cells and carries different risk factors than other ovarian cancer types [5]. Its risk has been reported not to be affected by oral contraceptives [16,17] but associations with HT use are inconsistent [7,17,18]. Progesterone receptor (PR) expression is lower in mucinous carcinomas than in other ovarian cancer subtypes [19] which may explain its resistance against the protective effect of oral contraceptives.…”

Section: Discussionmentioning

confidence: 97%

Impact of levonorgestrel-releasing intrauterine system use on the cancer risk of the ovary and fallopian tube

et al. 2016

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Background: Levonorgestrel-releasing intrauterine system (LNG-IUS) is used for contraception and heavy menstrual bleeding. A long-term hormone therapy can modify the risk of gynecologic cancers. Little is known about the impact of LNG-IUS use on the risk for invasive and borderline ovarian tumor subtypes or for primary fallopian tube carcinoma. We examined the associations of LNG-IUS use with these tumors. Conclusions: LNG-IUS use associated with decreased risk for both invasive and borderline ovarian tumors. The incidence of primary fallopian tube carcinoma did not significantly differ between LNG-IUS users and the background population.

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Section: Discussionmentioning

confidence: 97%

Impact of levonorgestrel-releasing intrauterine system use on the cancer risk of the ovary and fallopian tube

et al. 2016

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“…The risk of GBC among women is 2-6 times that of men worldwide [46], suggesting the involvement of hormonal factors. During pregnancy, estrogen is highly elevated in serum [7,47]. The gallbladder contains both estrogen and progesterone receptors, and gallbladder tissue is sensitive to these hormones [48].…”

Section: Discussionmentioning

confidence: 99%

Number of parity and the risk of gallbladder cancer: a systematic review and dose–response meta-analysis of observational studies

Guo

Zhou

et al. 2015

Arch Gynecol Obstet

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“…1,[4][5][6][7][8][9][10][11][12][13] For example, a collaborative reanalysis of 45 epidemiologic studies found the risk reduction afforded by OC use was evident for serous, endometrioid and clear cell, but not mucinous, tumors 13 and an analysis in the Ovarian Cancer Cohort Consortium (OCAC) found a positive association between body mass index (BMI) and risk of invasive endometrioid, mucinous and clear cell, but not high grade serous, tumors. 12 However, heterogeneous associations between BMI and EOC histologic subgroups have not been observed in all studies.…”

Section: What's New?mentioning

confidence: 99%

Reproductive and hormone‐related risk factors for epithelial ovarian cancer by histologic pathways, invasiveness and histologic subtypes: Results from the EPIC cohort

Fortner

Ose

Merritt

et al. 2015

Intl Journal of Cancer

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Whether risk factors for epithelial ovarian cancer (EOC) differ by subtype (i.e., dualistic pathway of carcinogenesis, histologic subtype) is not well understood; however, data to date suggest risk factor differences. We examined associations between reproductive and hormone‐related risk factors for EOC by subtype in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Among 334,126 women with data on reproductive and hormone‐related risk factors (follow‐up: 1992–2010), 1,245 incident cases of EOC with known histology and invasiveness were identified. Data on tumor histology, grade, and invasiveness, were available from cancer registries and pathology record review. We observed significant heterogeneity by the dualistic model (i.e., type I [low grade serous or endometrioid, mucinous, clear cell, malignant Brenner] vs. type II [high grade serous or endometrioid]) for full‐term pregnancy (phet = 0.02). Full‐term pregnancy was more strongly inversely associated with type I than type II tumors (ever vs. never: type I: relative risk (RR) 0.47 [95% confidence interval (CI): 0.33–0.69]; type II, RR: 0.81 [0.61–1.06]). We observed no significant differences in risk in analyses by major histologic subtypes of invasive EOC (serous, mucinous, endometrioid, clear cell). None of the investigated factors were associated with borderline tumors. Established protective factors, including duration of oral contraceptive use and full term pregnancy, were consistently inversely associated with risk across histologic subtypes (e.g., ever full‐term pregnancy: serous, RR: 0.73 [0.58–0.92]; mucinous, RR: 0.53 [0.30–0.95]; endometrioid, RR: 0.65 [0.40–1.06]; clear cell, RR: 0.34 [0.18–0.64]; phet = 0.16). These results suggest limited heterogeneity between reproductive and hormone‐related risk factors and EOC subtypes.

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Ovarian epithelial tumors and reproductive factors: a systematic review

Cited by 79 publications

References 219 publications

Impact of levonorgestrel-releasing intrauterine system use on the cancer risk of the ovary and fallopian tube

Impact of levonorgestrel-releasing intrauterine system use on the cancer risk of the ovary and fallopian tube

Number of parity and the risk of gallbladder cancer: a systematic review and dose–response meta-analysis of observational studies

Reproductive and hormone‐related risk factors for epithelial ovarian cancer by histologic pathways, invasiveness and histologic subtypes: Results from the EPIC cohort

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