Number of parity and the risk of gallbladder cancer: a systematic review and dose–response meta-analysis of observational studies

Guo, Ping; Xu, Chang; Zhou, Quan; Zhou, Jianguo; Zhao, Juanjuan; Si, Zhuang-Li; Shen, Cheng; Feng, Chaobo

doi:10.1007/s00404-015-3896-6

Cited by 14 publications

(17 citation statements)

References 47 publications

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“…Risk factors for gallbladder cancer are mainly related to chronic inflammation, infections or gallbladder pathologies such as gallstones, porcelain gallbladder, gallbladder polyps and biliary cysts . Other risk factors include female sex, advanced age, obesity, postmenopausal hormone replacement and parity …”

Section: Introductionmentioning

confidence: 99%

Should we consider gallbladder cancer a new smoking‐related cancer? A comprehensive meta‐analysis focused on dose–response relationships

Lugo

Peveri

Gallus

2019

Intl Journal of Cancer

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The few studies on the association of smoking with gallbladder cancer risk have given conflicting results. Here, we provide the most accurate and up-to-date quantification of the effect of cigarette smoking on gallbladder cancer risk, and investigate for the first time the dose-response relationships. Using an innovative approach for the identification of publications, we conducted a systematic review and meta-analysis of epidemiological studies published until March 2019 on the association of smoking with gallbladder cancer risk. Pooled relative risks (RRs) for smoking were estimated using random-effects models; one-stage randomeffects log-linear models were used for dose-response relationships. Out of 22 eligible articles, 20 (11 case-control and 9 cohort studies) were included in the meta-analysis, for a total of 4,676 gallbladder cancer cases. Compared to never smokers, the pooled RR was 1.33 (95% confidence interval [CI]: 1.17-1.51) for current and 1.07 (95% CI: 0.94-1.23) for former smokers. The risk of gallbladder cancer increased linearly with smoking intensity and duration, the RR being 1.60 (95% CI: 1.21-2.11) for 30 cigarettes/day and 1.25 (95% CI: 1.01-1.56) for 30 years of smoking. There was a nonsignificant linear decrease in gallbladder cancer risk with increasing time since quitting, compared to current smokers. Former smokers reached the risk of those who had never smoked 20 years after quitting. This comprehensive meta-analysis suggests a moderately but significantly higher risk of gallbladder cancer for current but not former smokers. We also provide the first report of a linear increase in gallbladder cancer risk according to smoking intensity and duration.Additional Supporting Information may be found in the online version of this article.

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Section: Introductionmentioning

confidence: 99%

Should we consider gallbladder cancer a new smoking‐related cancer? A comprehensive meta‐analysis focused on dose–response relationships

Lugo

Peveri

Gallus

2019

Intl Journal of Cancer

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“…Furthermore, parity may be more beneficial to women who possess the SE or lack the DERAA sequence in their HLA‐genotype. Similarly, higher parity may be associated with a decreased risk of bladder, endometrial, and pancreatic cancer; however, it should be noted that parity is known to be associated with increased risks of gallbladder cancer and type II diabetes . Therefore, clinicians should weigh carefully the inferred benefits of parity against risks involved for a particular patient before making a formal decision.…”

Section: Discussionmentioning

confidence: 99%

“…Many common risk factors can increase the initiation and promotion of RA, such as genes, age, sex, alcohol, cigarette smoking, and dietary habits . Parity is an important factor for women and is associated with many diseases, such as thyroid cancer, kidney cancer, gallbladder cancer, and type‐II diabetes . Epidemiological studies are increasingly focusing on whether reproductive factors among women may be related to a risk of developing RA.…”

Section: Introductionmentioning

confidence: 99%

Number of parity and the risk of rheumatoid arthritis in women: A dose–response meta‐analysis of observational studies

Ren

Guo

Sun

et al. 2017

J of Obstet and Gynaecol

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Aim: The association between parity and rheumatoid arthritis (RA) risk has been investigated, but results are controversial. Thus, our aim was to systematically analyze the effect of number of parity on the risk of RA in women. Methods: Relevant published studies were identified using PUBMED and EMBASE databases through 1 April 2016. We pooled the relative risks (RR) and 95% confidence intervals (CI) using random-effects models. Results: In all, 12 studies with a total of 2 497 580 participants and 11 521 RA cases were included. A borderline significant inverse association was observed when we compared parity with nulliparity for RA, with summarized RR = 0.90 (95%CI: 0.79-1.02; I 2 = 58.5%, Pheterogeneity = 0.010). In dose-response analysis, we observed a significant nonlinear (Pnonlinearity = 0.000) relation between parity number and the risk of RA. Conclusion:The findings from the current meta-analysis indicate that parity was related to decreased risk of RA. The greatest risk reduction appeared when the parity number reached two. Further studies are warranted to confirm our findings.

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“…Greenland and Orsini were the pioneers of this method [48, 49] [50], we use the method to test a simple quadratic term to the linear model and it was based on the results across categories of tea consumption. Many subsequent studies have described it in detail [51, 52]. …”

Section: Methodsmentioning

confidence: 99%

Tea consumption and the risk of biliary tract cancer: a systematic review and dose-response meta-analysis of observational studies

et al. 2017

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Recent studies have shown that tea consumption is associated with the reduced incidence of some types of cancer, possibly including biliary tract cancer. However, the epidemiological evidences for the association with risk of biliary tract cancer are contradictory. Thus, we performed meta-analysis of published observational studies to assess the association between tea consumption and risk of biliary tract cancer. Relevant studies were identified by searching PubMed, EMBASE, and ISI Web of Science published before October 2016. The Newcastle–Ottawa Scale was used to evaluate the quality of included studies, and publication bias was evaluated using funnel plots, and Begg's and Egger's tests. This meta-analysis includes eight studies comprising 18 independent reports. The incidence of biliary tract cancer reduced about 34% (significantly) for tea intake group in comparison with never intake group (summary odds ratio [OR] = 0.66; 95% confidence interval [CI] = 0.48–0.85). Additionally, an inverse relationship between tea intake and risk of biliary tract cancer was statistically significant in women (OR = 0.65; 95 % CI = 0.47–0.83), but not in men (OR = 0.86; 95% CI = 0.58–1.13). Dose– response analysis indicated that the risk of biliary tract cancer decreased by 4% with each additional cup of tea one day (relative risk [RR] = 0.96, 95% CI = 0.93–0.98, p = 0.001). In summary, tea intake is associated with decreased risk of biliary tract cancer, especially for women.

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Number of parity and the risk of gallbladder cancer: a systematic review and dose–response meta-analysis of observational studies

Abstract: In females, higher parity may be associated with an increased risk of gallbladder cancer. In the future, high-quality cohort studies with larger sample sizes and randomized controlled trials are needed to fully scrutinize this association.

Cited by 14 publications

References 47 publications

Should we consider gallbladder cancer a new smoking‐related cancer? A comprehensive meta‐analysis focused on dose–response relationships

Should we consider gallbladder cancer a new smoking‐related cancer? A comprehensive meta‐analysis focused on dose–response relationships

Number of parity and the risk of rheumatoid arthritis in women: A dose–response meta‐analysis of observational studies

Tea consumption and the risk of biliary tract cancer: a systematic review and dose-response meta-analysis of observational studies

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